CAS: 1122-91-4; 4-Bromobenzaldehyde

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CAS号58928-91-9 2-(4-bromopheny... | CAS号873-75-6 4-溴苄醇 | CAS号201230-82-2 carbon monoxide | CAS号589-87-7 对溴碘苯 | CAS号586-75-4 4-溴苯甲酰氯 | CAS号106-38-7 对溴甲苯 | CAS号87199-17-5 4-甲酰基苯硼酸 | CAS号25062-46-8 4-BROMOBENZALDE... | CAS号120445-43-4 2-(4-bromobenzy... | CAS号106736-05-4 4-Bromo-N-(2-me... | CAS号1092389-35-9 4-[(4-bromophen... | CAS号110929-20-9 (4-bromophenyl)... | CAS号1072220-37-1 (1S,2S)-(+)-[N,... | CAS号111729-78-3 2-[(4-bromophen... | CAS号105114-53-2 2-(4-bromopheny... | CAS号3592-12-9 5,5-二甲-1,3-二恶烷-2-酮 | CAS号110677-45-7 4-(9H-咔唑-9-基)苯甲醛 | CAS号105515-33-1 3-(4-BROMOPHENY... | CAS号106948-05-4 2,3-EPOXY-3-(4-...

4-溴苯腈置于lithium Diisobutylmorpholinoaluminum Hydride体系中,用 四氢呋喃,正己烷 用作溶剂,化学反应 0.5H,以95%的收率获得对溴苯甲醛
参考文献:二异丁基吗啉铝氢化物锂 (Ldbmoa) 作为叔酰胺和腈的有效部分还原剂
标题:二异丁基吗啉铝氢化物锂 (Ldbmoa) 作为叔酰胺和腈的有效部分还原剂
摘要:将羧酸衍生物直接还原为醛是有机合成中的有用工具.已经报道了许多从羧酸衍生物如酰氯,酯,酰胺和腈制备醛的合成方法.我们开发并报道了一种由二异丁基氢化铝 (Dibalh) 简单制备的新型部分还原剂,在温和的反应条件下以有用的收率将羧酸衍生物顺利还原为醛.1 由羧酸衍生物直接合成醛而无需氧化步骤的方法是有机合成中重要且有价值的工具.作为我们旨在通过对商业 Dibalh 进行简单修改来发现新还原剂的研究计划的一部分,我们最近发现二异丁基吗啉铝氢化物锂 (Ldbmoa) 很容易通过在室温下在 Thf 中使等摩尔量的吗啉锂与 Dibalh 反应来制备(方案 1).以前,我们已经评估了该试剂的还原特性,用于将代表性羧酸衍生物部分还原为醛(表 1).幸运的是,我们发现了在 0 O C 下以非常好的收率将叔酰胺和腈部分还原为醛的可能性.我们试图通过 N,N-二甲基苯甲酰胺和苄腈作为 Ldbmoa 的模型化合物(表
Doi:10.5012/bkcs.2012.33.12.4194

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-11512303-B2
优先权日:2017-05-27
标 题 :Engineered polypeptides and their applications in the synthesis of beta-hydroxy-alpha-amino acids
发明人：CHEN HAIBIN; BONG YONG KOY; XU QING; ZHOU AMENG; SHEN TIANRAN; YANG JIADONG; YANG ZHUHONG
权利人:ENZYMASTER NINGBO BIO ENG CO LTD
摘要:The present invention provides engineered polypeptides that are useful for the asymmetric synthesis of β-hydroxy-α-amino acids under industrial-relevant conditions. The engineered polypeptides disclosed in this invention were developed through directed evolution based on the ability of catalytic synthesis of (2S, 3R)-2-amino-3-hydroxy-3-(4-nitrophenyl) propanoic acid. The present disclosure also provides polynucleotides encoding engineered polypeptides, host cells capable of expressing engineered polypeptides, and methods of producing β-hydroxy-α-amino acids using engineered polypeptides. Compared to other processes of preparation, the use of the engineered polypeptides of the present invention for the preparation of β-hydroxy-α-amino acids results in high purity of the desired stereoisomers, mild reaction conditions, low pollution and low energy consumption. So, it has good industrial application prospects.

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-8410320-B2
优先权日:2010-12-07
标 题 :Method for synthesis of secondary alcohols
发明人：CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI
权利人:CHENG CHIEN-HONG; KARTHIKEYAN JAGANATHAN; HUANG PANG-CHI; NAT UNIV TSING HUA
摘要:A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.

专利号:US-10913749-B2
优先权日:2015-05-07
标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-11136335-B2
优先权日:2016-06-30
标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.