CAS: 40134-18-7; Methyl 2-Chloronicotinate

该化合物是一种有机化合物,其特点是其环状结构,由六人组成的芳香环组成,内含一个氮原子.该化合物的特点是一个与甲醇一起被浸泡的碳boxylic酸功能组,导致甲基酯.在双方圆环的2位置上存在氯原子,这引起了独特的再活动,影响其化学特性,如极度和溶解性.一般而言,该化合物的颜色无色性可粉色,可粉黄黄色液体或固体,取决于其纯度和温度.该化合物在乙醇和二氯甲烷等有机溶液溶液溶解剂中溶解,但由于芳香性很强,因此在芳香环的防水性性质下溶解性有限.3-Pyridineboxylicylicary酸,2-C-甲基酯经常用于有机合成,在生产中可以作为中间中间媒介,例如,处理这种化合物的化合物的防腐化剂时,安全可能是.

英文名称Methyl 2-Chloronicotinate
中文名称2-氯烟酸甲酯
IUPAC名称methyl 2-chloronicotinate
其它别名2-氯-3-吡啶甲酸甲酯; Methyl 2-Chloro-3-Pyridinecarboxylate
CAS编号40134-18-7
MFCD编号:MFCD01318629
EINECS号:254-805-9
分子式:C7H6ClNO2
分子量:171.58
产品CID: 1413552
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
产品信息参考
InChIKey: MYGAJZBZLONIBZ-UHFFFAOYSA-N
InChI=1S/C7H6ClNO2/c1-11-7(10)5-3-2-4-9-6(5)8/h2-4H,1H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数1.0

相似化合物

2942-59-8 36404-88-3 42330-59-6

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别严重眼刺激类别2
皮肤腐蚀/刺激类别2
特定目标器官毒性 - 单次接触类别3
严重眼刺激类别2A
警示词Warning(警告)
危险描述H319 |造成严重眼刺激.
H315 |造成皮肤刺激.
H335 |可能引起呼吸道刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
UN编号NONH for all modes of transport
危险品标志Xi
风险等级Irritant/Keep Cold
安全声明26
危险类别码36
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 Methyl 2-Chloronicotinate 主要起始原料 Methanol And 2-Chloronicotinic Acid
(文献来源)合成步骤主要原料 Methanol 和 2-Chloronicotinic Acid

2-氯烟酸置于氯化亚砜,三乙胺体系中,化学反应 2.5H,反应生成 2-氯烟酸甲酯
参考文献:由2-(n-三苯基磷杂亚基)氨基烟酸甲酯,异氰酸芳基酯和伯胺一锅合成新型(2-氧-1,2-二氢吡啶-3-基)-1,3,5-三嗪衍生物:顺序氮杂-维蒂希/环加成/环转化反应
标题:由2-(n-三苯基磷杂亚基)氨基烟酸甲酯,异氰酸芳基酯和伯胺一锅合成新型(2-氧-1,2-二氢吡啶-3-基)-1,3,5-三嗪衍生物:顺序氮杂-维蒂希/环加成/环转化反应
摘要:通过分子间的氮杂-Wittig反应,意外地获得了(2-氧-1,2-二氢吡啶-3-基)-1,3,5-三嗪衍生物10,而不是吡啶并[2,3-D]嘧啶衍生物. 2-(n-三苯基正膦亚基)氨基烟酸甲酯3与芳基异氰酸酯的反应,然后尝试使用伯胺进行杂环化.一种新颖的顺序氮杂维蒂希/环加成/环变换机构,用于形成10已经报道基于所述隔离和关键中间体的表征,吡啶并[1,2一个] [1,3,5]三嗪15形成的通过最初生产的碳二亚胺与异氰酸芳基酯的[4 + 2]环加成反应.
DOI:10.1016/s0040-4020(97)10064-3

海关参考信息

2912110000-甲醛
2915110000-甲酸
2933310010-吡啶
2909199090-其他醚及其衍生物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-8686157-B2
优先权日:2003-02-10
标题:Processes for the facile synthesis of diaryl amines and analogues thereof
发明人：SNOONIAN JOHN R; OLIVER-SHAFFER PATRICIA ANN
权利人:SNOONIAN JOHN R; OLIVER-SHAFFER PATRICIA ANN; VERTEX PHARMA
摘要:The present invention relates to processes for the facile synthesis of diaryl amines and analogues thereof. The processes of the present invention produce diaryl amines in high yield and purity. The present invention also relates to intermediates useful in the process of the present invention.

专利号:WO-2023122754-A1
优先权日:2021-12-23
标题 :Processes and intermediates for preparing gb13, gb22 and himgaline
发明人：LANDWEHR ELEANOR; SHENVI RYAN; BAKER MEGHAN; OGUMA TAKUYA
权利人:SCRIPPS RESEARCH INST
摘要:Provided herein are processes for the streamlined synthesis of Galbulimima alkaloids, such as himbadine, isolated from Galbulimima belgraveana and G. baccatta, trees endemic to the rainforests of Northern Australia and Papua New Guinea, as well as analogs thereof, such as GB13, GB16, GB22, and himgaline, and further including intermediates useful in the synthesis of these and related compounds.

专利号:US-2010004245-A1
优先权日:2006-10-20
标题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-2007173649-A1
优先权日:2003-02-10
标题:Processes for the facile synthesis of diaryl amines and analogues thereof

专利号:US-8034950-B2
优先权日:2003-02-10
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专利号:US-2012157684-A1
优先权日:2003-02-10
标题:Processes for the facile synthesis of diaryl amines and analogues thereof