CAS: 565-62-8; 3-Methylpent-3-En-2-One

上下游产品

tetrachloromethane acetaldehyde butanone 4-hydroxy-3-methyl-pentan-2-one O-methyl-oxime3-methyl-pent-3-en-2-one O-methyl-oxime 3-Hydroxy-3,4-dimethyl-hex-4-ensaeure-ethylester 4-Methylamino-3-methyl-2-pentanon 3-Hydroxy-2,3,4-trimethyl-hex-4-ensaeure-ethylester

4-羟基-3-甲基戊烷-2-酮 反应生成 3-甲基-3-戊烯-2-酮
参考文献:甲羟戊酸类似物作为胆固醇生物合成的抑制剂.
标题:甲羟戊酸类似物作为胆固醇生物合成的抑制剂.
摘要:合成了一系列20个甲羟戊酸类似物,并测试了它们抑制大鼠肝匀浆中[2-14C]-甲羟戊酸的胆固醇生物合成的能力.从甲羟戊酸中除去5-羟基产生了活性抑制剂3-羟基-3-甲基戊酸.除去3-羟基,在3-位添加芳族基团或插入双键会降低抑制活性.在5位上具有芳香族基团或卤化物的化合物是活性抑制剂.活性最高的抑制剂是5-苯基戊酸,在0.064 Mm时有50%的抑制作用.
DOI:10.1002/jps.2600700910

专利信息

专利号:US-2023212216-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins
发明人：MORRIS ALEXANDER REDFERN; SUTOV GRIGORIJ; BRUNE KARL DIETRICH
权利人:GENIE BIOTECH UK LTD
摘要:Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

专利号:US-11702652-B2
优先权日:2005-12-01
标题:Enzymatic encoding methods for efficient synthesis of large libraries

专利号:AU-2020409711-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins

专利号:EP-4076533-A1
优先权日:2019-12-20
标 题:Synthesis of lactone derivatives and their use in the modification of proteins

专利号:US-6686498-B2
优先权日:2001-03-07
标题:Process for the preparation of Michael-adducts
发明人：JACOBY DENIS
权利人:FIRMENICH & CIE
摘要:The present invention relates to the field of organic synthesis and more specifically to a process for the preparation of Michael-adducts, as defined below, by reacting a beta,beta- or a alpha,beta-disubstituted, or a alpha,beta,beta-trisubstituted, alpha,beta-unsaturated ketone (I) with a beta-ketoester or a beta-diketone (II) in presence of a suitable catalyst of formula M(X)n, according to scheme 1:

专利号:CA-3164962-A1
优先权日:2019-12-20
标题 :Synthesis of lactone derivatives and their use in the modification of proteins