CAS: 771-69-7; 1,2,3-Trifluoro-4-Nitrobenzene

上下游产品

1,3-dichloro-2-fluoro-4-nitrobenzene 1,2,3-trifluorobenzene 3,4,5-trifluoro aniline 1,3-dichloro-2-fluorobenzene 2,3-difluoro-1-methoxy-4-nitrobenzene 1,2-difluoro-3-methoxy-4-nitrobenzene 2-fluoro-1,3-dimethoxy-4-nitrobenzene 2,3-difluoro-6-nitrophenol

2,3-二氯硝基苯置于potassium Fluoride,硫酸,硝酸,氯体系中,化学反应 10.5H,反应生成 2,3,4-三氟硝基苯
参考文献:一种以邻二氯苯为原料联产喹诺酮类药物关键 中间体的方法
标题:一种以邻二氯苯为原料联产喹诺酮类药物关键 中间体的方法
摘要:本发明涉及医药中间体的制备方法领域,特别是涉及喹诺酮类药物关键中间体的制备方法领域,开发了一种以邻二氯苯为原料联产喹诺酮类药物关键中间体的方法.本发明方法以邻二氯苯为原料,硝化后经精馏提纯再分步结晶得到2,3-二氯硝基苯和3,4-二氯硝基苯.2,3-二氯硝基苯经氟化反应得到2-氟-3-氯硝基苯,然后氯化得到2,6-二氯氟苯,再硝化得到2,4-二氯-3-氟硝基苯,最后氟化得到2,3,4-三氟硝基苯.3,4-二氯硝基苯经氟化反应得到4-氟-3-氯硝基苯,然后氯化得到2,4-二氯氟苯,最后与乙酰氯发生酰化反应得到2,4-二氯-5-氟苯乙酮.

专利信息

专利号:US-6229055-B1
优先权日:1996-04-12
标题 :Synthesis of fluorinated xanthene derivatives
发明人：KLAUBERT DIETER H; GEE KYLE R
权利人:MOLECULAR PROBES INC
摘要:Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.

专利号:US-6448449-B2
优先权日:2000-04-21
标题:Process for preparation of (R)-1- (aryloxy)propan-2-ol
发明人：LARROW JAY FRANCIS
权利人:RHODIA CHIREX INC
摘要:A process for the preparation of (R)-1-(2,3-difluoro-6-nitrophenoxy)-propan-2-ol, which is a useful intermediate in the synthesis of the widely used antibiotic Levofloxacin is provided. A process for the preparation of (R)-1-(2,3-difluoro-6-nitrophenoxy)-2-trimethylsiloxypropane is also described. The process includes the ring opening of (R)-propylene oxide with 2,3-difluoro-6-nitrophenyl trimethylsilyl ether in the presence of an optically active Co(salen) catalyst. The trimethylsilyl group of the reactant is transferred to the product aryloxy alcohol, which serves to protect the secondary alcohol in situ. Upon isolation, the trimethylsilyl group is removed and the resulting regioisomeric mixture purified to yield the desired (R)-1-(2,3-difluoro-6-nitrophenoxy)-propan-2-ol in high purity and yield.

专利号:CN-101811973-A
优先权日:2010-04-23
标 题 :A method for the synthesis of halogenated arylamines by highly selective liquid-phase hydrogenation under solvent-free conditions

专利号:CN-117486670-B
优先权日:2023-12-29
标题:A kind of synthesis method of 3,4,5-trifluorobromobenzene

专利号:CN-1055927-C
优先权日:1997-11-18
标 题:Synthesis and application of levofloxacin analogs

专利号:CN-102603718-B
优先权日:2012-02-08
标 题:Synthesis method of cediranib