CAS: 24502-78-1; (R)-1-(5,8-Dihydroxy-1,4-Dioxo-1,4-Dihydronaphthalen-2-yl)-4-Methylpent-3-En-1-Yl Acetate

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CAS号517-89-5 紫草素 | CAS号64-19-7 冰醋酸 | CAS号108-24-7 乙酸酐 | CAS号517-89-5 紫草素 | CAS号77386-93-7 naphthazarin-di... | CAS号80186-91-0 cycloalkannin l...

紫草素,溶剂黄146置于4-二甲氨基吡啶,N,N'-二环己基碳二亚胺体系中,用 二氯甲烷 用作溶剂,以83%的收率获得乙酰紫草素
参考文献:氟酰基紫草素抗癌剂的设计与合成
标题:氟酰基紫草素抗癌剂的设计与合成
摘要:合成了一系列在紫草素侧链上被各种氟化羧酸选择性酰化的紫草素衍生物,并对其抗癌活性进行了评估,其中首次报道了八种化合物.在所有测试的化合物中,化合物s7对b16-F10(恶性黑色素瘤细胞),Mg63(人骨肉瘤细胞)和a549(肺癌细胞)显示出最有效的抗癌活性,Ic 50为0.39+/-0.01,0.72+/-0.04和0.58 +/-0.02 µmol / L.进行化合物s7的对接模拟以将s7定位在微管蛋白活性位点,以确定可能的结合构象.所有结果表明,化合物s7可能是潜在的抗癌药.手性25:757-762,2013.©2013 Wiley Periodicals,Inc.
Doi:10.1002/chir.22209

专利信息

专利号:WO-2023203374-A1
优先权日:2022-04-20
标 题 :[1,2]selenazolo[2,3-a]pyridin-8-ium inhibitors of pyruvate kinase isoform m2
发明人：ARSENJANS PAVELS; DIMITRIJEVS PAVELS; MAKRECKA-KUKA MARINA
权利人:LATVIAN INST ORGANIC SYNTHESIS
摘要:The present invention relates to a novel isoselenazolopyridinium salts as anticancer agents by inhibiting pyruvate kinase isoform M2 (PKM2) activity, as well as methods of their manufacturing and use in different pharmaceutical compositions for the treatment of various diseases and disorders by administration of such substances.

专利号:US-2019314312-A1
优先权日:2016-07-11
标题 :Combination therapy to increase endogenous nitric oxide (no) synthesis
发明人：EREZ AYELET; STETTNER NOA
权利人:YEDA RES & DEV
摘要:Provided are uses of a therapeutically effective amount of citrulline for the manufacture of a medicament for treatment of a subject having an inflammatory bowel disease (IBD) and/or colon cancer. Also provided are pharmaceutical compositions comprising a therapeutic effective amount of citrulline and a therapeutically effective amount of a flavonoid for the treatment of an inflammatory bowel disease (IBD) and/or colon cancer and kits comprising same.

专利号:KR-102686376-B1
优先权日:2022-09-01
标 题 :Carbon quantum dots based on by-products of gromwell root and a method for synthesis of carbon quantum dots based on by-products of gromwell root