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CAS号92853-69-5 10H-Phenothiaz...

合成工艺路线路线简述

    10H-phenothiazine-10-carbonyl Chloride,2-(1-oxopropyl)-,Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成 丙酰马嗪
    参考文献:Schmitt Et Al.,Bulletin De La Societe Chimique De France,1957,P. 1474,1480
    标题:Schmitt Et Al.,Bulletin De La Societe Chimique De France,1957,P. 1474,1480

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    专利信息


    专利号:US-2023271983-A1
    优先权日:2020-07-29
    标题 :Functionalized isonitriles and products, preparation and uses thereof
    发明人:SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
    权利人:UNIV SANTIAGO COMPOSTELA
    摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

    专利号:US-9617230-B2
    优先权日:2014-12-22
    标题:Creatine prodrugs, compositions and methods of use thereof
    发明人:BRUBAKER WILLIAM F
    权利人:FARMINGTON PHARMA DEV
    摘要:The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.

    专利号:US-11021501-B2
    优先权日:2015-03-30
    标题:Creatine phosphate analog prodrugs, compositions and methods of use thereof
    发明人:BRUBAKER WILLIAM F
    权利人:FARMINGTON PHARMA DEV
    摘要:The invention describes membrane permeable creatine phosphate analog prodrugs, pharmaceutical compositions comprising membrane permeable creatine phosphate analog prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine phosphate analog prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine phosphate analog prodrugs or pharmaceutical compositions thereof.

    专利号:US-2014315720-A1
    优先权日:2012-10-24
    标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
    发明人:FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
    权利人:CELANESE ACETATE LLC
    摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.
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    主要参考文献


    1: Parodi López N, Svensson SA, Lönnbro J, Hoffmann M, Wallerstedt SM. Reliability and validity of the Swedish indicator 'Drugs that should be avoided in older people'-an appraisal of a set of potentially inappropriate medications. Eur J Clin Pharmacol. 2024 Sep;80(9):1285-1293. doi: 10.1007/s00228-024-03700-x. Epub 2024 May 14.
    2: Dahlén E, Bardage C, Tuvendal P, Ljung R. New users of anxiolytics and sedatives in Sweden-Drug type, doses, prescribers' characteristics, and psychiatric comorbidity in more than 750,000 patients. Int J Methods Psychiatr Res. 2024 Mar;33(1):e1998. doi: 10.1002/mpr.1998.
    3: Parodi López N, Svensson SA, Lönnbro J, Hoffmann M, Wallerstedt SM. Läkemedel som bör undvikas till äldre ur medicinskt perspektiv [The indicator »drugs that should be avoided in older people« from a medical perspective – an analysis with the patient in focus]. Lakartidningen. 2023 Nov 14;120:23043. Swedish. 47(6):529-534. doi: 10.1093/jat/bkad025.

    合成参考文献


    摘要:Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 161
    摘要:Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-222
    摘要:The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 1013
    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
    参考文献:10.1016/s0379-0738(01)00632-6
    摘要:Jonasson B, Saldeen T. Citalopram in fatal poisoning cases. Forensic Sci Int. 2002 Mar 28;126(1):1–6. doi: 10.1016/s0379-0738(01)00632-6.
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