CAS: 5975-12-2; 2,4-Dichloro-3-Nitropyridine

相似化合物

173772-63-9 60186-13-2 4487-56-3

上下游产品

CAS号89282-12-2 2,4-二羟基-3-硝基吡啶 | CAS号165547-79-5 2-羟基-3-硝基-4-氯吡啶 | CAS号626-03-9 2,4-二羟基吡啶 | CAS号5466-62-6 4,6-二羟基烟酸 | CAS号6975-44-6 4,6-二羟基烟酸乙酯 | CAS号685542-71-6 3-Pyridinecarbo... | CAS号6317-97-1 4,6-二羟基-5-硝基吡啶-... | CAS号1061318-65-7 2-(2-氯-3-硝基吡啶-4... | CAS号24501-21-1 3-硝基吡啶-2,4-二胺 | CAS号237435-16-4 3-氨基-6-溴-2,4-二氯吡啶 | CAS号52559-11-2 2,3,4-三氨基吡啶 | CAS号629655-23-8 2-氯-3-硝基-4-羟基吡啶 | CAS号1026076-88-9 7-氯-5-甲基-2-苯基-1... | CAS号2770-01-6 4-氯咪唑[4,5-C]吡啶 | CAS号165547-79-5 2-羟基-3-硝基-4-氯吡啶 | CAS号14121-36-9 2,3,4,6-四氯吡啶 | CAS号179056-98-5 2,4-二氯-6-甲基吡啶-3-胺

4,6-二羟基烟酸乙酯置于sodium Hydroxide,水,硝酸,溶剂黄146,三氯氧磷体系中,化学反应生成 2,4-二氯-3-硝基吡啶
参考文献:Koegl Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1948,Vol. 67,P. 29,37
标题:Koegl Et Al.,Recueil Des Travaux Chimiques Des Pays-Bas,1948,Vol. 67,P. 29,37

专利信息

专利号:US-2025101021-A1
优先权日:2022-06-14
标 题:Methods of making tolebrutinib
发明人：BAILLY FRÉDÉRIC; BENELLI CHRISTOPHE; BORIE CYRIL; BOSCH MICHAËL; CABOS CLAUDE; CHARAUDEAU ALEXIS; JANSSENS LAURENCE; PACQUET FRANÇOIS; RODIER FABIEN; SALLÉ LAURENT; SODO ALFRED; VIGNE SYLVIE
权利人:PRINCIPIA BIOPHARMA INC
摘要:Disclosed herein are improved synthetic routes for making (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1 H-imidazo[4,5-c]pyridin-2(3H)-one (tolebrutinbib). Also disclosed herein are novel compounds used in the synthesis of of (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1 H-imidazo[4,5-c]pyridin-2(3H)-one.

专利号:EP-0609960-B1
优先权日:1989-09-15
标 题 :New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase
发明人：MCCARTHY PETER A; HAMANAKA ERNEST S; WALKER FREDERICK J; CHANG GEORGE; TRUONG THIEN
权利人:PFIZER
摘要:Compounds of the formula the pharmaceutically acceptable salts thereof, wherein Q and R<1> are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-5596001-A
优先权日:1993-10-25
标题 :4-aryl-3-(heteroarylureido)quinoline derivatves
发明人：HAMANAKA ERNEST S
权利人:PFIZER
摘要:Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and natiatherosclerosis agents.