CAS: 19995-38-1; 2-(2-Chloroethyl)Thiophene

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2-chloroethyl tosylate 2-thiophenethanol Benzotrichlorid N-(2-(thiophen-2-yl)ethyl)cyclohexanamine pyridine4-benzyl-6,7-dihydrothieno3,2-cpyridine p-tolyl-6,7-dihydro-thieno[3,2-c]pyridine4-p-tolyl-6,7-dihydro-thieno[3,2-c]pyridine N-(2-Fluoro-phenyl)-2-methoxy-N-[(3S,4R)-3-methyl-1-(2-thiophen-2-yl-ethyl)-piperidin-4-yl]-propionamide

2-噻吩乙醇置于四己基氯化铵,三苯基膦,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 二氯甲烷 用作溶剂,以70%的收率获得2-(2-氯乙基)噻吩
参考文献:三苯基膦/ 2,3-二氯-5,6-二氰基苯并醌是一种新的,选择性的中性体系,可在卤离子存在下将醇,硫醇和硒醇轻松转化为卤代烷
标题:三苯基膦/ 2,3-二氯-5,6-二氰基苯并醌是一种新的,选择性的中性体系,可在卤离子存在下将醇,硫醇和硒醇轻松转化为卤代烷
摘要:在ch 2 Cl 2中的三苯膦(ph 3 P)和2,3-二氯-5,6-二氰基苯并醌的混合物提供了一种络合物,该络合物在r 4 Nx(x = Cl,Br,I)存在下转化为醇,硫醇在室温下以高收率将硒醇和硒醇转化为其相应的烷基卤.该方法对于在2°的醇存在下1°醇的转化以及在3°的醇,硫醇,环氧化物,三甲基甲硅烷基和四氢吡喃基醚,1,3二噻烷,二硫化物和酰胺.
Doi:10.1016/s0040-4020(02)01089-X

专利信息

专利号:US-4824532-A
优先权日:1987-01-09
标题:Process for the electrochemical synthesis of carboxylic acids
发明人：MOINGEON MARIE-ODILE; CHAUSSARD JACQUES; TROUPEL MICHEL; SABOUREAU CHRISTOPHE
权利人:AEROSPATIALE
摘要:The invention relates to a process for the electrosynthesis of carboxylic acids of general formula R-COOH in which R is an organic radical by the electrochemical reduction, in the presence of carbon dioxide, of organic compounds corresponding to the general formula R-Y in which R is the above-mentioned organic radical and Y is a hetero atom-containing radical, the hetero atom of the radical Y, chosen from the group consisting of oxygen, nitrogen, sulphur andphosphorus, being directly linked to a carbon atom of the radical R by a single covalent linkage. When the hetero atom is nitrogen or phosphorus, the radical Y is an ammonium or phosphonium radical respectively. The anode, which is consumed during the electrosynthesis, is made of a metal chosen from the group consisting of reducing metals and their alloys, preferably made of magnesium, aluminium or zinc. This process without catalyst is very simple to perform and enables a cell with a single compartment to be employed. The carboxylic acids are commonly employed in the chemical industry, especially as intermediates for the synthesis of pharmaceutical products or of products used in plant protection.

专利号:US-10899773-B2
优先权日:2014-12-19
标 题 :Total synthesis of trioxacarcin DC-45-A2 and preparation of trioxacarcin analogs
发明人：NICOLAOU KYRIACOS C; CAI QUAN
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

专利号:WO-2017100514-A1
优先权日:2015-12-11
标 题:Lipophilic analogs of cj-16264, methods of use, and synthesis thereof
发明人：NICOLAOU KYRIACOS C; RIGOL STEPHAN; PULUKURI KIRAN KUMAR; SHAH AKSHAY
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present disclosure provides compounds and derivatives of CJ-16,264 of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof. In some embodiments, these compounds are used in the treatment of bacterial infections or in the treatment of cancer.

专利号:US-10065924-B2
优先权日:2014-07-22
标 题 :Preparation and biological evaluation of viridicatumtoxin analogs
发明人：NICOLAOU KYRIACOS C; HALE CHRISTOPHER R H; NILEWSKI CHRISTIAN; IOANNIDOU HERAKLIDIA; EL MARROUNI ABDELLATIF
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

专利号:US-10456400-B2
优先权日:2014-05-17
标 题:Aza-ellipticine analogs, methods of synthesis and methods of treatment
发明人：LINDSEY CHRISTOPHER C; BEESON CRAIG C
权利人:MUSC FOUND FOR RES DEV
摘要:In some aspects, the present invention relates to aza-ellipticine compounds of the formula: wherein the variables are as defined herein. The application also provides novel methods of preparing aza-ellipticine compounds, methods of using the compounds, and pharmaceutical compositions thereof.

专利号:SI-22383-A
优先权日:2006-09-22
标 题:A new process for the synthesis of clopidogrel and a novel form of its pharmaceutically acceptable salts