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CAS号10036-47-2 四氟(代)肼 | CAS号354-67-6 pentafluoro(1,1... | CAS号113250-69-4 chlorodifluoros... | CAS号7783-81-5 六氟化铀 | CAS号5714-22-7 五氟化硫 | CAS号7782-41-4 氟 | CAS号7704-34-9 硫磺 | CAS号7664-39-3 氟化氢 | CAS号7783-06-4 硫化氢 | CAS号7783-41-7 二氟化氧 | CAS号379-52-2 三苯基氟化锡 | CAS号71-43-2 苯 | CAS号10544-50-0 1,2,3,4,5,6,7,8... | CAS号7647-19-0 五氟化磷 | CAS号463-58-1 羰基硫 | CAS号353-50-4 氟光气 | CAS号2551-62-4 六氟化硫 | CAS号75-73-0 四氟化碳 | CAS号371-78-8 trifluoro(trifl... | CAS号372-64-5 双(三氟甲基)二硫化物

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    专利号:WO-2022256490-A9
    优先权日:2021-06-03
    标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
    发明人:LOCKWOOD MARK
    权利人:ANTIOS THERAPEUTICS INC
    摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

    专利号:US-9896336-B2
    优先权日:2008-06-11
    标 题:Bromine-facilitated synthesis of fluoro-sulfur compounds
    发明人:WINTER ROLF
    权利人:AVANTBIO CORP
    摘要:Described herein are methods for the bromine-facilitated synthesis of fluoro-sulfur compounds, that include SF 4 , SF 5 Cl, SF 5 Br and SF 6 . The methods described herein generally require lower temperature and pressure, produce higher yields, require less time, do not use corrosive or costly reactants and solvents that are commonly used in the synthesis of the fluoro-sulfur compounds, and do not produce deleterious waste products when compared to previously-used methods.

    专利号:US-4705904-A
    优先权日:1984-02-14
    标 题:Vapor phase synthesis of hexafluoroisobutylene
    发明人:BONFIELD JOHN H; ULMER HARRY E
    权利人:ALLIED CORP
    摘要:A vapor phase synthesis of hexafluoroisobutylene, which comprises contacting in the vapor phase in a catalyst zone, B, of a reactor hexafluoropropylene oxide with a fluorinated catalyst such as fluorinated silica-alumina at a temperature of about 400°-600° C. for a residence time sufficient to form a vapor stream comprising hexafluoroacetone which is thereafter directly contacted in a heating zone of the reactor with a vapor stream comprising a keytone-generating compound such as acetic anhydride at a temperature of about 500°-700° C. for a residence time sufficient to form a stream comprising hexafluoroisobutylene, substantially-free of perfluoroisobutylene and recovering the hexafluoroisobutylene product is disclosed. A direct one reactor vapor phase synthesis of hexafluoroisobutylene which comprises (a) contacting, in the vapor phase, hexafluoropropene with less than a stoichiometric amount of oxygen required to convert substantially all the hexafluoroisopropene into hexafluoropropylene oxide in the presence of a fluorinated catalyst such as fluorinated silica-alumina at a temperature of about 400°-600° C. for a time sufficient to form a vapor stream comprising hexafluoropropylene oxide substantially-free of oxygen; (b) directly contacting said vapor stream, in a catalyst zone, B, containing a fluorinated catalyst which is preferably the same as used in catalyst zone, A, at a temperature of about 400°-650°, preferably about 500°-650° C. for a time sufficient to form a vapor stream comprising hexafluoroacetone; (c) directly contacting the vapor stream comprising hexafluroacetone with a vaporized compound such as acetic anhydride at a temperature of about 500°-700° C., preferably about 600° C. for a time sufficient to form a vapor stream comprising hexafluoroisobutylene, substantially-free of perfluoroisobutylene; and (d) recovering hexafluoroisobutylene is also disclosed.

    专利号:US-9079818-B2
    优先权日:2007-10-15
    标 题 :Process for synthesis of fluorinated olefins
    发明人:MUKHOPADHYAY SUDIP; BORTZ CHERYL L; LIGHT BARBARA A; CANTLON CHERYL L; JOHNSON ROBERT C
    权利人:MUKHOPADHYAY SUDIP; BORTZ CHERYL L; LIGHT BARBARA A; CANTLON CHERYL L; JOHNSON ROBERT C; HONEYWELL INT INC
    摘要:Disclosed is a process for the synthesis of fluorinated olefins, and in particularly preferred embodiments tetrafluorinated olefins having F on an unsaturated, non-terminal carbon, such as 2,3,3,3-tetrafluoropropene. The preferred processes of the present invention in accordance with one embodiment generally comprise:n (a) reacting a compound of formula (I)n nX 1 X 2   (I)n nwith a compound of formula (II)n nCX 1 X 2 X 3 CX 1 â•?CX 1 X 2   (II)n nto produce a reaction product comprising a compound of formula (III)n nCF 3 CHX 1 CH 2 X 2   (III), andn (b) exposing said compound of formula (III) to reaction conditions effective to convert said compound of formula (III) to a compound of formula (IV)n nCF 3 CZâ•?CH 2   (IV)n nwherein X 1 , X 2 , and X 3 are each independently selected from the group consisting of hydrogen, chlorine, bromine, fluorine and iodine, provided that X 1 and X 2 in formula (I) are not both hydrogen and Z is Cl, I, Br, or F

    专利号:US-4756739-A
    优先权日:1985-12-21
    标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents
    发明人:FUSS ANDREAS; KOCH VOLKER
    权利人:HOECHST AG
    摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.

    专利号:US-7015176-B2
    优先权日:2003-06-03
    标题 :Process for the synthesis of aryl sulfurpentafluorides
    发明人:BAILEY III WADE H; CASTEEL JR WILLIAM J; PESARESI RENO J; PROZONIC FRANK M
    权利人:AIR PROD & CHEM
    摘要:A process is described for the synthesis of an aryl sulfur pentafluoride compound. In one embodiment of the present invention, there is provided a process for preparing an aryl sulfurpentafluoride compound comprising: combining an at least one aryl sulfur compound with a fluorinating agent to at least partially react and form an intermediate aryl sulfurtrifluoride product; and exposing the intermediate aryl sulfurtrifluoride product to the fluorinating agent and optionally a fluoride source to at least partially react and form the aryl sulfurpentafluoride compound.
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    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 392.
    摘要:Aitken, R. A.; Boubalouta, Y., Science of Synthesis Knowledge Updates, (2013) 4, 156.
    摘要:Desroches, J.; Paquin, J.-F., Science of Synthesis Knowledge Updates, (2016) 1, 389.
    摘要:Journal of Occupational Medicine., 4(262), 1962
    摘要:Health Council of the Netherlands: Committee on Updating of Occupational Exposure Limits. Sulphur tetrafluoride; Health-based Reassessment of Administrative Occupational Exposure Limits. The Hague: Health Council of the Netherlands, 2002; 2000/15OSH/039. https://www.gezondheidsraad.nl/sites/default/files/0015039osh_1.pdf
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