CAS: 91322-00-8; 2,4,6-Trichloropyrimidin-5-Amine

相似化合物

4359-87-9 5177-27-5 5413-85-4

上下游产品

CAS号4359-87-9 5-硝基-2,4,6-三氯嘧啶 | CAS号55583-59-0 2,5-二氨基-4,6-二氯嘧啶

2,4,6-三氯-5-硝基嘧啶置于铁粉,溶剂黄146体系中,用 甲醇 作为反应溶剂,以89%的收率获得产物5-氨基-2,4,6-三氯嘧啶
参考文献:属于1,2,3-三唑并[4,5-D]嘧啶的替卡格雷类似物的合成及其抗血小板和抗菌活性的研究.
标题:属于1,2,3-三唑并[4,5-D]嘧啶的替卡格雷类似物的合成及其抗血小板和抗菌活性的研究.
摘要:基于最近的观察,抗血小板药替卡格雷和其代谢产物之一对革兰氏阳性菌具有杀菌活性,合成并研究了一系列与替卡格雷相关的1,2,3-三唑并[4,5-D]嘧啶作为推定的抗血小板和抗菌剂.目的是评估解离这两种生物学特性的可能性,并找到表达抗血小板活性且缺乏体外作用的新型1,2,3-三唑并[4,5-D]嘧啶抗菌活性.合成的新化合物是替卡格雷的已知代谢产物以及结构简化的类似物.发现其中一些表达抗血小板活性并失去抗菌活性,支持了两种活性未必联系在一起的观点.
DOI:10.1016/j.Ejmech.2020.112767

专利信息

专利号:US-10676445-B1
优先权日:2019-06-06
标 题:Synthesis of aminopyrimidine-based energetic materials
发明人：WILHELM CHRISTOPHER; FOROHAR FARHAD; SOTO DENISSE
权利人:US NAVY
摘要:A new azido compound, 5-amino-6-chloro-2,4-diazido-pyrimidine, and a process for synthesizing. The synthesis may include reacting 5-amino-2,4,6-trichloropyrimidine and sodium azide. There is an excess molar amount of sodium azide for each chloro fractional molar amount on the 5-amino-2,4,6-trichloropyrimidine. The synthesis is a two phase reaction that is a dispersion. The 5-amino-2,4,6-trichloropyrimidine dissolved in acetone is a liquid phase, and the sodium azide is insoluble in acetone and is a solid phase, that is present in excess of chemical equivalents. The reaction product is soluble in acetone, and the reaction by-product, sodium chloride is also insoluble in acetone, and the crude yield is about 92%. Unreacted sodium azide and formed sodium chloride are removed by filtration.