CAS: 4891-15-0; Estramustine Phosphate

该化合物是一种氮芥子衍生物,与主要用于治疗前列腺转移癌症的静态醇结合使用,主要用于治疗前列腺转移癌.它作为电动剂发挥作用,干扰癌症细胞的DNA复制.它的独特结构允许选择性地吸收前列腺组织,提高治疗效率,同时尽量减少系统毒性.它通过口服,为病人提供方便.

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    专利号:US-2023382819-A1
    优先权日:2020-10-14
    标 题:Processes for synthesis of alpha-emitting radiopharmaceuticals
    发明人:MORSE DAVID L; WADAS THADDEUS J; PANDYA DARPAN; TAFRESHI NARGES; BUDZEVICH MIKALAI
    权利人:H LEE MOFFITT CANCER CT & RES; UNIV IOWA RES FOUND
    摘要:The present disclosure provides processes for the preparation of alpha emitting radiopharmaceutical compositions, in particular DOTATATE complexes of alpha emitting radionuclides, as well as use of such prepared compositions in the treatment of cancers.

    专利号:US-2024262829-A1
    优先权日:2021-04-21
    标 题:Peptide nucleic acids, synthesis, and uses thereof
    发明人:ROTHMAN JEFFREY
    权利人:ONCOGENUITY INC
    摘要:The present disclosure provides peptide nucleic acids (PNAs) including cyclic structural moieties such as tetrahydrofuran, pyrrolidinium, pyrrolidine, or N-methyl pyrrolidine, which have surprisingly improved the water solubility and binding affinity of PNA oligomers to ribose-phosphate nucleic acid oligomers. Pharmaceutical compositions including the disclosed PNAs, synthetic methods thereof, and methods of use thereof are also disclosed.

    专利号:EP-3049068-A1
    优先权日:2013-09-27
    标题 :Synthesis of silk fibroin micro- and submicron spheres using a co-flow method

    专利号:US-2016215103-A1
    优先权日:2013-09-27
    标题 :Synthesis of silk fibroin micro- and submicron spheres using a co-flow method
    发明人:OMENETTO FIORENZO; PEROTTO GIOVANNI; MARELLI BENEDETTO; KAPLAN DAVID; MITROPOULOS ALEXANDER
    权利人:UNIV TUFTS
    摘要:This application relates to silk fibroin particles that are structurally uniform. Related methods are also disclosed.

    专利号:US-9585890-B2
    优先权日:2012-09-26
    标题 :Modulators of androgen synthesis
    发明人:DILLY SUZANNE; STOLOFF GREGORY; TAYLOR PAUL
    权利人:TANGENT REPROFILING LTD
    摘要:The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.

    专利号:US-9808462-B2
    优先权日:2012-09-26
    标题 :Modulators of androgen synthesis
    发明人:DILLY SUZANNE; STOLOFF GREGORY; TAYLOR PAUL
    权利人:TANGENT REPROFILING LTD
    摘要:The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.
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    主要参考文献


    1: Petrioli R, Roviello G, Fiaschi AI, Laera L, Bianco V, Ponchietti R, Barbanti G, Francini E. Low-Dose Estramustine Phosphate and Concomitant Low-Dose Acetylsalicylic Acid in Heavily Pretreated Patients With Advanced Castration-Resistant Prostate Cancer. Clin Genitourin Cancer. 2015 Oct;13(5):441-6. doi: 10.1016/j.clgc.2015.03.004. Epub 2015 Mar 26. doi: 10.1007/s10147-014-0694-2. Epub 2014 Apr 12. doi: 10.1007/s12032-013-0717-2. Epub 2013 Sep 5. doi: 10.1007/s11255-013-0634-5. Epub 2013 Dec 20. doi: 10.1111/j.1464-410X.2011.10201.x. Epub 2011 Jul 14. Review. doi: 10.1007/s10147-015-0802-y. Epub 2015 Feb 15. doi: 10.1007/s12032-012-0178-z. Epub 2012 Feb 10. doi: 10.1016/j.bmcl.2010.11.117. Epub 2010 Dec 4.
    10: Hatano K, Nishimura K, Nakai Y, Yoshida T, Sato M, Kawashima A, Mukai M, Nagahara A, Uemura M, Oka D, Nakayama M, Takayama H, Shimizu K, Meguro N, Tanigawa T, Yamaguchi S, Tsujimura A, Nonomura N. Weekly low-dose docetaxel combined with estramustine and dexamethasone for Japanese patients with metastatic castration-resistant prostate cancer. Int J Clin Oncol. 2013 Aug;18(4):704-10. doi: 10.1007/s10147-012-0429-1. Epub 2012 Jun 12. Review. doi: 10.1016/j.clgc.2015.08.008. Epub 2015 Sep 2. doi: 10.1007/s10147-011-0275-6. Epub 2011 Jun 25. doi: 10.1186/1477-7819-10-1.
    15: Bergenheim AT, Henriksson R. Pharmacokinetics and pharmacodynamics of estramustine phosphate. Clin Pharmacokinet. 1998 Feb;34(2):163-72. Review.

    合成参考文献


    摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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