CAS: 1829-32-9; 3-Chloro-2-Hydroxybenzoic Acid

上下游产品

3 -氯- 2 -羟基苯 3-Chlorosalicylaldehyde 1927-94-2
5-溴-3-氯-2-羟基苯甲酸 5-Bromo-3-Chlorosalicylic Acid 2200-85-3
水杨酸 Salicylic Acid 69-72-7
3-氯苯甲酸 3-Chlorobenzoate 535-80-8
5-Bromo-3,6-Dichlorosalicylic Acid
5-溴水杨酸 5-Bromosalicyclic Acid 89-55-4

2,3-二氯苯甲酸置于吡啶,铜,Potassium Carbonate体系中,用 水 用作溶剂,化学反应 2.0H,以85%的收率获得3-氯水杨酸
参考文献:以水用作溶剂由相应的 2-氯苯甲酸合成水杨酸衍生物
标题:以水用作溶剂由相应的 2-氯苯甲酸合成水杨酸衍生物
摘要:摘要 在吡啶作为助催化剂存在下,使用 Ullmann-Goldberg 反应条件可以实现以水用作溶剂的改进的水杨酸合成.以非常好的收率制备了许多水杨酸.
Doi:10.1081/scc-120004857

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5194666-A
优先权日:1992-07-30
标 题 :Process for preparing esters of 3,5,6-trichlorosalicyclic acid
发明人：SEDLAK JOHN A; HIGGINS MARK A; ESSENFELD AMY P
权利人:AMERICAN CYANAMID CO
摘要:An improved process for the synthesis of esters of 3,5,6-trichlorosalicylic acid in quantitative yield comprises reacting the acid with an alcohol under distillation conditions in the presence of a titanium ester or chelate catalyst, whereby byproduct ether formation from the alcohol is suppressed. The process is especially applicable to a process by which salicylic acid is chlorinated first in concentrated sulfuric acid and then with iodine catalyst to make the trichlorosalicylic acid which is extracted and then reacted with an alcohol and a titanium catalyst to make the ester.

专利号:US-4621160-A
优先权日:1983-06-23
标题 :Process for the chlorination of aromatic derivatives
发明人：DESBOIS MICHEL; DISDIER CAMILLE
权利人:RHONE POULENC SPEC CHIM
摘要:A process for the chlorination of aromatic derivatives. The aromatic derivative is reacted with chlorine gas in liquid hydrofluoric acid. The products obtained are useful as intermediates for the synthesis of compounds having a plant-protecting or pharmaceutical activity.

专利号:WO-9106589-A1
优先权日:1989-11-03
标题 :New anti-hiv compounds belonging to aurintricarboxylic acid
发明人：HAUGWITZ RUDIGER D; NARAYANAN VENKATACHALA
权利人:US COMMERCE; PURDUE RESEARCH FOUNDATION
摘要:The invention relates to the synthesis of compounds with anti-retroviral activity. The synthesis of substantially pure aurintricarboxylic acid monomer and structurally defined polymers, analogs and derivatives thereof, is described. The compounds are shown to have potent anti-retroviral activity, particularly against HIV-1.

专利号:US-9751824-B2
优先权日:2013-11-18
标 题:Acetyl salicyclic acid dimers, synthesis thereof, and uses thereof to prevent and treat complement-mediated disorders
发明人：MCGEER PATRICK L; LEE MOONHEE; MCGEER EDITH G
权利人:AURIN BIOTECH INC
摘要:Dimers of acetyl salicylic acid, including 4,4′-diacetoxy-[1,1′-biphenyl]-3,3′-dicarboxylic acid (DAS-1) and 5,5′-methylenebis(2-acetoxybenzoic acid) (DAS-2) are provided. Methods of blocking the C3 convertase stage of the alternative complement pathway, preventing formation of the membrane attack complex of complement, and preventing or treating a complement-mediated disorder in a mammal including the step of administering dimers of acetyl salicylic acid are also provided.

专利号:US-9168248-B2
优先权日:2009-02-17
标 题:Spiro compounds useful as inhibitors of stearoyl-coenzyme A delta-9 desaturase
发明人：LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL
权利人:LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LI CHUN SING; MORADEI OSCAR MIGUEL; MERCK CANADA INC
摘要:Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.