CAS: 7170-38-9; 3-Penoxypropionic Acid

该化合物是一种多用途有机化合物,其分子式为C9H10O3,其特征是附于丙氧酸链的苯氧基组;这种碳本体酸衍生物通常用作合成药品,农用化学品和特殊化学品的中间体;其反应式碳本体组可进一步发挥功能,使其对生产酯类,胺类和其他衍生物具有价值;复合物在标准条件下显示有机溶剂中具有中等溶性,稳定性,便于其在各种合成用途中的使用;其结构特征也有助于其设计生物活性分子的作用,特别是在研制除草剂和制药前体方面的作用.

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β-Propiolactone sodium phenoxide phenol 3-iodopropanoic acid 2,3-dihydro-4H-1-benzopyran-4-one 3-(4-chlorophenoxy)propionic acid 3-phenoxypropyonic chloride 3-phenoxy-propionic acid amide

合成工艺路线路线简述

    3-苯氧基丙腈置于盐酸体系中,化学反应 3.0H,以85%的收率获得产物3-苯氧基丙酸
    参考文献:热气相消除β-取代羧酸的动力学和机理
    标题:热气相消除β-取代羧酸的动力学和机理
    摘要:3-苯氧基丙酸(1),3-(苯硫基)丙酸(2)和4-苯基丁酸(3)在520至682 K之间热解.热解产物的分析表明消除产物为丙烯酸,而相应的消除产物为丙烯酸.芳烃.还研究了3-苯氧基丙酸乙酯(4)及其甲基类似物(5),3-(苯硫基)丙酸乙酯(6)及其甲基对应物(7)和3-苯氧基丙烷腈(8)的热解过程. K.热气相消除动力学和产物分析与涉及四元循环过渡态的热逆迈克尔反应路径相容.
    DOI:10.1016/j.Tet.2005.04.031

    海关参考信息

    专利信息


    专利号:WO-2013087821-A1
    优先权日:2011-12-15
    标题:Overproduction of jasmonates in transgenic plants
    发明人:CHAMPION ANTONY
    权利人:INST RECH DEVELOPPEMENT IRD
    摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.

    专利号:US-8034966-B1
    优先权日:2008-02-20
    标 题:Phenoxyisobutyric acid compounds and methods for synthesis
    发明人:LALEZARI IRAJ; FABRICANT JILL
    权利人:CELL VIABLE CORP
    摘要:The present invention provides a process for the synthesis of substituted arylureidophenoxymethylpropionic acid and related compounds including bifunctional and tetrafunctional derivatives. The compounds are useful for inhibiting the formation of AGEs (Aminaglycation end products).

    专利号:US-4033949-A
    优先权日:1976-04-14
    标 题:Analogs of thromboxane B2 and processes for their synthesis
    发明人:KELLY ROBERT C; NELSON NORMAN A
    权利人:UPJOHN CO
    摘要:The present specification provides novel intermediates and novel processes for the synthesis of various side chain and skeletal analogs of Thromboxane B 2 (11β-homo-11a-oxa-PGF 2 .sub.α). These analogs are particularly and especially useful as reproductive cycle control agents.

    专利号:US-9040553-B2
    优先权日:2010-09-17
    标题:Phenoxyisobutyric acid compounds and method of synthesis
    发明人:LALEZARI IRAJ; FABRICANT JILL
    权利人:LALEZARI IRAJ; FABRICANT JILL; CELL VIABLE CORP
    摘要:The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).

    专利号:US-2014371316-A1
    优先权日:2011-11-23
    标 题:Derivatives of phenoxyisobutyric acid
    发明人:LALEZARI IRAJ; FABRICANT JILL S
    权利人:FABRICANT JILL S; LALEZARI IRAJ
    摘要:The present invention provides a process for the synthesis of substituted phenoxymethylpropiomc acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced Glycation End Products).

    专利号:US-7390801-B2
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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    主要参考文献

    [参考文献]: Wayne D Vaccaro, Et Al. Novel Histamine H3 Receptor Antagonists Based On The 4-[(1H-Imidazol-4-Yl)Methyl]Piperidine Scaffold. Bioorg Med Chem Lett. 2006 Jan 15;16(2):395-9.

    合成参考文献


    摘要:Hollmann, F., Science of Synthesis Knowledge Updates, (2021) 3, 437.
    摘要:K. Bowden, M. Hardy and D. C. Parkin, Can. J. Chem. 46, 2929 (1968).
    摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 299.
    参考文献:10.1021/tx034127o
    摘要:Sidenius U, Skonberg C, Olsen J, Hansen SH. In vitro reactivity of carboxylic acid-CoA thioesters with glutathione. Chem Res Toxicol. 2004 Jan;17(1):75–81. doi: 10.1021/tx034127o.
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