专利号:US-10040752-B2 优先权日:2015-08-24 标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof 发明人:MKRTCHYAN GNEL; YAO QINGWEI 权利人:CODY LABORATORIES INC 摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.
专利号:US-8071782-B2 优先权日:2007-10-02 标 题 :Synthesis of 1,3,4-trisubstituted and 1,3,4,5-tetrasubstituted pyrazoles 发明人:DENG XIAOHU; MANI NEELAKANDHA S 权利人:DENG XIAOHU; MANI NEELAKANDHA S; JANSSEN PHARMACEUTICA NV 摘要:This invention concerns the synthesis of highly substituted pyrazoles, which are structural components of pharmacological compounds, through reaction of hydrazones with nitroolefins.
专利号:US-9738647-B2 优先权日:2009-12-24 标题:Methods for the synthesis of polycyclic guanidine compounds 发明人:GRIDNEV ALEXEI 权利人:NOVOMER INC; SAUDI ARAMCO TECH CO 摘要:The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of contacting a described reagent with a triamine compound to provide a polycyclic guanidine compound.
专利号:US-9802953-B2 优先权日:2007-10-03 标 题 :Intermediates and methods for the synthesis of halichondrin B analogs 发明人:CHASE CHARLES E; ENDO ATSUSHI; FANG FRANCIS G; LI JING 权利人:EISAI R&D MAN CO LTD 摘要:Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described.
专利号:US-6455680-B1 优先权日:2000-12-21 标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives 发明人:LUKIN KIRILL A 权利人:ABBOTT LAB 摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.
专利号:EP-0909792-B1 优先权日:1997-10-15 标 题:Storage-stable composition for the synthesis of polyurethanes 发明人:BAUMANN EDWIN; HAEBERLE KARL DR; HORN PETER DR; TREULING ULRICH DR; SCHWAEBISCH HANS 权利人:BASF AG 摘要:Polyurethane synthesis composition using a polymeric emulsifier having a backbone consisting of a copolymer of 4-12C unsaturated dicarboxylic acid or anhydrides and 2-40C olefins, with polyoxyalkylene side chains derived from 2-20C oxiranes. A polyurethane (PU) synthesis composition containing, as emulsifier, a polymer (T) with (at least) a copolymer backbone (TR) derived from 4-12 carbon(C) unsaturated dicarboxylic acid(s) and/or their anhydrides (TR1) and 2-40 C olefin(s) (TR2), and having polyalkylene oxide side chain (TP) derived from 2-20 C oxirane(s) (TP1), together with at least two compounds (a) comprising at least two reactive hydrogen atoms, at least one of which is insoluble. Independent claims are also included for: (a) a process for the production of synthesis composition by contacting the components in presence of a polymer; (b) a PU synthesis composition obtained; (c) a polyurethane obtained by bringing the synthesis composition into contact with a polyisocyanate; and (d) moldings, fibers, coatings, paint, sheets and a foam made from the PU compositions.
摘要:Stephenson, G. R., Science of Synthesis Knowledge Updates, (2014) 1, 215. 摘要:Zaidlewicz, M.; Pakulski, M. M., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 65. 摘要:Steinfeldt, N.; Junge, K., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2017) 2, 36. 摘要:Matsunami, A.; Kayaki, Y.; Ikariya, T., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 47.