4-碘吡啶置于甲醇,Copper(L) Iodide,四(三苯基膦)钯,氢气,Potassium Hydroxide,三甲胺体系中,用 乙酸乙酯 用作溶剂,20.0~110.0 °C,100.0 Kpa 条件下,反应 1.66H,反应生成4-乙烯基吡啶 参考文献:Design And Characterization Of A Heterocyclic Electrophilic Fragment Library For The Discovery Of Cysteine-Targeted Covalent Inhibitors 标题:Design And Characterization Of A Heterocyclic Electrophilic Fragment Library For The Discovery Of Cysteine-Targeted Covalent Inhibitors 摘要:通过半胱氨酸反应性和水稳定性测试,对亲电性小杂环片段库进行了表征,结果表明它们有潜力作为共价战斗头. Doi:10.1039/c8Md00327K
专利信息
专利号:US-7514559-B2 优先权日:2004-03-22 标题 :Catalyst for synthesis of 2- and 4-picolines 发明人:DUTTA PASHUPATI; ROY SUBHASH CHANDRA; ROY SHYAM KISHORE; GOSWAMI TARUN KANTI 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a catalyst composite for the synthesis of 2- and 4-picolines and a process for the preparation thereof and use thereof for the synthesis of 2- and 4-Picolines.
专利号:US-4895922-A 优先权日:1988-05-05 标 题 :Low temperature synthesis of polyesteramides 发明人:OGATA NAOYA 权利人:GOODYEAR TIRE & RUBBER 摘要:This invention disclosed a process for the synthesis of polyesteramides. By utilizing the phosphorus containing catalyst systems of the present invention, such polyesteramides can be synthesized at relatively low temperatures. The present invention specifically discloses a process for the synthesis of a polyesteramide which comprises polymerizing at least one diamine, at least one diol, and at least one dicarboxylic acid in the presence of (1) at least one acid acceptor; (2) at least one halogenated organic compound; and (3) at least one phosphorus containing compound selected from the group consisting of (a) triphenylphosphine, (b) triphenylphosphine oxide, (c) triphenylphosphine sulfide, (d) polymeric agents having pendant diphenylphosphine groups, (e) silicon-phosphorus compositions which contain at least one divalent oxygen atom which is bonded directly to a tetravalent silicon atom and a trivalent or pentavalent phosphorus atom; (f) compounds with the structural formula (C 6 H 5 ) 3 P=N-R, wherein R is a hydrogen atom or an alkyl group containing from 1 to 10 carbon atoms; and (g) compounds with the structural formula (C 6 H 5 )PR 1 R 2 wherein R 1 and R 2 can be the same or different, wherein R 1 is selected from the group consisting of alkyl groups containing from 1 to 10 carbon atoms and phenyl groups, and wherein R 2 is an alkyl group containing from 1 to 10 carbon atoms.
专利号:WO-03031376-A1 优先权日:2001-10-12 标 题 :Solid phase synthesis of substituted 1,5-benzodiazepine-2-one and 1,5-benzothiazepine-2-one 发明人:MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 权利人:AVENTIS PHARMA INC; MORTON GEORGE C; SALVINO JOSEPH M; LABAUDINIERE RICHARD F; HERPIN TIMOTHY F 摘要:A solid phase synthetic method for making substituted 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one. The method is useful for synthesis of large numbers of compounds through automated parallel synthesis or combinatorial library generation and is thus important to rapid discovery or new therapeutic agents containing the base structure of 1,5-benzodiazepine-2-one or 1,5-benzothiazepine-2-one.
专利号:US-7138526-B1 优先权日:1999-06-15 标 题 :Solid phase synthesis of n,n-disubstituted diazacycloalkylcarboxy derivatives 发明人:HERPIN TIMOTHY F; MORTON GEORGE C; SALVINO JOSEPH M 权利人:AVENTIS PHARMA INC 摘要:A method for the solid phase synthesis of N,N-disubstituted diazacycloalkylcarboxy derivatives of general formula (I) and (II) is claimed. Examples include piperazine-2-carboxamide. The method is applicable to the synthesis or large combinatorial libraries
专利号:US-6127515-A 优先权日:1997-11-18 标 题:Functionalized resin for the synthesis of amides and peptides 发明人:MANFRE FRANCO; VANASSE BENOIT J; LABAUDINIERE RICHARD F; MORTON GEORGE C 权利人:AVENTIS PHARM PROD INC 摘要:This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR 1 ; and R 1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.
专利号:US-2023119068-A1 优先权日:2020-02-13 标题:Methods for rapid synthesis of pyranoanthocyanins 发明人:ZHU XIAOYI; STRAATHOF NICOLE; MIYAGUSUKU-CRUZADO GONZALO; GIUSTI M MONICA; CANO ISRAEL GARCIA; JIMENEZ-FLORES RAFAEL 权利人:OHIO STATE INNOVATION FOUNDATION 摘要:The present disclosure provides methods for the rapid synthesis of pyranoanthocyanins.
参考文献:10.1007/s12031-010-9333-1 摘要:Yoon JS, Yang H, Kim SH, Sung SH, Kim YC. Limonoids from Dictamnus dasycarpus Protect Against Glutamate-induced Toxicity in Primary Cultured Rat Cortical Cells. Journal of Molecular Neuroscience. 2010 Feb 13;42(1):9–16. doi: 10.1007/s12031-010-9333-1. 参考文献:10.1016/j.chemosphere.2011.06.087 摘要:Sahiner N, Ozay O, Aktas N. Aromatic organic contaminant removal from an aqueous environment by p(4-VP)-based materials. Chemosphere. 2011 Oct;85(5):832–8. doi: 10.1016/j.chemosphere.2011.06.087. 参考文献:10.1021/la2022165 摘要:Wang HL, Sun Q, Chen M, Miyake J, Qian DJ. Layer-by-layer assembly and characterization of multilayers of a manganese porphyrin linked poly(4-vinylpyridinium) derivative and poly(styrenesulfonic acid-o-maleic) acid. Langmuir. 2011 Aug 16;27(16):9880–9. doi: 10.1021/la2022165.