CAS: 635-93-8; 5-Chloro-2-Hydroxybenzaldehyde

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CAS号90-02-8 水杨醛 | CAS号50-00-0 甲醛 | CAS号106-48-9 对氯苯酚 | CAS号100-97-0 乌洛托品 | CAS号1570-64-5 4-氯-2-甲基苯酚 | CAS号67-66-3 氯仿 | CAS号1116-76-3 三辛胺 | CAS号7732-18-5 水 | CAS号321-14-2 5-氯代水杨酸 | CAS号108154-54-7 4-(5-chloro-1-b... | CAS号106202-45-3 6-chloro-2-naph... | CAS号108154-50-3 4-(5-chloro-1-b... | CAS号108154-57-0 6-chloro-4-(5-c... | CAS号321-14-2 5-氯代水杨酸 | CAS号306935-54-6 6-氯-2H-二苯并呋喃-3-羰酰氯 | CAS号38220-75-6 1-(5-溴苯并呋喃-2-基)乙酮 | CAS号55877-79-7 5-氯-2-甲氧基苯甲腈 | CAS号14440-47-2 (4-氯-2-甲酰基苯氧基)乙酸 | CAS号141266-44-6 EM20-25

5-氯代水杨酸置于palladium On Barium Sulfate 吡啶,喹啉,氯化亚砜,氢气,Sulfur体系中,用 甲苯,Petroleum Ether 作为反应溶剂,化学反应生成 5-氯代水杨醛
参考文献:Coumarins. Iii. A Novel Synthesis Ofo-Hydroxybenzaldehydes
标题:Coumarins. Iii. A Novel Synthesis Ofo-Hydroxybenzaldehydes
摘要:在温和温度下,水杨酰氯的催化氢化反应获得了高产率的水杨醛.对取代水杨酰氯进行类似的部分还原也获得了相应的水杨醛,产率可观.然而,尝试制备其他异构体羟基苯酰氯却未能成功.文中讨论了水杨酰氯的结构与其转化为水杨醛的难易程度之间的关系.此外,还描述了用二氯甲基甲醚对 Phenol 进行甲酰化的过程以及选择性 Ortho-甲酰化的相关信息.
DOI:10.1246/bcsj.40.1428

专利信息

专利号:US-4780504-A
优先权日:1985-06-20
标 题 :Supports useful in solid phase synthesis of oligonucleotides
发明人：BUENDIA JEAN; NIERAT JEANINE
权利人:ROUSSEL UCLAF
摘要:Novel supports useful in solid phase synthesis of oligonucleotides of the formula I +TR wherein &cir& is micro pellets of a material selected from the group consisting of glass, silica, Kieselguhr, polytetrafluoroethylene, cellulose and metallic oxides, m is an integer from 1 to 20, A is selected from the group consisting of alkylene of 1 to 20 carbon atoms, saturated cycloalkylene of 3 to 12 carbon atoms, phenyl and 5 to 6 member heterocycles, x is an integer from 0 to 20, x1 is an integer from 0 to 10 and the amino group may be in the m-, p- or o-position, a process for the preparation of said supports, the use of said supports and intermediates.

专利号:US-7026339-B2
优先权日:2003-11-07
标题 :Inhibitors of HCV NS5B polymerase
发明人：YANG FAN; ZHANG BO; WICNIENSKI NANCY ANNE; PFEFFERKORN JEFFREY ALLEN; GREENE MEREDITH L; CHEN KE; NUGENT RICHARD A; REDING MATTHEW TODD; KELLY ROBERT CHARLES; MITCHELL MARK A; FUNK LEE A; HEIER III RICHARD FREDERICK; ANDERSON REBECCA MERRY
权利人:YANG FAN; ZHANG BO; WICNIENSKI NANCY ANNE; PFEFFERKORN JEFFREY ALLEN; GREENE MEREDITH L; CHEN KE; NUGENT RICHARD A; REDING MATTHEW TODD; KELLY ROBERT CHARLES; MITCHELL MARK A; FUNK LEE A; HEIER III RICHARD FREDERICK; ANDERSON REBECCA MERRY
摘要:The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.

专利号:US-2009247618-A1
优先权日:2008-03-26
标题 :Process for preparation of benzo-fused heteroaryl derivatives
发明人：BALLENTINE SCOTT A; REANY LAURA
权利人:BALLENTINE SCOTT A; REANY LAURA
摘要:The present invention is directed to processes for the preparation of benzo-fused heteroaryl derivatives, useful for the treatment of epilepsy and related disorders. The present invention is further directed to processes for the preparation of intermediates in the synthesis of the benzo-fused heteroaryl derivatives.

专利号:US-2013274466-A1
优先权日:2010-09-27
标 题:Process for the preparation of tetracyclic derivatives and intermediate products used in the process
发明人：GORIN BORIS; DIXON CRAIG EDWARD; QU YANG
权利人:GORIN BORIS; DIXON CRAIG EDWARD; QU YANG; ALPHORA RES INC
摘要:A process for preparation of a compound of formula I or a pharmaceutically acceptable salt thereof, is disclosed. The process involves subjecting a compound of formula II to Ullmann-type conditions to effect an intra-molecular ring closure reaction to form the compound of formula I. The different substituents are as described in the specification. Further, the process can provide an alternate route for the synthesis of asenapine from starting materials that can be readily available.

专利号:US-9371334-B2
优先权日:2010-09-22
标题:Synthesis of substituted salicylaldehyde derivatives
发明人：FARMER JAY J; JOB GABRIEL E
权利人:NOVOMER INC
摘要:Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a).

专利号:US-4197408-A
优先权日:1975-08-01
标 题 :Asymmetric synthesis of alkyl chrysanthemate
发明人：ARATANI TADATOSHI; FUJITA FUMIO; NAGASE TSUNEYUKI; YONEYOSHI YUKIO
权利人:SUMITOMO CHEMICAL CO
摘要:A process for the production of an optically active chrysanthemate which comprises reacting 2,5-dimethyl-2,4-hexadiene with a diazoacetate of the formula: n n N.sub.2 CHCOOR n n wherein R is selected from the group consisting of (a) cycloalkyl group with or without substituent(s) whose total carbon atom number is 5-20, (b) tertiary aralkyl group whose carbon atom number is 9 to 20, and (c) tertiary alkyl group with or without alkoxy substituent(s) whose total carbon atom number is 4-20, in the presence of a copper complex coordinated with a chiral Schiff base of the formula: ##STR1## wherein C* is an asymmetric carbon atom, R 1 is selected from the group consisting of (a) alkyl groups whose carbon atom number is 1-10 and (b) aralkyl groups with or without alkoxy substituent(s), whose total carbon atom number is 7-20, R 2 is selected from aryl groups with alkoxy substituent(s), whose total carbon atom number is 7-30, and each of X 1 and X 2 is selected from the group consisting of (a) hydrogen atom, (b) alkyl groups having 1-10 carbon atoms, (c) phenyl group, (d) alkoxy groups having 1-10 carbon atoms, (e) halogen atoms and (f) nitro group, or (g) X 1 and X 2 together form a benzo group.