CAS: 5370-01-4; 1-(2,6-Dimethylphenoxy)Propan-2-Amine Hydrochloride

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CAS号31828-71-4 美西律 | CAS号89763-88-2 2-Propanamine, ... | CAS号91452-27-6 N-[2-(2,6-Dimet...

1-(2,6-二甲基苯氧基)-2-丙酮置于盐酸,Ammonium Acetate,Sodium Cyanoborohydride体系中,用 甲醇 作为反应溶剂,化学反应 96.0H,反应生成 盐酸美西律
参考文献:美西律类似物的合成,抗心律失常活性和毒理学评估
标题:美西律类似物的合成,抗心律失常活性和毒理学评估
摘要:与母体化合物美西律相比,已测试了四种美西律类似物对离体豚鼠心脏组织的抗心律失常,正性肌力和变时性作用,并评估了钙拮抗剂的活性.所有类似物均显示出中等至较高的抗心律失常活性.特别是,它们中的三个(1B,C,E)比参考药物更具活性和效力,而仅表现出中等程度的或无负性变力和变时作用以及血管舒张活性,因此显示出很高的作用选择性.所有化合物均未显示细胞毒性,并且1B,C,D不会损害运动协调性.总而言之,这些新的类似物表现出有趣的心血管特征,值得进一步研究.
DOI:10.1016/j.Ejmech.2016.05.046

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-2024051897-A1
优先权日:2022-07-26
标题:Synthesis of complex 15n-labeled molecules
发明人：DORSHEIMER JULIA; ROVIS TOMISLAV
权利人:UNIV COLUMBIA
摘要:Methods for conversion of a broad range of amines to their 15N isotopic counterparts and the compounds produced thereby.

专利号:US-9757463-B2
优先权日:2012-06-15
标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures
发明人：HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M
权利人:UNIV VANDERBILT
摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

专利号:WO-2007104357-A1
优先权日:2006-03-14
标 题 :Synthesis of amines with catalytic amounts of mild lewis acids
发明人：NUGENT THOMAS CHRISTOPHER; WAKCHAURE VIJAY NARAYAN; EL-SHAZLY MOHAMED MAHMOUD
权利人:UNIV JACOBS BREMEN GMBH; NUGENT THOMAS CHRISTOPHER; WAKCHAURE VIJAY NARAYAN; EL-SHAZLY MOHAMED MAHMOUD
摘要:The invention relates to methods for producing primary, secondary and tertiary amines and corresponding enantiopure or enantioenriched primary or secondary amine products, comprising the steps of reductively aminating a ketone, with a nitrogen auxiliary in the presence of a hydrogenating catalyst and a hydrogenating agent, wherein the reductive animation is performed under the influence of a mild Lewis acid, the mild Lewis acid being present at the onset of the reductive amination in at most 25 mol% of the ketone or the nitrogen auxiliary.

专利号:US-2007203079-A1
优先权日:2005-11-21
标题:Methods of using small molecule compounds for neuroprotection
发明人：CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
权利人:CALDWELL GUY A; CALDWELL KIM A; CAO SONGSONG
摘要:Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and neuronal loss. In one aspect of the invention, the methods and compositions are also useful for treating neurodegenerative diseases. Small molecule compounds provide an important treatment option because of their stability, ease of use in both manufacture and formulation, ease of administration, and patient compliance. The small molecule compound compositions of the present invention may include topoisomerase II inhibitors, bacterial transpeptidase inhibitors, calcium channel antagonists, cyclooxygenase inhibitors, folic acid synthesis inhibitors, or sodium channel blockers and functional analogues thereof that have an effect on neurodegeneration. The compositions of the present invention may be administered prophylactically before the onset of clinical symptoms or after clinical symptoms of a neurodegenerative disease have manifested.

专利号:US-9018249-B2
优先权日:2011-09-13
标题 :SGLT inhibitors
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; NANDA GURMEET KAUR; THUNGATHURTHI SASTRY V R S; SINGH NISHAN; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising novel compounds of Formula I and methods of treating or preventing one or more conditions or diseases that may be regulated or normalized via inhibition of Sodium Glucose Cotransporter-2 (SGLT-2).