298-12-4 = 89-91-8 反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Trimethyl Orthoformate 标题:About The Ozone Cleavage Of Chloroprene And Of 2-Chloro-3-Methyl-1,3-Butadiene In Methanol 作者:Griesbaum,Karl; Meister,Martin 参考文献:Chemische Berichte 日期:1987 卷标:120(9) 页码:1573-80]
19757-97-2 = 89-91-8 反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Methanol 标题:Combinatorial Applications Of N-Acyliminium Ion Intermediates In The Synthesis Of Homoallylic Amines 作者:Meester,Wilhelmus Johannes Nicolaas 参考文献:2002]
298-12-4 = 89-91-8 反应条件:1.1 Reagents: Sulfuric Acid,Copper Sulfate Solvents: Methanol,Water 标题:The Development And Application Of New Methods For The Synthesis Of Organozinc Carbenoids 作者:Popkin,Matthew Edward 参考文献:1998]
298-12-4 = 89-91-8 反应条件:1.1 Reagents: Sulfuric Acid,Water Solvents: Methanol 标题:3-(2-Pyrrolidinyl)-2,4-Furandione Analogs 作者:Coppola,Gary M.; Damon,Robert E. 参考文献:Journal Of Heterocyclic Chemistry 日期:1990 卷标:27(3) 页码:815-17]
33414-80-1 = 89-91-8 + 113515-17-6 反应条件:1.1 Reagents: Sodium Methoxide Solvents: Methanol 标题:Formation Of 4,6-Dinitro-2-Nitrosoaniline By Intramolecular Redox Reaction Of Esters And Amides Of 2-(2,4,6-Trinitroanilino)Carboxylic Acids 作者:Machacek,Vladimir; Hassanien,Makky M. M.; Sterba,Vojeslav; Lycka,Antonin 参考文献:Journal Of The Chemical Society 日期:1987 卷标:(7) 页码:867-73
专利号:US-8357819-B2 优先权日:2007-05-11 标 题 :Method for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methyl-ureido)-biphenyl-4-yl]-2-methoxy-acrylic acid 发明人:BOITEAU JEAN-GUY 权利人:GALDERMA RES & DEV; BOITEAU JEAN-GUY 摘要:The invention relates to a process for the synthesis of (Z)-3-[2-butoxy-3′-(3-heptyl-1-methylureido)biphenyl-4-yl]-2-methoxyacrylic acid of formula (I): n nand also to the process for the synthesis of the reaction intermediates of general formula (XII), and to the said compounds when R2 is chosen from the methyl, trifluoromethyl, phenyl and 4-tolyl radicals:
专利号:US-11926624-B2 优先权日:2018-06-29 标 题:Synthesis of coelenterazine synthesis intermediate 发明人:DUVVURU RAJAGOPALA REDDY 权利人:INT PAPER CO 摘要:Disclosed herein are synthesis methods for coelenterazine and intermediates. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.
专利号:US-11939332-B2 优先权日:2018-06-29 标题:Synthesis of coelenterazine 发明人:DUVVURU RAJAGOPALA REDDY; BHATT RAMA; KUMAR ANIL 权利人:INT PAPER CO 摘要:Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.
专利号:US-9346853-B2 优先权日:2012-06-20 标 题 :Synthesis of telaprevir and boceprevir, or pharmaceutically acceptable salts or solvates as well as intermediate products thereof including β-amino acids prepared via Mukaiyama aldol addition 发明人:HOEFERL-PRANTZ KATHRIN; FELZMANN WOLFGANG; WILHELM THORSTEN; BENITO-GARAGORRI DAVID 权利人:SANDOZ AG 摘要:The invention relates to synthetic routes for preparing telaprevir and boceprevir, and its intermediates as well as peptides other than telaprevir. The synthetic routes are based on a Mukaiyama aldol addition reaction of a silyl enol ether or an enolate with an imine. The invention also refers to novel intermediates for preparing telaprevir/boceprevir or other peptides.
专利号:US-12415831-B2 优先权日:2019-01-07 标 题:HPLC free purification of peptides by the use of new capping and capture reagents 发明人:BERGMANN FRANK; POMPLUN SEBASTIAN JOHANNES 权利人:ROCHE DIAGNOSTICS OPERATIONS INC 摘要:The present disclosure relates to the use of a capping and capture reagent in solid phase peptide synthesis. The present disclosure further relates to a method of solid phase peptide synthesis, wherein a capping and capture reagent according to the present disclosure is used. The present disclosure further relates to a method for purification of a (full-length) synthetic peptide via use of a capping and capture reagent according to the present disclosure. The present disclosure also relates to a kit comprising a capping and capture reagent according to the present disclosure and an amino oxy resin or a hydrazine resin and the use of the kit.
专利号:US-2021332044-A1 优先权日:2018-06-29 标题:Synthesis of coelenterazine synthesis intermediate
摘要:Smith, K. M.; Vicente, M. G. H., Science of Synthesis, (2004) 17, 1095. 摘要:Westbrook, J. A.; Schaus, S. E., Science of Synthesis, (2007) 20, 1123. 摘要:Takeda, T.; Tsubouchi, A., Science of Synthesis, (2007) 30, 158.