CAS: 402-45-9; 4-(Trifluoromethyl)Phenol

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CAS号128796-39-4 4-(三氟甲基)苯硼酸 | CAS号402-43-7 对溴三氟甲苯 | CAS号98-56-6 4-氯三氟甲苯 | CAS号1228447-94-6 iso-propoxydime... | CAS号71597-85-8 4-羟基苯硼酸 | CAS号2926-29-6 三氟代甲烷亚磺酸钠 | CAS号124-38-9 二氧化碳 | CAS号146397-87-7 4-(三氟甲基)苯基三氟甲磺酸酯 | CAS号19254-78-5 [p-(trifluorome... | CAS号328-90-5 对三氟甲基水杨酸 | CAS号3337-62-0 3,5-二溴-4-羟基苯甲酸 | CAS号35852-58-5 3-氯-4-羟基三氟甲苯 | CAS号113281-23-5 4-hydroxy-4-(tr... | CAS号113281-24-6 2-chloro-4-hydr... | CAS号110230-36-9 2-chloro-3,3,3-... | CAS号402-10-8 2-溴-1-甲氧基-4-(三氟甲基)苯 | CAS号39634-42-9 4-(4-(三氟甲基)苯氧基苯酚 | CAS号454-81-9 2-氨基-4-三氟甲基苯酚 | CAS号146397-87-7 4-(三氟甲基)苯基三氟甲磺酸酯

4-硝基三氟甲苯置于(E)-N-羟基-1-(1-甲基-1H-吡咯-2-基)甲亚胺,Potassium Hydroxide体系中,用 二甲基亚砜 作为反应溶剂,以78%的收率获得产物对三氟甲基苯酚
参考文献:未活化硝基芳烃的脱硝羟基化**
标题:未活化硝基芳烃的脱硝羟基化**
摘要:描述了一种在操作简单,无过渡金属的条件下将硝基芳烃转化为苯酚的一步法.这种反硝化功能化方案为传统的三步合成序列提供了一种简洁且经济的替代方案.
DOI:10.1002/chem.202203807

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人：RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-6846957-B2
优先权日:2002-11-22
标题 :Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
发明人：ZELENIN ALEXANDER
权利人:UNIV TEXAS
摘要:The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of 1-phenyl-3-methylamino-2-propen-1-one with sodium borohydride and acetic acid.

专利号:US-6342582-B1
优先权日:1989-12-04
标 题 :Reaction and dissolving medium for peptides and synthesis method using this medium
发明人：GALVEZ MARIE; MAURICE MARIE-FRANCE
权利人:RHODIA CHIMIE SA
摘要:The present invention relates to a reaction and dissolving medium for the synthesis of peptides. This reaction and dissolving medium for peptide synthesis and/or purification comprises a diluent A chosen from a group of water-immiscible solvents and a phenol B. By employing this reaction and dissolving medium, peptides can be synthesized which are useful as medicaments, vaccines, agro-foodstuff products or plant protection products.

专利号:WO-2022155932-A1
优先权日:2021-01-22
标 题:Application of cationic iron(iii) complex containing 1,3-di-tert-butylimidazolium in synthesizing arylbenzyl ether compounds
发明人：SUN HONGMEI; SONG YANLING
权利人:UNIV SOOCHOW
摘要:Disclosed is an application of an iron (III) complex containing 1,3-di-tert-butyl imidazolium cation in synthesizing arylbenzyl ether compounds. Specifically, di-tert-butyl peroxide is used as an oxidant, and a corresponding arylbenzyl ether compound can be synthesized by means of an oxidative coupling reaction between a phenolic compound and a toluene compound. In the present invention, an iron (III) complex is used as a catalyst for the first time, which achieves the oxidative coupling between a phenolic compound and a toluene compound. The foregoing is the first oxidative coupling reaction between a phenolic compound and benzylic C(sp 3 )-H bond, which provides a new method for the synthesis of arylbenzyl ether compounds. Compared with existing synthesis methods, the present invention avoids the use of toxic and polluting halogenated hydrocarbons and strong bases, has better atom economy, and conforms to the development concept of green synthetic chemistry.

专利号:WO-0021917-A1
优先权日:1998-10-13
标题 :Pharmaceutical intermediate for the synthesis of fluoxetine and a process for the preparation thereof
发明人：REITER JOZSEFNE; SIMIG GYULA; MEZEI TIBOR; IMRE JANOS; VERECZKEYNE DONATH GYOERGYI; NAGY KALMAN; NEMETH NORBERT; SZABO TIBOR
权利人:EGYT GYOGYSZERVEGYESZETI GYAR; REITER JOZSEFNE; SIMIG GYULA; MEZEI TIBOR; IMRE JANOS; VERECZKEYNE DONATH GYOERGYI; NAGY KALMAN; NEMETH NORBERT; SZABO TIBOR
摘要:The invention relates to N,N-dimethyl-{3-phenyl-3-[(4-trifluoromethyl)-phenoxy]-propyl-amine}-p-toluenesulfonate of Formula (I) and an improved process for the preparation thereof. The new compound of Formula (I) is a valuable pharmaceutical intermediate useful in the preparation of the antidepressant having the generic name fluoxetine.