CAS: 26100-51-6; Polylactic Acid

上下游产品

propan-1-ol D-Fructose D-Mannose Glyceraldehydeformic acid-(4-phenylazo-anilide) 2-hydroxy-1-(2-hydroxy-3-isopropyl-6-methyl-phenyl)-propan-1-one lactic acid-(2-benzyloxy-ethyl ester) acetic acid

专利信息

专利号:WO-2020253243-A1
优先权日:2019-06-20
标题:Process method for catalyzed synthesis of lactide with alkali metal compound
发明人：JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; CHEN JINLONG; ZHANG QUANXING
权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD
摘要:The present invention provides a process method for catalyzed synthesis of lactide with an alkali metal compound, comprising: mixing an alkali metal compound with a lactic acid oligomer, and carrying out a cracking reaction to obtain lactide by means of vacuum distillation, wherein the alkali metal compound used is one or a plurality of an alkali metal carbonate, an alkali metal bicarbonate, and an alkali metal hydroxide. Compared with the prior art, the advantages of the present invention is that the alkali metal compound reacts and dissolves quickly after being added to the system avoiding the problem of pipeline blocking due to a catalyst not dissolving, the alkali metal compound used is cheap and readily available, the amount of the catalyst used is small, the yield of the reaction product lactide is greater than 80%, and the reaction is rapid and easy to industrialize.

专利号:WO-2020253244-A1
优先权日:2019-06-20
标 题 :Process for catalytic synthesis of lactide
发明人：JIANG WEI; ZHANG YANKAI; SUN PING; LI AIMIN; ZHANG QUANXING
权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING QUANKAI RES INSTITUTE OF BIOMATERIALS CO LTD
摘要:The present invention provides a process for the catalytic synthesis of lactide, comprising: mixing a lactic acid oligomer with a composite catalyst; and synthesizing lactide under a heating condition, and collecting the product using a vacuum distillation mode. The used composite catalyst is composed of a zinc or tin compound and an alkali metal compound. Compared with the prior art, the advantages of the present invention are that: the used composite catalyst features a high production rate with a small use amount, a low reaction temperature (150-220°C), and a short reaction time (2-5 h), has a single pass yield that may reach 95% or more, reduces energy consumption compared with the prior art, and facilitates industrial implementations.

专利号:US-10604599-B2
优先权日:2018-05-29
标题:Method for green synthesis of uniform- and large-particle-size polystyrene particles
发明人：SHUANG CHENDONG; ZHOU WEIWEI; WANG YUNSHU; LI AIMIN; LI QIMENG; LIU LILI; WANG WEI; ZHANG YI
权利人:NANJING UNIVERSITY OF TECHNOLOGY; NANJING UNIV & YANCHENG ACADEMY OF ENVIRONMENTAL PROTECTION TECHNOLOGY AND ENGINEERING
摘要:A method for green synthesis of uniform- and large-particle-size polystyrene particles, comprising steps of: prepolymerizing styrene at 70â–¡ to 75â–¡ for 1 h to 6 h in advance while stirring, adding divinylbenzene dissolved with initiators to the styrene, and stirring for 10 min to 30 min to obtain oil phase; heating lactic acid or an aqueous solution of lactic acid to 70â–¡ to 80â–¡, adding the oil phase to dispersed phase by a constant-pressure device, maintaining the temperature for 2 h, heating to 80±5â–¡ and then maintaining the temperature for 1 h, and heating to 85±5â–¡ and then maintaining the temperature for 3 h to 6 h, to obtain polystyrene particles with a uniform particle size ranging from 0.7 mm to 2.0 mm.

专利号:WO-2013138200-A1
优先权日:2012-03-13
标 题 :Green chemistry synthesis of the malaria drug amodiaquine and analogs thereof
发明人：FORTUNAK JOSEPH MARIAN; KULKARNI AMOL ANANT; KING CHRISTOPHER
权利人:UNIV HOWARD
摘要:Methods are provided for a green chemistry one-pot synthesis of amodiaquine and amodiaquine analogs. The methods have a lower environmental impact, lower investment cost, reduced amounts of byproducts and impurities, and a shorter synthesis time, compared to current conventional synthesis methods. The methods reduce the total number of steps in the synthesis from four to five down to two, thereby simplifying production; and allow a reduced number of solvents and reagents to be used in production, thereby reducing the waste generated in the synthesis. The methods can reduce the waste to about 3-5 kilograms of waste generated per kilogram of product produced; and surprisingly improve the overall yield from 60-65% to greater than 90% as compared to the current conventional synthesis methods for amodiaquine and its analogs.

专利号:US-7928223-B2
优先权日:2008-06-20
标题:Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
发明人：LERESTIF JEAN-MICHEL; LECOUVE JEAN-PIERRE; BRIGOT DANIEL
权利人:SERVIER LAB
摘要:Process for the synthesis of the compound of formula (I): n n n n n n n n n n Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

专利号:US-10865390-B2
优先权日:2018-02-12
标 题 :Alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols
发明人：NI YE; ZHOU JIEYU; XU GUOCHAO; WANG YUE
权利人:UNIV JIANGNAN
摘要:The present disclosure discloses an alcohol dehydrogenase mutant and application thereof in synthesis of diaryl chiral alcohols, and belongs to the technical field of bioengineering. The alcohol dehydrogenase mutant of the present disclosure has excellent catalytic activity and stereoselectivity, and may efficiently catalyze the preparation of a series of chiral diaryl alcohols in R- and S-configurations. By coupling alcohol dehydrogenase of the present disclosure to glucose dehydrogenase or formate dehydrogenase, the synthesis of chiral diaryl alcohol intermediates of various antihistamines may be achieved. Compared with the prior art, a method for preparing diaryl chiral alcohols through asymmetric catalytic reduction using the alcohol dehydrogenase of the present disclosure has the advantages of simple and convenient operation, high substrate concentration, complete reaction and high product purity, and has great industrial application prospects.