CAS: 507-70-0; Borneol

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(+)-9-Bromocamphor置于4-二甲氨基吡啶,1-(Dimethylamino)Naphthaleimide,Aluminum Isopropoxide,三乙胺体系中,用 四氢呋喃,二氯甲烷,异丙醇 作为反应溶剂,化学反应 96.25H,反应生成 (+)-冰片
参考文献:Synthesis And Absolute Configuration Of The Antiparasitic Furanosesquiterpenes (-)-Furodysin And (-)-Furodysinin. Camphor As A Six-Membered Ring Chiral Pool Template
标题:Synthesis And Absolute Configuration Of The Antiparasitic Furanosesquiterpenes (-)-Furodysin And (-)-Furodysinin. Camphor As A Six-Membered Ring Chiral Pool Template
摘要:The Syntheses Of (-)-Furodysin ((-)-2A) And (-)-Furodysinin ((-)-3A) In Four Steps Starting From (+)-9-Bromocamphor (18) Has Been Accomplished,Thus Establishing The Absolute Configuration Of These And Related Metabolites. This Was Made Possible By The Unexpected Exo Selectivity In The Aldol Condensation Of Camphor-Like Enolates With Aldehydes. This Has Been Found To Be A General Phenomenon In The Camphor System. Further,Anionic Fragmentation Of The C1-C7 Bond Of Camphor Derivatives Has Allowed Access To Synthetic Intermediates Containing Functionalized Six-Membered Rings,Thus Opening Up Avenues From Camphor To A New Class Of Chiral Pool Elements Not Currently Available From Chiral Pool Substances.
DOI:10.1021/jo00001A069