CAS: 4795-29-3; Tetrahydrofurfurylamine

上下游产品

CAS号494-47-3 三呋喃甲醛二亚胺 | CAS号97-99-4 四氢糠醇 | CAS号98-01-1 糠醛 | CAS号617-89-0 糠胺 | CAS号3003-84-7 四氢呋喃氯 | CAS号1121-47-7 2-呋喃甲醛肟 | CAS号60-29-7 乙醚 | CAS号82166-21-0 2-methyl cyclohexane | CAS号64-17-5 乙醇 | CAS号39089-62-8 2-氯-N-(四氢呋喃-2-甲基)乙酰胺 | CAS号36810-87-4 异硫氰酸氢糠酯 | CAS号90322-18-2 3-[(四氢呋喃-2-甲基)氨基]丙腈 | CAS号26116-10-9 2-[(四氢-2-呋喃)甲基]... | CAS号97-99-4 四氢糠醇 | CAS号4221-03-8 5-羟基戊醛 | CAS号7681-84-7 四氢-2-呋喃甲醛 | CAS号62922-45-6 2,5-二氯戊胺盐酸盐 | CAS号7202-43-9 (R)-2-四氢糠胺 | CAS号4795-29-3 2-四氢糠胺

四氢糠醇置于氨,盐酸体系中,用 2-甲基-2-丁醇,乙醚 作为反应溶剂,170.0 °C,700.01 Kpa 条件下,反应 18.0H,以45.1%的收率获得产物2-四氢糠胺
参考文献:在 Raney® Ni 催化下,通过醇中间体的直接胺化从木质纤维素中产生伯胺
标题:在 Raney® Ni 催化下,通过醇中间体的直接胺化从木质纤维素中产生伯胺
摘要:伯胺是合成各种工业相关产品的极其重要的组成部分.我们在此提出的全面催化策略允许以简单的方式和最少的纯化工作从木质纤维素生物质中获取多种伯胺.该方法的核心是通过两阶段lignoflex工艺获得的醇中间体(即烷基酚衍生物以及脂肪醇)的高效 Raney® Ni 催化借氢胺化(与氨).铜掺杂多孔金属氧化物(cu20Pmo)催化还原催化分馏(Rcf)将松木纤维素转化为富含二氢松柏醇(1G)的粗生物油,该生物油可以高选择性地转化为二氢松柏胺(1G胺)氨气,通过应用我们的选择性胺化方案.还值得注意的是,粗rcf油直接以 4.6 Wt% 的高分离产率(基于木质素含量)提供1G 胺.最后还表明,这里开发的镍催化多相催化程序同样能够将一系列脂肪族直链/环状伯/仲醇(可从lignoflex程序的第二阶段获得)转化为各自的伯胺.
DOI:10.1039/d2Cy00864E

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:WO-0140193-A1
优先权日:1999-12-03
标题:Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
权利人:CHEMRX ADVANCED TECHNOLOGIES I; BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula (I). Also claimed are novel intermediates and their methods of synthesis.

专利号:WO-03031376-A1
优先权日:2001-10-12
标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one
发明人：MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F
摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.

专利号:US-2002103381-A1
优先权日:2000-11-30
标 题 :Method for the synthesis of pyrazolines
发明人：BOLDI ARMEN M
摘要:The present invention provides a method for the synthesis of compounds of Formula I: n n n Also claimed are novel intermediates and their methods of synthesis.

专利号:US-7138526-B1
优先权日:1999-06-15
标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives
发明人：HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M
权利人:AVENTIS PHARMA INC
摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries

专利号:WO-9931124-A1
优先权日:1997-12-12
标 题:Cholic acid-based scaffolds for multidimensional molecular presentation of peptides
发明人：HOEEG-JENSEN THOMAS
权利人:NOVO NORDISK AS; HOEEG JENSEN THOMAS
摘要:A solid phase method for the synthesis of a plurality of differently substituted cholic acid scaffolds with a wide variety of peptide chain, pseudo-peptide chain or peptoid chain substitutents, as leads or compounds of potential therapeutic interest. The substituted cholic acids are prepared by initial solution synthesis of a scaffold holding amino acids with 3 orthogonal protecting groups. Subsequent solid-phase synthesis provides the build-up of the target molecules, either as discretes or in mixture. The molecules may be screened on the resin or cleaved from the resin and then screened in solution. The method disclosed here provides an easy and fast access to highly diverse compounds, potential peptide mimetics and potential leads for compounds of therapeutic interest. The method is amenable to automatization.