专利号:US-10005720-B2 优先权日:2013-04-05 标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same 发明人:SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L 权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL 摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-5877330-A 优先权日:1995-06-08 标 题:Vanadium-containing catalysts, process for manufacturing and use of the same 发明人:KISHIMOTO NOBUJI; MATSUNAMI ETSUSHIGE 权利人:NIPPON CATALYTIC CHEM IND 摘要:PCT No. PCT/JP96/01547 Sec. 371 Date Jan. 29, 1997 Sec. 102(e) Date Jan. 29, 1997 PCT Filed Jun. 7, 1996 PCT Pub. No. WO96/41678 PCT Pub. Date Dec. 27, 1996Vanadium-containing catalysts are obtained by using polyvanadic acid as a source of vanadium. Vanadium-containing catalysts are obtained by mixing catalyst components other than vanadium, or their precursors, with a polyvanadic acid sol which is formed by ion-exchanging a metavanadic acid aqueous solution with a proton-type cation-exchange resin and performing polycondensation, and by drying and/or calcining the mixture. Such vanadium-containing catalysts can fully exhibit their catalytic activity under mild reaction conditions, and can be suitably used for various reactions, such as synthesis of phthalic anhydride by the partial oxidation of o-xylene, synthesis of benzaldehyde by the partial oxidation of toluene, synthesis of benzoic acid by the partial oxidation of toluene, synthesis of anisaldehyde by the partial oxidation of p-methoxy toluene, synthesis of propylene by the oxidative dehydrogenation of propane, synthesis of isobutene by the oxidative dehydrogenation of isobutane, synthesis of methyl formate by the oxidative dehydrogenation of methanol, and synthesis of acrylonitrile by the ammoxidation of propane.
专利号:US-6281378-B1 优先权日:1995-06-08 标 题 :Vanadium-containing catalysts, process for manufacturing and use of the same 发明人:KISHIMOTO NOBUJI; MATSUNAMI ETSUSHIGE 权利人:NIPPON CATALYTIC CHEM IND 摘要:Vanadium-containing catalysts are obtained by using polyvanadic acid as a source of vanadium. Vanadium-containing catalysts are obtained by mixing catalyst components other than vanadium, or their precursors, with a polyvanadic acid sol which is formed by ion-exchanging a metavanadic acid aqueous solution with a proton-type cation-exchange resin and performing polycondensation, and by drying and/or calcining the mixture. Such vanadium-containing catalysts can fully exhibit their catalytic activity under mild reaction conditions, and can be suitably used for various reactions, such as synthesis of phthalic anhydride by the partial oxidation of o-xylene, synthesis of benzaldehyde by the partial oxidation of toluene, synthesis of benzoic acid by the partial oxidation of toluene, synthesis of anisaldehyde by the partial oxidation of p-methoxy toluene, synthesis of propylene by the oxidative dehydrogenation of propane, synthesis of isobutene by the oxidative dehydrogenation of isobutane, synthesis of methyl formate by the oxidative dehydrogenation of methanol, and synthesis of acrylonitrile by the ammoxidation of propane.
专利号:US-2004044225-A1 优先权日:2001-06-01 标 题:Chiral and achiral synthesis of 2-acyl substituted chromanes and their derivatives 发明人:KANTER JAMES; MARLOWE CHARLES; PANDEY ANJALI; MULLINS JOHN J G; SCARBOROUGH ROBERT; BUTKE GREG; JACOBSON BARRY; WALKER DEREK 摘要:Disclosed are processes for producing a (2S) or (2R) 4-oxo-chroman-2-yl acyl compounds and chroman-2-yl acyl compounds, esters or amides thereof as well as derivatives thereof. Such processes may involve chiral synthesis or achiral synthesis, preferably coupled with a resolution procedure. Such compounds, particularly (2S) or (2R) acetic acid esters, are useful intermedates for producing platelet aggregation inhibitors and/or are themselves potent platelet aggregation inhibitors. Further disclosed are processes for making derivatives of such substantially pure, or enhanced compositions of single (2R) or (2S) enantiomer intermediates or processes for producing final products or salts from such desired enantiomers.
专利号:US-11655158-B2 优先权日:2019-10-14 标题 :Isomorphous substitution of metals during the synthesis of a zeolite framework 发明人:MINTOVA Svetlana; GILSON JEAN-PIERRE; NESTERENKO NIKOLAI; MINOUX DELPHINE; AQUINO CINDY; GRAND JULIEN; DUBRAY FLORENT 权利人:TOTALENERGIES ONETECH; CENTRE NAT RECH SCIENT 摘要:The present disclosure relates to a novel staged-synthesis method for introduction of various metals in the structure of zeolite frameworks by isomorphous substitution. This new method is based on a hydrothermal synthesis in which the metal addition to the precursor suspensions (gel) is delayed. This so-called “staged-synthesis method†allows to obtain nanosized silanol highly homo-geneous crystalline zeolite structures with a control of the metal location.
专利号:US-10577387-B1 优先权日:2018-08-09 标题 :Platinum (II) complexes containing N-heterocyclic carbene ligand and pincer ligands, synthesis, and their applications in cancer treatment 发明人:CHE CHI MING; Fung Sin Ki; Chen tian feng 权利人:UNIV HONG KONG 摘要:Provided herein is a method of synthesis of Pt(II) complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Pt(II) complexes. Also provided is a method of detecting the Pt(II) complex in a biological system. Also provided is a method of making the Pt(II) complex The Pt(II) complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, and inhibition of tumor growth in vivo.
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