专利号:US-2023382819-A1 优先权日:2020-10-14 标 题:Processes for synthesis of alpha-emitting radiopharmaceuticals 发明人:MORSE DAVID L; WADAS THADDEUS J; PANDYA DARPAN; TAFRESHI NARGES; BUDZEVICH MIKALAI 权利人:H LEE MOFFITT CANCER CT & RES; UNIV IOWA RES FOUND 摘要:The present disclosure provides processes for the preparation of alpha emitting radiopharmaceutical compositions, in particular DOTATATE complexes of alpha emitting radionuclides, as well as use of such prepared compositions in the treatment of cancers.
专利号:US-2024262829-A1 优先权日:2021-04-21 标 题:Peptide nucleic acids, synthesis, and uses thereof 发明人:ROTHMAN JEFFREY 权利人:ONCOGENUITY INC 摘要:The present disclosure provides peptide nucleic acids (PNAs) including cyclic structural moieties such as tetrahydrofuran, pyrrolidinium, pyrrolidine, or N-methyl pyrrolidine, which have surprisingly improved the water solubility and binding affinity of PNA oligomers to ribose-phosphate nucleic acid oligomers. Pharmaceutical compositions including the disclosed PNAs, synthetic methods thereof, and methods of use thereof are also disclosed.
专利号:EP-3049068-A1 优先权日:2013-09-27 标题 :Synthesis of silk fibroin micro- and submicron spheres using a co-flow method
专利号:US-2016215103-A1 优先权日:2013-09-27 标题 :Synthesis of silk fibroin micro- and submicron spheres using a co-flow method 发明人:OMENETTO FIORENZO; PEROTTO GIOVANNI; MARELLI BENEDETTO; KAPLAN DAVID; MITROPOULOS ALEXANDER 权利人:UNIV TUFTS 摘要:This application relates to silk fibroin particles that are structurally uniform. Related methods are also disclosed.
专利号:US-9585890-B2 优先权日:2012-09-26 标题 :Modulators of androgen synthesis 发明人:DILLY SUZANNE; STOLOFF GREGORY; TAYLOR PAUL 权利人:TANGENT REPROFILING LTD 摘要:The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.
专利号:US-9808462-B2 优先权日:2012-09-26 标题 :Modulators of androgen synthesis 发明人:DILLY SUZANNE; STOLOFF GREGORY; TAYLOR PAUL 权利人:TANGENT REPROFILING LTD 摘要:The present specification discloses compositions comprising at least one therapeutic compound capable of modulating androgen production and methods and uses for treating a disorder associated with androgen production using such compositions and/or compounds.