专利号:US-2413493-A 优先权日:1943-06-03 标题:Synthesis of isomer-free benzyl methyl acetoacetic methyl ester 发明人:FLISIK ALVIN C; LEONARD NICHOLL; BITLER WILLIAM P 权利人:KAY FRIES CHEMICALS INC
专利号:US-2008281105-A1 优先权日:2005-01-18 标题:Novel Quinolinium Salts and Derivatives 发明人:MACDONALD JAMES E; HYSELL MICHELLE K; YU DEHUA; LI HENRY; WONG-STAAL FLOSSIE 权利人:IMMUSOL INC 摘要:The present invention relates generally to the synthesis of novel quinolinium salts and derivative compounds. Such salts and compounds are useful for inhibiting the growth of cancer cells.
专利号:US-9403766-B2 优先权日:2008-01-17 标 题:Intermediates for producing NEP inhibitors or prodrugs thereof 发明人:HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO 权利人:HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO; NOVARTIS AG 摘要:The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, n nwherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.
专利号:RU-2072991-C1 优先权日:1991-10-09 标题:3-phenylpyrazole derivatives, method of synthesis of 3-phenylpyrazole derivatives and fungicide composition
专利号:US-2017275287-A1 优先权日:2014-08-22 标 题 :Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof 发明人:LIPFORD GRAYSON B; ZEPP CHARLES M 权利人:JANUS BIOTHERAPEUTICS INC 摘要:Compounds as immune system modulators bearing a pteridine core are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing autoimmunity disease using the same are described.
专利号:EP-3183251-A1 优先权日:2014-08-22 标题 :Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof
[参考文献]: C S Hui, Et Al. Calcium Release In Frog Cut Twitch Fibers Exposed To Different Ionic Environments Under Voltage Clamp. Biophys J. 1999 Oct;77(4):2123-36. [参考文献]: Doris Ribitsch, Et Al. Engineering Of Choline Oxidase From Arthrobacter Nicotianae For Potential Use As Biological Bleach In Detergents. Appl Microbiol Biotechnol. 2010 Aug;87(5):1743-52. [参考文献]: Emma Denehy, Et Al. Electronic Structure Of The Sulfonyl And Phosphonyl Groups: A Computational And Crystallographic Study. Inorg Chem. 2007 Oct 15;46(21):8871-86. [参考文献]: F S Lamb, Et Al. Endothelium Modulates Anion Channel-Dependent Aortic Contractions To Iodide. Am J Physiol Heart Circ Physiol. 2000 May;278(5):H1527-36. [参考文献]: G Vargas, Et Al. Common Components Of Patch-Clamp Internal Recording Solutions Can Significantly Affect Protein Kinase A Activity. Brain Res. 1999 May 15;828(1-2):169-73.
合成参考文献
摘要:Petursson, S., Science of Synthesis, (2008) 37, 850.