CAS: 98737-29-2; (2S,3S)-N-T-Boc-3-Amino-1,2-Epoxy-4-Phenylbutane

上下游产品

methylenedimethyl sulfurane B°C-L-phenylalaninal ((S)-1-benzylallyl)carbamic acid tert-butyl ester tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate butane(2R,3S,1'R)-3-(t-B°C-amino)-2-hydroxy-4-phenyl-1-(1-phenylethyl)aminobutane [(1S,2R)-1-Benzyl-3-((S)-1-tert-butylcarbamoyl-2-phenyl-ethylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester -3(R)-hydroxybutan-4-yl>-L-phenylalanine (2(R)-hydroxy-1(S)-indanyl)amideN-1-phenyl-2(S)-(tert-butoxycarbonyl)amino-3(R)-hydroxybutan-4-yl-L-phenylalanine (2(R)-hydroxy-1(S)-indanyl)amide [(1S,2R)-1-Benzyl-3-((3S,4aS,8aS)-3-tert-butylcarbamoyl-°Ctahydro-isoquinolin-2-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

(3S)-T-Butyldimethylsilyloxy-(2R)-(T-Butyloxycarbonyl)Amino-4-Chloro-1-Phenylthiobutane置于四丁基氟化铵,氢氧化钾体系中,用 四氢呋喃,甲醇 作为反应溶剂,化学反应 2.67H,以75%的收率获得产物1-苄基-2,3-环氧正丙基-氨基甲酸叔丁酯
参考文献:合成手性氮丙啶衍生物作为hiv蛋白酶抑制剂的通用中间体.
标题:合成手性氮丙啶衍生物作为hiv蛋白酶抑制剂的通用中间体.
摘要:[反应:见正文]由d-酒石酸制备手性氮丙啶衍生物1.该化合物可以用作合成羟乙胺类hiv蛋白酶抑制剂(如沙奎那韦,氨普那韦或奈非那韦)的常用中间体.
DOI:10.1021/ol016147S

专利信息

专利号:US-2010184989-A1
优先权日:2007-03-12
标 题 :De Novo Synthesis of Conjugates
发明人：RIGGS-SAUTHIER JENNIFER; DENG BO-LIANG; REN ZHONGXU; ZHANG WEN; GU XUYUAN; DUARTE FRANCO J
权利人:NEKTAR THERAPEUTICS
摘要:The invention provides methods for the preparation of small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer obtained from a water-soluble oligomer composition. Such drugs are produced through modification of a synthetic pathway to attach the oligomer to an intermediate compound followed by completion of the synthetic path.

专利号:US-6573388-B1
优先权日:1999-08-18
标 题:Ethylaziridine derivatives and their preparation methods
发明人：KIM BYUNG MOON; BAE SUNG JIN; SO SOON MOK; KANG JAE SUNG; LEE JOONG HWAN
权利人:SAMCHULLY PHARM CO LTD
摘要:This invention is related to new ethylaziridine derivatives of formula (I) and their preparation. The compounds are useful synthetic intermediates for the synthesis of HIV protease inhibitors and oligopeptide mimetics.

专利号:JP-2010521465-A
优先权日:2007-03-12
标 题 :De novo synthesis of complex

专利号:JP-2013253104-A
优先权日:2007-03-12
标题:De novo synthesis of complex

专利号:US-5550291-A
优先权日:1994-12-06
标 题:Process for key intermediates for HIV protease inhibitors
发明人：BEAULIEU PIERRE L; GUINDON YVAN; WERNIC DOMINIK M
权利人:BIO MEGA BOEHRINGER INGELHEIM
摘要:Disclosed herein is a stereospecific synthesis amenable to the large scale preparation of a hydrochloric acid addition salt of a chlorohydrin of the formula ##STR1## wherein R 1 and R 2 are amino protective groups and R 3 is an amino acid side chain or a protected amino acid side chain. The synthesis involves reacting an aldehyde of the formula ##STR2## wherein R 1 , R 2 and R 3 are as defined hereinbefore with (chloromethyl)lithium at -20° C. or below and contacting the resulting diastereoisomeric mixture of lithium alcoholates with aqueous hydrochloric acid to obtain a separable mixture of the hydrochloric acid addition salts of the chlorohydrin and its corresponding hydroxy diastereoisomer. The hydrochloric acid addition salt of the chlorohydrin is transformed readily into corresponding optionally amino-protected aminoepoxides; for example, 3(S)-(tert-butyloxycarbonylamino)-l,2(S)-epoxy-4-phenyl-butane.