专利号:US-9267213-B1 优先权日:2005-03-25 标题:Electrochemical deblocking solution for electrochemical oligomer synthesis on an electrode array 发明人:MAURER KARL; COOPER JOHN J 权利人:CUSTOMARRAY INC 摘要:There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.
专利号:US-3663578-A 优先权日:1969-10-18 标题 :Catalytic oxidation of alkyl-substituted hydroquinones to the corresponding p-benzoquinones 发明人:KUTEPOW NIKOLAUS VON; MAGIN AUGUST; JOSCHEK HANS-INGO 权利人:BASF AG 摘要:AIR OXIDATION OF ALKYL-SUBSTITUTED HYDROQUINONES IN THE PRESENCE OF HEAVY METAL SALTS AS CATALYSTS IN A LIQUID MIXED PHASE CONSISTING OF AN AQUEOUS PHASE AND AN ORGANIC PHASE. THE AQUEOUS PHASE CONTAINS DISSOLVED CATALYST AND ADDITIVES FOR SETTING UP A PH BELOW 7, AND THE ORGANIC PHASE IS A SELECTIVE SOLVENT FOR THE ALKYL-SUBSTITUTED PBENZOQUINONE FORMED IN THE OXIDATION. THE PROCESS ENABLES 2,3,6-TRIMETHYLHYDROQUINONE, AN IMPORTANT INTERMEDIATE IN THE SYNTHESIS OF VITMIN E, TO BE SEPARATED FROM MIXTURES OF METHYL-SUBSTITUTED HYDROQUINONES.
专利号:US-9725392-B2 优先权日:2015-08-27 标 题:Efficient scalable syntheses of abscisic acid, 8′-acetylene abscisic acid and 8′-cyclopropyl abscisic acid 发明人:JHEENGUT Vishal; NELSON KEN M; ABRAMS SUZANNE R 权利人:NAT RES COUNCIL CANADA 摘要:Methods are provided for synthesis of abscisic acid and 8′ analogues thereof (including an enantiopure 8′-acetylene analogue) including methods wherein the previously reported first step of oxidation of 2,6-dimethylphenol (VI) to 2,6-dimethylbenzoquinone, mono ketal (VII) is replaced by a novel two step process comprising (i) oxidation of 2,6-dimethylphenol (VI) using potassium peroxymonosulfate with a catalytic amount of iodobenzene to produce 2,6-dimethylbenzoquinone (XVI) and (ii) ketalization of 2,6-dimethylbenzoquinone (XVI) using ethylene glycol, trimethylorthoformate with a catalytic amount of p-toluenesulfonic acid to produce 2,6-dimethylbenzoquinone, mono ketal (VII).
专利号:US-9856567-B2 优先权日:2014-06-16 标 题:Synthesis of high-surface-area nanoporous BiVO4 electrodes 发明人:CHOI KYOUNG-SHIN; KIM TAE WOO 权利人:WISCONSIN ALUMNI RES FOUND 摘要:Photoelectrochemical materials and photoelectrodes comprising the materials are provided. The photoelectrochemical materials comprise a porous, high-surface-area BiVO 4 that is composed of particles smaller than the hole diffusion length of BiVO 4 .
专利号:US-11724244-B2 优先权日:2021-02-26 标题:Semiconductor chip devices and methods for polynucleotide synthesis 发明人:MERRIMAN BARRY; DE RIDDER RYAN; HOLDEN MATTHEW T; GEISER TIM 权利人:AVERY DIGITAL DATA INC 摘要:Systems and methods for polynucleotide synthesis utilize electrochemical deprotection and novel redox chemistries compatible with advanced CMOS nodes, for highly reliable and massively scalable parallel construction of polynucleotide segments having a desired sequence or sequences. Via use of these exemplary techniques, low-cost and large-scale polynucleotide synthesis is facilitated, for example for data storage and retrieval applications.
专利号:US-10407676-B2 优先权日:2014-12-09 标题 :High efficiency, small volume nucleic acid synthesis 发明人:POEHMERER THOMAS; KUHN PHILLIP; NOTKA FRANK; ZEIDLER ANDREAS; HEIL KORBINIAN; TREFZER AXEL; FONNUM GEIR; KATZEN FEDERICO; ANDERSSON KRISTIAN 权利人:LIFE TECHNOLOGIES CORP; THERMO FISHER SCIENT GENEART GMBH; LIFE TECH AS 摘要:The disclosure generally relates to compositions and methods for the production of nucleic acid molecules. In some aspects, the invention allows for the microscale generation of nucleic acid molecules, optionally followed by assembly of these nucleic acid molecules into larger molecules. In some aspects, the invention allows for efficient production of nucleic acid molecules (e.g., large nucleic acid molecules such as genomes).
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