CAS: 198560-68-8; (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-3-(3-Fluorophenyl)Propanoic Acid

相似化合物

1820567-10-9 19883-77-3 110117-84-5

上下游产品

3-fluorophenylalanine N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 1-Fluoro-3-iodobenzene Fm°C-3-F-Phe-OMe

间氟碘苯置于碳酸甲丙酯,Lithium Hydroxide Monohydrate,碘苯二乙酸,Silver(I) Acetate,Palladium Diacetate,碳酸氢钠,乙二胺体系中,用 四氢呋喃,1,4-二氧六环,甲醇,二氯甲烷,水 用作溶剂,化学反应 38.0H,反应生成Fmoc-L-3-氟苯丙氨酸
参考文献:使用简单实用的助剂对 α-氨基酸进行配体激活的 β-C-H 芳基化
标题:使用简单实用的助剂对 α-氨基酸进行配体激活的 β-C-H 芳基化
摘要:在过去十年中,人们广泛探索了使用助剂作为导向基团的 Pd 催化的羧酸衍生物的 β-Ch 官能化.与不对称合成中使用最广泛的助剂相比,为 Ch 活化开发的助剂的简单性和实用性仍有待提高.我们之前开发了一种简单的 N-甲氧基酰胺辅助剂来指导 β-Ch 活化,尽管该系统与含有 α-氢原子的羧酸不兼容.在此,我们报道了一种吡啶型配体的开发,该配体克服了 N-甲氧基酰胺助剂的这种限制,从而显着改善了羧酸衍生物,尤其是 α-氨基酸的 β-芳基化.使用这种实用助剂的芳基化应用于非天然氨基酸的克级合成,
Doi:10.1021/ja512690X

专利信息

专利号:WO-2015131100-A1
优先权日:2014-02-28
标题:Ligand-controlled c(sp3)-h arylation and olefination in synthesis of unnatural chiral alpha amino acids
发明人：YU JIN-QUAN
权利人:SCRIPPS RESEARCH INST
摘要:The use of ligands to tune the reactivity and selectivity of transition metal-catalysts for C(-sp3)-H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we report a rare example of catalyst-controlled C(sp3)-H arylation using pyridine and quinoline derivatives: the former promotes exclusive monoarylation, whereas the latter activates the catalyst further to achieve diarylation. Successive application of these ligands enables the sequential diarylation of a methyl group in an alanine derivative with two different aryl iodides, affording a wide range of β-Ar-p-Ar ' -cc-amino acids with excellent levels of diastereoselectivity (d.r. > 20:1). Both configurations of the β-chiral center can be accessed by choosing the order in which the aryl groups are installed. The use of a quinoline derivative as a ligand also enables C(sp3)-H olefination of a protected alanine.

专利号:US-2024215280-A1
优先权日:2022-10-31
标 题:In situ core/shell perovskite nanocrystal material, method of preparation thereof, and light emitting device comprising the same
发明人：LEE TAE-WOO; KIM JOO SUNG
权利人:SEOUL NAT UNIV R&DB FOUNDATION; PEROLED CO LTD
摘要:The present inventive concept relates to an in situ core/shell perovskite nanocrystal film formed by an in situ nanocrystal synthesis process, a method for producing the same, and a light emitting device comprising the same as a light-emitting layer. The in situ core/shell perovskite nanocrystal film formed by the in situ nanocrystal synthesis process according to the present inventive concept exhibits a strong charge confinement effect by nanocrystal formation, and can simultaneously greatly improve the luminescence efficiency and lifetime by maintaining the fast charge transport capability of polycrystalline perovskite.

专利号:US-8338565-B2
优先权日:2008-08-20
标 题 :Macrocyclic compounds for inhibition of tumor necrosis factor alpha
发明人：LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P
权利人:LEE JINBO; BOND JULIAN F; TERRETT NICHOLAS; FAVALORO JR FRANK G; WANG DANIEL; BRIGGS TIMOTHY F; SEIGAL BENJAMIN ADAM; SUN WEI-CHUAN; HALE STEPHEN P; ENSEMBLE THERAPEUTICS CORP
摘要:Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

专利号:US-2024158692-A1
优先权日:2022-10-31
标题 :In-situ core/shell nanoparticle structured metal halide perovskite luminescent material, light emitting device including the same, and manufacturing method thereof
发明人：LEE TAE-WOO; KIM JOO SUNG
权利人:SEOUL NAT UNIV R&DB FOUNDATION; PEROLED CO LTD
摘要:The present inventive concept relates to an in situ core/shell perovskite nanocrystal film formed by an in situ nanocrystal synthesis process, a method for producing the same, and a light emitting device comprising the same as a light-emitting layer. The in situ core/shell perovskite nanocrystal film formed by the in situ nanocrystal synthesis process according to the present inventive concept exhibits a strong charge confinement effect by nanocrystal formation, and can simultaneously greatly improve the luminescence efficiency and lifetime by maintaining the fast charge transport capability of polycrystalline perovskite.