CAS: 394-28-5; 2-Bromo-5-Fluorobenzoic Acid

上下游产品

CAS号446-08-2 2-氨基-5-氟苯甲酸 | CAS号452-63-1 2-溴-5-氟甲苯 | CAS号202865-66-5 2-溴-5-氟苄醇 | CAS号124-38-9 二氧化碳 | CAS号460-00-4 对氟溴苯 | CAS号352-70-5 3-氟甲苯 | CAS号1055331-73-1 2-溴-5-氟-3-硝基苯甲酸 | CAS号446-08-2 2-氨基-5-氟苯甲酸 | CAS号884497-46-5 3-氨基-5-氟苯甲酸甲酯 | CAS号6942-39-8 2-溴-5-氟苯甲酸甲酯 | CAS号1006-34-4 2-溴-5-氟苯甲酰胺 | CAS号1006-33-3 2'-溴-5'-氟苯乙酮 | CAS号112399-50-5 2-溴-5-氟苄溴 | CAS号111771-13-2 2-溴-5-氟苯甲酰氯 | CAS号136834-55-4 methyl 5-fluoro... | CAS号194473-04-6 6-氟-2-甲基-4-羟基喹唑啉

2-氨基-5-氟苯甲酸置于氢溴酸,Copper(I) Bromide,Sodium Nitrite体系中,用 水 用作溶剂,化学反应 1.0H,以73%的收率获得2-溴-5-氟苯甲酸
参考文献: 2-( (2,3-Dihydroxypropyl) Aminomethyl) Chromane Derivatives For Use As Beta-3 Adrenoreceptor Agonists In The Treatment Of Urological And Inflammatory Disorders[fr] Derives De 2-( (2,3-Dihydroxypropyl) Aminomethyl) Chromane Destines A Etre Utilises En Tant Qu'Agonistes Du Recepteur Adrenergique Beta-3 Dans Le Traitement De Troubles Urologiques Et Inflammatoires
标题: 2-( (2,3-Dihydroxypropyl) Aminomethyl) Chromane Derivatives For Use As Beta-3 Adrenoreceptor Agonists In The Treatment Of Urological And Inflammatory Disorders[fr] Derives De 2-( (2,3-Dihydroxypropyl) Aminomethyl) Chromane Destines A Etre Utilises En Tant Qu'Agonistes Du Recepteur Adrenergique Beta-3 Dans Le Traitement De Troubles Urologiques Et Inflammatoires
摘要:这项发明涉及公式(i)的类胡萝卜素衍生物及其盐,其可用作药物制剂的活性成分.本发明的类胡萝卜素衍生物作为beta 3拮抗剂具有出色的活性,并可用于预防和治疗与beta 3活性相关的疾病,特别是用于治疗泌尿系统紊乱或疾病,如膀胱过度活动(过度活跃膀胱),尿失禁,神经源性膀胱过度活动(膀胱过度反射),特发性膀胱过度活动(膀胱不稳定),良性前列腺增生和下尿路症状;以及炎症性疾病,如哮喘和慢性阻塞性肺病(copd).

专利信息

专利号:US-7968752-B2
优先权日:2003-06-16
标 题:Hydrolytically-resistant boron-containing therapeutics and methods of use
发明人：LEE VING; PLATTNER JACOB J; BENKOVIC STEPHEN J; BAKER STEPHEN J; MAPLES KIRK R; BELLINGER-KAWAHARA CAROLYN; AKAMA TSUTOMU; ZHANG YONG-KANG; SINGH RAJESHWAR; SAURO VITTORIO A
权利人:ANACOR PHARMACEUTICALS INC
摘要:Compositions and methods of use of borole derivatives, including benzoxaboroles, benzazaboroles and benzthiaboroles, as therapeutic agents for treatment of diseases caused by bacteria or viruses are disclosed, as well as methods for synthesis of said agents and compositions thereof.

专利号:CN-119285635-A
优先权日:2024-11-06
标题 :Synthesis of 8H-indolo [3,2,1-DE ] phenanthridine-8-ketone compound from carbazole and o-bromobenzoic acid and synthesis method thereof

专利号:US-2011301143-A1
优先权日:2009-02-23
标题 :Heterocyclic derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
权利人:ISABEL ELISE; LACHANCE NICOLAS; LECLERC JEAN-PHILIPPE; LEGER SERGE; OBALLA RENATA M; POWELL DAVID; RAMTOHUL YEEMAN K; ROY PATRICK; TRANMER GEOFFREY K; ASPIOTIS RENEE; LI LIANHAI; MARTINS EVELYN
摘要:Heterocyclic compounds of structural formula (I), or a pharmaceutically acceptable salt thereof, wherein W is a R1— substituted heteroaryl, R1 is an heteroaryl ring substituted with an ester or carboxylic acid containing radical, X-T is N—CR5R6, Câ•?CR5 or CR13—CR5R6, Y is a bond or —C(O)—, a and b represent an integer selected from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The heterocyclic compounds are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, atherosclerosis, obesity, diabetes, neurological disease, Metabolic Syndrome, insulin resistance, cancer, liver steatosis, and non-alcoholic steatohepatitis.