CAS: 614-78-8; (2-Methylphenyl)Thiourea

该化合物是有机化合物,其特征是存在一个与2-甲基苯基混合物相关的硫尿素功能组,通常看起来像是白色的脱白晶状固体,这种化合物在水和酒精等极地溶剂中溶解,表明其极地功能组. (2-甲基苯基)硫尿亚因其在各个领域的应用而著称,包括制药和农用化学化学品,因为它能够作为有机合成的再剂和潜在的生物活动调节器.

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合成工艺路线路线简述

    O-Tolyl-Dithiocarbamic Acid ; Compound With Triethylamine置于ammonium Hydroxide,Copper(Ll) Bromide体系中,用 水,乙酸乙酯 作为反应溶剂,化学反应 3.0H,反应生成 N-邻甲苯基硫脲
    参考文献:Cubr2介导的从二硫代氨基甲酸盐和酮合成2-氨基噻唑
    标题:Cubr2介导的从二硫代氨基甲酸盐和酮合成2-氨基噻唑
    摘要:摘要 在一锅法中,Cubr2 已被用作一种有效的脱硫剂,用于通过原位反应生成的二硫代氨基甲酸盐的 1-取代硫脲与原位反应生成的 α-溴酮缩合合成 2-氨基噻唑.从酮.所有反应均在优化的反应条件下进行,目标产物的产率为 61-95%.
    DOI:10.1080/10426507.2019.1633316

    海关参考信息

    专利信息


    专利号:US-4656291-A
    优先权日:1985-03-15
    标 题 :Process for producing amidine sulfonic acids
    发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
    权利人:MCNEILAB INC
    摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

    专利号:US-4781866-A
    优先权日:1985-03-15
    标题 :Process for producing amidine sulfonic acid intermediates for guanidines
    发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
    权利人:MCNEILAB INC
    摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

    专利号:US-4851094-A
    优先权日:1985-03-15
    标 题:Process for producing amidine sulfonic acid intermediates for guanidines
    发明人:MARYANOFF CYNTHIA A; PLAMPIN JAMES N; STANZIONE ROBIN C
    权利人:MCNEILAB INC
    摘要:An efficient synthesis of quanidines, e.g. of the formula (III), by oxidizing a thiourea, e.g. of the following formula (II): (III) (II) with H2O2 and a molybdenum catalyst to yield an aminoiminomethane sulfonic acid which can then be reacted with an amine followed by optional transamination steps.

    专利号:WO-2023023572-A1
    优先权日:2021-08-19
    标题:Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto
    发明人:BAUM ERICH; CROUSE GARY; DEMETER DAVID; GIAMPIETRO NATALIE; Horty Lindsey; PETKUS JEFFREY; SPARKS THOMAS
    权利人:CORTEVA AGRISCIENCE LLC
    摘要:Provided are compounds having the structure of Formula One or Formula Two: Formula One, or Formula Two. Pesticidal compositions and their uses are disclosed. Also disclosed are methods of synthesis for compounds disclosed herein.

    专利号:CN-218740561-U
    优先权日:2022-09-26
    标 题:A kind of 4-methyl-2-hydrazinobenzothiazole synthesis raw material filtering device

    专利号:CN-108623537-B
    优先权日:2017-05-24
    标题:Synthesis and application of aromatic amine acetylcholinesterase inhibitors containing amine side chain
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    合成参考文献


    摘要:Krishnamoorthy, R., Science of Synthesis Knowledge Updates, (2013) 1, 464.
    摘要:Podlech, J., Science of Synthesis Knowledge Updates, (2019) 1, 400.
    摘要:Aggarwal, P.; Bebbington, M. W. P., Science of Synthesis Knowledge Updates, (2012) 2, 474.
    摘要:National Technical Information Service., AD691-490
    摘要:U.S. Environmental Protection Agency. 1998. Extremely Hazardous Substances (EHS) Chemical Profiles and Emergency First Aid Guides. Washington, D.C.: U.S. Government Printing Office.
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