CAS: 51781-21-6; Carteolol Hydrochloride

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CAS号51781-06-7 卡替洛尔

5-(2,3-环氧丙氧基)-3,4-二氢喹诺酮,叔丁胺置于盐酸体系中,用 乙醇,丙酮,水 作为反应溶剂,化学反应 8.17H,以84.7%的收率获得产物盐酸卡替洛尔
参考文献:稳定的盐酸卡替洛尔及其制法和眼用药物组 合物
标题:稳定的盐酸卡替洛尔及其制法和眼用药物组 合物
摘要:本发明涉及稳定的盐酸卡替洛尔及其制法和眼用药物组合物.具体的,本发明涉及一种制备盐酸卡替洛尔的方法,其包括如下步骤:制备3‑氨基‑2‑环己烯酮,制备四氢‑2,5(1H,6H)‑喹啉二酮,制备5‑羟基‑3,4‑二氢‑2(1H)‑喹诺酮,制备5‑(2,3‑环氧丙氧基)‑3,4‑二氢‑2(1H)‑喹诺酮,制备盐酸卡替洛尔.进一步的,本发明还提供了一种照本发明方法制备得到的盐酸卡替洛尔原料药,以本发明制得的盐酸卡替洛尔为原料药制备得到的眼用药物组合物,以及本发明制得的盐酸卡替洛尔在制备用于治疗或预防青光眼或高眼压症的药物中的用途.本发明方法具有优异的药学特征例如所制得的原料药和制剂具有优异的稳定性.

专利信息

专利号:US-4535079-A
优先权日:1982-10-20
标题:Alkanolaminoxy derivatives of 3,4-dihydro-2H-1,4-benzothiazin-3-one, their production process, and their pharmaceutical use
发明人：FRAVOLINI ARNALDO
权利人:MEDIOLANUM FARMACEUTICI SRL
摘要:Object of the invention is a class of new organic compounds derived from 1,4-benzothiazine through substitution of an hydrogen atom in position 6, 7 or 8 by an oxypropanolammine radical monosubstituted in N and furthermore a series of new phenyl derivatives of 1,4-benzothiazine, obtained as intermediate in the synthesis of oxypropanolammine derivatives, and process for obtained the new compounds in form suitable for the preparation of pharmaceutical compositions having antihypertensive, vasodilating and antiarrhythmic activity.

专利号:US-7531164-B2
优先权日:2005-10-21
标 题 :Preventing bacterial or viral infectivity and composition containing infection preventing additive
发明人：DAAKA YEHIA; STAMLER JONATHAN S
权利人:UNIV DUKE
摘要:A nitric oxide synthesis inhibitor or nitric oxide scavenger is administered to prevent development of infection, to prevent development of a cancer where overstimulation of a receptor contributes to the cancer development, and to prevent loss of beta agonist responsivity and as a treatment in combination with a receptor blocker. Compositions include nitric oxide synthesis inhibitor or nitric oxide scavenger containing spermicidal compositions, nasal steroid compositions, urinary tract infection prophylaxis compositions, compositions for prophylaxis of EGFR associated cancer and human blood component(s) composition for transfusion.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:US-2012232031-A1
优先权日:2009-10-19
标 题:Injectable formulations for intra-articular or peri-articular administration
发明人：HUTCHINSON JOHN HOWARD; PRASIT PETPIBOON PEPPI; DEARMOND ISABELLE MARGUERITE
权利人:HUTCHINSON JOHN HOWARD; PRASIT PETPIBOON PEPPI; DEARMOND ISABELLE MARGUERITE; PANMIRA PHARMACEUTICALS LLC
摘要:Described herein are injectable formulations for intra-articular or peri-articular administration, wherein the formulation is administered to treat joint pain. An injectable formulation for intra-articular or peri-articular administration disclosed herein comprises a therapeutically-effective amount of a leukotriene synthesis inhibitor compound formulated for intra-articular or peri-articular administration.