CAS: 89-91-8; Methyl 2,2-Dimethoxyacetate

该化合物是属于酯类的有机化合物,其特点是分子式,通常包括碳,氢和氧原子.该化合物无色可粉黄,含有甜,果味的气味,在各种应用中有用,包括作为一种溶剂和合成其他化学品.甲基甲氧氧乙酸酯以其相对低的挥发性和中等溶解性而著称,这可视温度和浓度而异.在正常条件下是稳定的,但应谨慎处理,因为其潜在的刺激性能.在水中可进行水解,从而形成甲醇和甲氧酸.在与该化合物合作时,安全防范至关重要,因为若吸入或摄入,可能会对健康造成危害.

结构式图片

相似化合物

563-96-2 19757-97-2 30934-97-5

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

methanol 2,2-dimethoxyacetic acid Glyoxilic acid dichloro-acetic acid2,4,8,10-tetraoxa-spiro[5.5]undecane-3,9-dicarboxylic acid dimethyl ester 4,4-dimethoxy-3-oxo-butyric acid methyl ester 2,2-dimethoxy-1,1-diphenylethanol 2,2-dimethoxyacetic acid

合成工艺路线路线简述

  • 298-12-4 = 89-91-8
    反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Trimethyl Orthoformate
    标题:About The Ozone Cleavage Of Chloroprene And Of 2-Chloro-3-Methyl-1,3-Butadiene In Methanol
    作者:Griesbaum,Karl; Meister,Martin
    参考文献:Chemische Berichte 日期:1987 卷标:120(9) 页码:1573-80]

    19757-97-2 = 89-91-8
    反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Methanol
    标题:Combinatorial Applications Of N-Acyliminium Ion Intermediates In The Synthesis Of Homoallylic Amines
    作者:Meester,Wilhelmus Johannes Nicolaas
    参考文献:2002]

    563-96-2 = 89-91-8
    反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Monohydrate; 72 H,Rt
    标题:Syntheses Of 3,4-Benzotropolones By Ring-Closing Metatheses
    作者:Arican,Deniz; Brueckner,Reinhard
    参考文献:Organic Letters 日期:2013 卷标:15(11) 页码:2582-2585]

    298-12-4 = 89-91-8
    反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Water; 4 H,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water; Ph 8,Rt
    标题:Study On The Dimethoxyacetic Acid Methyl Ester Synthesis
    作者:Chang,Hong-Hong; Wei,Wen-Long; Liu,Qiang; Li,Yan-Wei
    参考文献:Taiyuan Ligong Daxue Xuebao 日期:2003 卷标:34(4) 页码:447-448]

    298-12-4 = 89-91-8
    反应条件:1.1 Reagents: Sulfuric Acid,Copper Sulfate Solvents: Methanol,Water
    标题:The Development And Application Of New Methods For The Synthesis Of Organozinc Carbenoids
    作者:Popkin,Matthew Edward
    参考文献:1998]

    298-12-4 = 89-91-8
    反应条件:1.1 Reagents: Sulfuric Acid,Water Solvents: Methanol
    标题:3-(2-Pyrrolidinyl)-2,4-Furandione Analogs
    作者:Coppola,Gary M.; Damon,Robert E.
    参考文献:Journal Of Heterocyclic Chemistry 日期:1990 卷标:27(3) 页码:815-17]

    33414-80-1 = 89-91-8 + 113515-17-6
    反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol
    标题:Formation Of 4,6-Dinitro-2-Nitrosoaniline By Intramolecular Redox Reaction Of Esters And Amides Of 2-(2,4,6-Trinitroanilino)Carboxylic Acids
    作者:Machacek,Vladimir; Hassanien,Makky M. M.; Sterba,Vojeslav; Lycka,Antonin
    参考文献:Journal Of The Chemical Society 日期:1987 卷标:(7) 页码:867-73
乙烯,四甲氧基-置于甲酸 水体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 甲醇,二甲氧基乙酸甲酯
参考文献:Kresge,A. J.; Leibovitch,M.; Kopecky,K. R.,Canadian Journal Of Chemistry,1990,Vol. 68,# 10,P. 1786-1790
标题:Kresge,A. J.; Leibovitch,M.; Kopecky,K. R.,Canadian Journal Of Chemistry,1990,Vol. 68,# 10,P. 1786-1790

海关参考信息

专利信息


专利号:US-8357819-B2
优先权日:2007-05-11
标 题 :Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid
发明人:BOITEAU JEAN-GUY
权利人:GALDERMA RES & DEV; BOITEAU JEAN-GUY
摘要:The invention relates to a process for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula (I): n nand also to the process for the synthesis of the reaction intermediates of general formula (XII), and to the said compounds when R2 is chosen from the methyl, trifluoromethyl, phenyl and 4-tolyl radicals:

专利号:US-11926624-B2
优先权日:2018-06-29
标 题:Synthesis of coelenterazine synthesis intermediate
发明人:DUVVURU RAJAGOPALA REDDY
权利人:INT PAPER CO
摘要:Disclosed herein are synthesis methods for coelenterazine and intermediates. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.

专利号:US-11939332-B2
优先权日:2018-06-29
标题:Synthesis of coelenterazine
发明人:DUVVURU RAJAGOPALA REDDY; BHATT RAMA; KUMAR ANIL
权利人:INT PAPER CO
摘要:Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.

专利号:US-9346853-B2
优先权日:2012-06-20
标 题 :Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition
发明人:HOEFERL-PRANTZ KATHRIN; FELZMANN WOLFGANG; WILHELM THORSTEN; BENITO-GARAGORRI DAVID
权利人:SANDOZ AG
摘要:The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.

专利号:US-12415831-B2
优先权日:2019-01-07
标 题:HPLC free purification of peptides by the use of new capping and capture reagents
发明人:BERGMANN FRANK; POMPLUN SEBASTIAN JOHANNES
权利人:ROCHE DIAGNOSTICS OPERATIONS INC
摘要:The present disclosure relates to the use of a capping and capture reagent in solid phase peptide synthesis. The present disclosure further relates to a method of solid phase peptide synthesis, wherein a capping and capture reagent according to the present disclosure is used. The present disclosure further relates to a method for purification of a (full-length) synthetic peptide via use of a capping and capture reagent according to the present disclosure. The present disclosure also relates to a kit comprising a capping and capture reagent according to the present disclosure and an amino oxy resin or a hydrazine resin and the use of the kit.

专利号:US-2021332044-A1
优先权日:2018-06-29
标题:Synthesis of coelenterazine synthesis intermediate
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合成参考文献


摘要:Smith, K. M.; Vicente, M. G. H., Science of Synthesis, (2004) 17, 1095.
摘要:Westbrook, J. A.; Schaus, S. E., Science of Synthesis, (2007) 20, 1123.
摘要:Takeda, T.; Tsubouchi, A., Science of Synthesis, (2007) 30, 158.
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