CAS: 425-61-6; 2,2,3,3-Tetrafluorobutane-1,4-Diol

相似化合物

76-37-9 1220957-89-0 377-71-9

上下游产品

diethyl tetrafluorosuccinate dimethyl tetrafluorosuccinate 2,2,3,3-tetrafluorobutane-1,4-diol diacetate perfluorosuccinic difluoride 5,5,6,6-Tetrafluoro-1,3-dioxacycloheptan 3,3,4,4-tetrafluorooxolane 4-((tert-butyldiphenylsilyl)oxy)-2,2,3,3-tetrafluorobutan-1-ol mono-O-benzyl-2,2,3,3-tetrafluorobutane-1,4-diol

四氟丁二酰氯置于乙醇,Sodium Tetrahydroborate,水,Potassium Hydroxide体系中,化学反应 1.5H,以86.8%的收率获得产物四氟丁二醇
参考文献:一种由含氟环烯烃制备含氟二元醇的方法
标题:一种由含氟环烯烃制备含氟二元醇的方法
摘要:本发明公开了一种由含氟环烯烃制备含氟二元醇的方法,该方法以含氟环烯烃为原料,经氧化剂氧化及强碱处理反应生成含有对应含氟二元羧酸盐的固体混合盐,再经酰氯化试剂作用反应生成对应的含氟二元酰氯,最后含氟二元酰氯在溶剂和催化剂作用下与还原剂发生还原反应,得到对应的含氟二元醇.本发明采用特定的有机溶剂和催化剂,配合其他条件,能够有效促进含氟环烯烃高效率,高收率地反应生成相应的含氟二元醇.该方法具有原料易得,工艺简单,操作方便,耗费成本低等优点,适宜于规模化生产含氟二元醇.

专利信息

专利号:US-7442802-B2
优先权日:2002-06-27
标 题:Cyclooxygenase-2 selective inhibitors, compositions and methods of use
发明人：BANDARAGE UPUL K; EARL RICHARD A; EZAWA MAIKO; FANG XINQIN; GARVEY DAVID S; KHANAPURE SUBHASH P; RANATUNGE RAMANI R; RICHARDSON STEWART K; SCHROEDER JOSEPH D; STEVENSON CHERI A; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one COX-2 selective inhibitor, optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor, and/or, optionally, at least one therapeutic agent. The novel cyclooxygenase 2 selective inhibitors of the invention can be optionally nitrosated and/or nitrosylated. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

专利号:US-6812350-B2
优先权日:2002-06-04
标题:Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds
发明人：HULIN BERNARD
权利人:PFIZER
摘要:The present invention relates to a method of making novel dipeptidyl peptidase-IV (“DPP-IV’) inhibitor compounds useful for treating, inter alia, diseases that are associated with proteins that are subject to processing by DPP-IV, such as Type 2 diabetes mellitus, metabolic syndrome (Syndrome X or insulin resistance syndrome), hyperglycemia, impaired glucose tolerance, glucosuria, metabolic acidosis, cataracts, diabetic neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic cardiomyopathy, Type 1 diabetes, obesity, hypertension, hyperlipidemia, atherosclerosis, osteoporosis, osteopenia, frailty, bone loss, bone fracture, acute coronary syndrome, infertility due to polycystic ovary syndrome, short bowel syndrome and to prevent disease progression in Type 2 diabetes. The invention also relates to a method of making 3,3,4,4-tetrafluoropyrrolidine, a starting material utilized in the afore-mentioned method for preparing DPP-IV compounds.

专利号:US-2004002609-A1
优先权日:2002-06-04
标题:Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds

专利号:US-2004242898-A1
优先权日:2002-06-04
标 题:Synthesis of 3,3,4,4-tetrafluoropyrrolidine and novel dipeptidyl peptidase-IV inhibitor compounds

专利号:US-11613667-B2
优先权日:2017-12-26
标 题:Fluorinate polyacrylate coating composition, the preparation method therefore and use thereof
发明人：SHI ZHENG; WANG JIANHUI; LU JUNBIAO; XU ZHENGLIN; XING SHILI
权利人:AKZO NOBEL COATINGS INT BV
摘要:The embodiments herein relate to a composition of a fluorinated polyurethane acrylate resin and a polyurethane acrylate resin, which, upon curing, is durable and has anti-stain and anti-scratch properties. The preparation of the composition is conducted with a one-pot multicomponent synthesis process, wherein multiple components are put together to carry out reactions simultaneously. The process is especially suitable for industrial scale production, and open for adding additive components to further adjust the performance of the prepared composition. The embodiments herein also relate to oligomers prepared in the synthesis process, as well as the use of the composition or oligomer to form a coating onto a substrate.

专利号:CN-103524394-A
优先权日:2012-07-04
标题:Synthesis method and application of a kind of fluorine-containing nitrogen heterocyclic alkyne liquid crystal compound