环丙甲酸置于硫酸体系中,用 甲醇 用作溶剂,化学反应生成环丙甲酸甲酯 参考文献:Processes For The Preparation Of Cyclopropanecarboxylic Acid And 标题:Processes For The Preparation Of Cyclopropanecarboxylic Acid And 摘要:本发明公开了一种使用分子氧作为氧化剂,通过非催化氧化环丙基甲醛制备环丙基甲酸的方法.同时,本发明还公开了从环丙基甲酸制备酰胺,酯和酸氯化物的方法.
专利号:US-9695169-B2 优先权日:2012-05-31 标 题:Synthesis of heterocyclic compounds 发明人:IBRAHIM PRABHA N 权利人:PLEXXIKON INC 摘要:Provided herein are intermediates and processes useful for facile synthesis of biologically active molecules.
专利号:US-2023303611-A1 优先权日:2022-01-21 标题:Synthesis of an antiviral azasugar triphosphate 发明人:KOTIAN PRAVIN L; Dang zhao; WU MINWAN 权利人:BIOCRYST PHARM INC 摘要:Provided are methods of making the active 5′-triphosphate form of galidesivir (compound 1) and the active 5′-triphosphate form of azasugar nucleoside analogues (compound 2):a potent anti-viral compound useful for broad spectrum treatment, suppression, and prevention of viral infections. The syntheses of compound 1 and compound 2 can be achieved via selective formation of protected intermediate 1b and protected intermediate 2b, respectively:
专利号:EP-1495142-B1 优先权日:2002-04-17 标 题:'doping' in walk-through mutagenesis 发明人:CREA ROBERTO; CAPPUCCILLI GUIDO 权利人:BIOREN INC; CAPPUCCILLI GUIDO 摘要:A method of walk-through mutagenesis of a nucleic acid encoding a prototype polypeptide of interest, is described, the method comprising selecting a predetermined amino acid and one or more target regions of the polypeptide, and synthesizing a mixture of oligonucleotides containing at each sequence position in the target region, either a prototype nucleotide that is required for synthesis of the prototype amino acid of the polypeptide, or a predetermined nucleotide that is required for synthesis of the predetermined amino acid, in which during the synthesis, the ratio of available prototype nucleotides, to available predetermined nucleotides, is greater than 1:1.
专利号:US-5942632-A 优先权日:1995-07-28 标题:Solid phase synthesis method 发明人:WANG GARY T 权利人:ABBOTT LAB 摘要:A solid phase synthesis method and intermediates useful in the process are disclosed for the preparation of diamino diol and diamino alcohol inhibitors of HIV protease.
专利号:US-2015368243-A1 优先权日:2012-05-31 标题:Synthesis of heterocyclic compounds
专利号:US-2014094611-A1 优先权日:2012-05-31 标题 :Synthesis of heterocyclic compounds