CAS: 672-13-9; 2-Hydroxy-5-Methoxybenzaldehyde

上下游产品

CAS号50-00-0 甲醛 | CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号93-02-7 2,5-二甲氧基苯甲醛 | CAS号80210-54-4 2-(1,3-dithiola... | CAS号64-17-5 乙醇 | CAS号67-66-3 氯仿 | CAS号100-97-0 乌洛托品 | CAS号77287-58-2 2-碘-5-甲氧基苯甲醛 | CAS号591-31-1 3-甲氧基苯甲醛 | CAS号1058225-68-5 2-(Bromomethyl)... | CAS号50551-56-9 5-甲氧基苯并呋喃-2-羧酸乙酯 | CAS号50343-02-7 3-溴-2-羟基-5-甲氧基苯甲醛 | CAS号39900-63-5 2-羟基-5-甲氧基苯腈 | CAS号203987-26-2 (6-FLUORO-1,2,3... | CAS号21587-39-3 1-(5-甲氧基-2-苯并呋喃)乙酮 | CAS号787-07-5 丁二酰丁二酸二乙酯 | CAS号224317-65-1 5-methoxy-2-pro... | CAS号23145-19-9 5-甲氧基苯并呋喃-2-甲醛

2,5-二甲氧基苯甲醛置于aluminium(Iii) Iodide,N,N-二甲基甲酰胺二甲基缩醛体系中,用 乙腈 作为反应溶剂,化学反应 18.0H,以47%的收率获得产物2-羟基-5-甲氧基苯甲醛
参考文献:三碘化铝和n,N-二甲基甲酰胺二甲基乙缩醛对酸不稳定的芳烷基醚的手性辅助选择性裂解.
标题:三碘化铝和n,N-二甲基甲酰胺二甲基乙缩醛对酸不稳定的芳烷基醚的手性辅助选择性裂解.
摘要:N,N-二甲基甲酰胺二甲基乙缩醛(dmf-Dma)利用三碘化铝通过相邻基团的参与选择性裂解醚.包括羧酸盐,烯丙基,叔丁基二甲基甲硅烷基(tbs)和叔丁氧羰基(boc)在内的各种酸不稳定官能团均完好无损.该方法为裂解邻苯二酚单烷基醚和从乙缩醛型保护基(如甲氧基甲基(mom),甲氧基乙氧基甲基(mem)和四氢吡喃基(thp))上化学选择性解吸酚提供了一种有效的方法.
DOI:10.1021/acs.Joc.0C00290

专利信息

专利号:US-4374979-A
优先权日:1981-04-27
标 题:Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
发明人：MITSCHER LESTER A
权利人:UNIV KANSAS ENDOWMENT ASS
摘要:A regiospecific synthesis for anthracyclinones asymmetric is disclosed. The synthesis is based upon a regiospecific bromination of the C-7 position of the alpha -tetralone which after transposing the keto group to the beta -position and reaction with an organo-lithium compound is condensed with a phthalate ester.

专利号:US-5175302-A
优先权日:1987-07-13
标 题 :Nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4837327-A
优先权日:1987-07-13
标 题 :Process for nucleophilic fluoroalkylation of aldehydes
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to alkehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-4999429-A
优先权日:1989-01-09
标 题 :Process for the preparation of α,α,β-1-trifluoro-1-olefinic derivatives
发明人：STAHLY G PATRICK
权利人:ETHYL CORP
摘要:Aryl difluoromethyl sulfone adds to aldehydes under phase transfer conditions to give novel substituted alcohols of the general formula n n RCH(OH)CF.sub.2 SO.sub.2 Ar (I) n n wherein R is an aryl, cycloaliphatic, sec- or tert-aliphatic, or heterocyclic group and Ar is an aryl group. The substituted alcohols of formula I are of particular utility as intermediates in the synthesis of a variety of useful end products. For example, the products of formula I may be utilized in desulfonylation reactions, oxidation reactions and fluorination reactions.

专利号:US-2001024798-A1
优先权日:1998-06-11
标题:Biomimetic combinatorial synthesis
发明人：SHAIR MATTHEW D; LINDSLEY CRAIG W; PELISH HENRY E; SHEEHAN SCOTT M; GOESS BRIAN C; LAYTON MARK E; CHAN LAWRENCE K; CHEN CHUO; WESTWOOD NICHOLAS J
摘要:The present invention provides biomimetic compounds and libraries thereof, as well as methods for their production. In general, the inventive method involves the selection of a desired biological synthetic pathway and mimics that synthetic pathway utilizing modern synthetic tools. The structures formed from this method are preferably generated in fewer than four steps. These scaffold structures can then be functionalized to yield biomimetic compounds and libraries of compounds. In preferred embodiments, biomimetic compounds and libraries are generated from an oxidative phenolic coupling reaction. In other particularly preferred embodiments, the compounds and libraries of compounds are generated from cascade reactions to yield bicyclo [n. 3.1 ] ring systems, medium ring systems, and fused ring systems. In addition to compounds, libraries and methods for their production, the present invention also provides pharmaceutical compositions and methods and kits for determining one or more biological activities of the library members.

专利号:US-6020341-A
优先权日:1994-12-01
标题 :Enediyne quinone imines and methods of preparation and use thereof
发明人：DANISHEFSKY SAMUEL J; SHAIR MATTHEW D; YOON TAEYOUNG; CHOU TING-CHAO; MOSNY KAROLINE K
权利人:SLOAN KETTERING INST CANCER
摘要:A quinone imine enediyne possessing cytotoxic activity towards cancer cells having general structure (I) wherein R 1 , R 2 and R 3 are independently the same or different and are H, Br, Cl, F, NH 2 , CO 2 H, OH, linear or branched alkyl, etc.; wherein R 4 is H, OH or linear or branched alkoxy, linear or branched alkoxycarbonyl, etc.; wherein R 5 is H, Br, Cl, F, Oâ•?, OH or S--SR, or linear or branched alkyl, etc.; wherein R 6 is H, Br, Cl, F, CO 2 H, OH or S--SR', or linear or branched alkyl, etc.; wherein R 7 is H, OH or S--SR', or linear or branched alkyl, linear or branched alkoxycarbonyl, linear or branched alkoxy or linear or branched hydroxyalkyl; and wherein R, R' and R' are independently the same or different and are linear or branched alkyl, linear or branched acyl or linear or branched alkoxyalkyl. Also provided are conjugates of the compound with cleavable peptides, enzymes, carbohydrates and monoclonal antibodies immunoreactive with cancer cells, as well as compositions comprising the analogues and conjugates, and methods of synthesis and treatment of tumos.