CAS: 152-58-9; Cortodoxone

上下游产品

CAS号640-87-9 孕甾-4-烯-17α,21-二... | CAS号110801-53-1 (8R,10R,13S,Z)-... | CAS号20380-17-0 21-bromo-17α-hy... | CAS号1807-15-4 Pregn-4-ene-3,2... | CAS号1096-38-4 16-去氢黄体酮 | CAS号1097-51-4 沃氏氧化物 | CAS号387-79-1 17α-羟孕烯醇酮 | CAS号2827-40-9 21-bromo-3β,17α... | CAS号84542-27-8 (8R,9S,10R,13S,... | CAS号67-56-1 甲醇 | CAS号50-23-7 氢化可的松 | CAS号53-06-5 可的松 | CAS号63-05-8 雄烯二酮 | CAS号566-35-8 11-表氢化可的松 | CAS号595-18-6 Pregn-4-ene-3,2... | CAS号2899-95-8 20-hydroxycortisol | CAS号1807-15-4 Pregn-4-ene-3,2... | CAS号57-83-0 孕酮； 黄体素； 黄体酮 | CAS号64-85-7 去氧皮质酮 | CAS号302-97-6 3-氧代-雄甾-4-烯-17β-羧酸

在 水,Potassium Carbonate体系中,用 丙酮 用作溶剂,化学反应 72.0H,以70%的收率获得脱氧可的松
参考文献:高效半合成20和21-[13 C]标记的皮质酮:皮质类固醇对皮肤的敏感性研究模型
标题:高效半合成20和21-[13 C]标记的皮质酮:皮质类固醇对皮肤的敏感性研究模型
摘要:描述了一种从市售的andros-4-Ene-3,17-Dione合成皮质酮的异构体的方法.该策略是基于使用的k ¹³ Cn为在位置20和标记¹³ Ch 3因为早期引入[中的位置21 Mgi,在原位产生的,用于标记¹³旨在c]标记,我们的努力可重复的实验程序,相对于含同位素的前体而言,收率很高.在这种半合成的发展过程中,我们注意到对保护基的明智选择至关重要,因为这不仅可能导致混合物或不稳定的中间体,而且还会显着影响反应的输出. 类固醇-药物化学-同位素标记-过敏原合成-保护基
Doi:10.1055/s-0029-1216986

专利信息

专利号:WO-2004113530-A1
优先权日:2003-06-18
标题:Polynucleotide for synthesis of labeled protein
发明人：NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
权利人:MITSUBISHI CHEM CORP; NAKA DAIJI; NAKANO HIROSHI; SHIRATORI MIWA; KOBAYASHI TERUAKI; SUZUKI KATSUHIKO; HASHIMOTO HIDEMI; SASAKI TOORU
摘要:A process for producing a labeled protein, comprising translating a gene template in the presence of a labeled compound having a label portion consisting of a labeled substance and an acceptor portion consisting of a compound capable of binding to the C-terminus of protein synthesized by a translation system. In particular, there are provided a polynucleotide for use in synthesis of labeled protein characterized by having the capability of enhancing labeling efficiency through addition to the 3’ end of a base sequence coding for target protein within the gene template and provided a process for producing a labeled protein that is carried out with the use of the polynucleotide.

专利号:US-2025206743-A1
优先权日:2022-03-25
标 题:Tyk2 inhibitor synthesis and intermediates thereof
发明人：MASSE CRAIG E; PHADKE AVINASH S; LAWSON JON P; LEVY STUART; YANG XIAOWEI; WU GUISHENG; FAN SHUFENG
权利人:TAKEDA PHARMACEUTICALS CO
摘要:Described herein are methods of synthesis of a tyrosine-protein kinase 2 (TYK2) inhibitor and to intermediate compounds of the synthesis and methods of making the intermediates. Also provided are pharmaceutically acceptable compositions including compounds prepared by the synthetic method and methods of treating disorders using the same.

专利号:US-2003068317-A1
优先权日:2001-04-20
标题:High capacity methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon
发明人：LEE WILLIAM; SAITO KYOICHI
摘要:Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.

专利号:US-2008070274-A1
优先权日:2001-12-10
标 题 :High capacity, methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon
发明人：LEE WILLIAM; SAITO KYOICHI
权利人:LEE WILLIAM; SAITO KYOICHI
摘要:Compositions are provided herein comprising a base material having engrafted polymer brushes. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, which confer functional properties to the base material compositions. Methods of using these compositions include deoxygenation of a sample solution, hydrolysis of denaturing agents in a sample solution, resolution of racemic mixtures in a sample solution, and purification, and concentration of target compounds.

专利号:US-8802660-B2
优先权日:2007-03-12
标 题:De novo synthesis of glucocorticoids in the epidermis and its uses and applications
发明人：TOMIC-CANIC MARJANA; BREM HAROLD; SAMUELS HERBERT H
权利人:TOMIC-CANIC MARJANA; BREM HAROLD; SAMUELS HERBERT H; UNIV NEW YORK
摘要:The present invention relates to methods and compositions that control, i.e., antagonize/inhibit or agonize/stimulate, de novo glucocorticoid production in the skin. Such methods and compositions can be used for the prevention and/or treatment of a variety of skin conditions, including inflammation, acute wounds, chronic non-healing wounds, keloid, fibrotic or hypertrophic scars, and epithelial-derived cancer.

专利号:US-2013035307-A1
优先权日:2010-01-26
标 题:Methods for treating or preventing the spread of cancer using semi-synthetic glycosaminoglycosan ethers
发明人：PRESTWICH GLENN D; KENNEDY THOMAS P
权利人:UNIV UTAH RES FOUND; PRESTWICH GLENN D; KENNEDY THOMAS P
摘要:Described herein are methods for the treatment and prevention of tumor metastasis using alkylated and fluoroalkylated semi-synthetic glycosaminoglycan ethers (“SAGEsâ€?). The synthesis of sulfated alkylated and fluoroalkylated SAGEs is also described.