CAS: 587-02-0; 3-Ethylaniline

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CAS号586-39-0 3-硝基苯乙烯 | CAS号121-89-1 3-硝基苯乙酮 | CAS号7369-50-8 1-乙基-3-硝基苯 | CAS号15411-43-5 3-乙烯基苯胺 | CAS号100-41-4 乙苯 | CAS号99-03-6 3'-氨基苯乙酮 | CAS号400-93-1 4'-氟-3'-硝基苯乙酮 | CAS号403-42-9 对氟苯乙酮 | CAS号54509-73-8 ethene | CAS号108-90-7 氯苯 | CAS号34136-57-7 3-乙基苯腈 | CAS号4765-24-6 6-乙基吲哚 | CAS号148582-37-0 4-溴-2-乙基-1-硝基苯 | CAS号19164-77-3 1-乙基-3-碘苯 | CAS号2725-82-8 3-溴乙基苯 | CAS号619-20-5 3-乙基苯甲酸 | CAS号103029-25-0 Ethanone, 1-(4-... | CAS号34934-04-8 n-((3-ethylphen... | CAS号34934-05-9 4-乙基靛红

3-硝基苯乙烯置于iridium,氢气,Silica Gel体系中,用 甲苯 作为反应溶剂,40.0 °C,300.01 Kpa 条件下,反应 1.75H,反应生成 3-乙基苯胺
参考文献:Irfe双金属纳米材料的结构演变和加氢性能
标题:Irfe双金属纳米材料的结构演变和加氢性能
摘要:通过反向微乳液法,合成了一系列具有可变形态和组成的irfe双金属纳米材料,并通过57 Femössbauer光谱,Xrd,Xps和tem对其进行了表征.通过改变ir对fe前驱体的摩尔比,可以简单地调节结构演化,例如在fe 2 O 3薄片上由irfe合金纳米颗粒转变为ir纳米颗粒.就fe而言,随着fe种类的增加,Irfe合金的相对含量降低,而fe 2 O 3的相对含量降低.薄片增加直到达到100%.所制备的irfe双金属纳米材料被用作将3-硝基苯乙烯选择性氢化为3-氨基苯乙烯的催化剂,并且发现催化性能与这些纳米材料的形态和组成有关.ir 1 Fe 4随后被确认为是一种高活性且选择性极强的催化剂,具有非常好的稳定性和可回收性,可用于3-硝基苯乙烯的加氢反应,这突出了两种金属的显着"协同效应",即负载在fe上的ir纳米颗粒的形式2 O 3片.对于ir纳米颗粒,它们充当了氢化的活性物种.用于fe 2
DOI:10.1021/acs.Langmuir.5B04566

专利信息

专利号:US-5877278-A
优先权日:1992-09-24
标题:Synthesis of N-substituted oligomers
发明人：ZUCKERMANN RONALD N; GOFF DANE A; NG SIMON; SPEAR KERRY; SCOTT BARBARA O; SIGMUND AARON C; GOLDSMITH RICHARD A; MARLOWE CHARLES K; PEI YAZHONG; RICHTER LUTZ; SIMON REYNA
权利人:CHIRON CORP
摘要:A solid-phase method for the synthesis of N-substituted oligomers, such as poly (N-substituted glycines) (referred to herein as poly NSGs) is used to obtain oligomers, such as poly NSGs of potential therapeutic interest which poly NSGs can have a wide variety of side-chain substituents. Each N-substituted glycine monomer is assembled from two 'sub-monomers' directly on the solid support. Each cycle of monomer addition consists of two steps: (1) acylation of a secondary amine bound to the support with an acylating agent comprising a leaving group capable of nucleophilic displacement by -NH2, such as a haloacetic acid, and (2) introduction of the side-chain by nucleophilic displacement of the leaving group, such as halogen (as a solid support-bound alpha -haloacetamide) with a sufficient amount of a second sub-monomer comprising an -NH2 group, such as a primary amine, alkoxyamine, semicarbazide, acyl hydrazide, carbazate or the like. Repetition of the two step cycle of acylation and displacement gives the desired oligomers. The efficient synthesis of a wide variety of oligomeric NSGs using automated synthesis technology of the present method makes these oligomers attractive candidates for the generation and rapid screening of diverse peptidomimetic libraries. The oligomers of the invention, such as N-substituted glycines (i.e. poly NSGs) disclosed here provide a new class of peptide-like compounds not found in nature, but which are synthetically accessible and have been shown to possess significant biological activity and proteolytic stability. Combinatorial libraries of cyclic compounds are disclosed wherein the cyclic compounds are comprised of at least one ring structure derived from cyclization of a peptoid backbone. The diversity of product compounds is generated by the sequential addition of substituted submonomers. The combinatorial library includes 10 or more, preferably 100 or more, and more preferably 1,000 or more distinct and different compounds. The library includes each of the product compounds in retrievable and analyzable amounts and preferably includes at least one biologically active compound. Methods of synthesizing the combinatorial libraries and assay devices produced using the libraries are disclosed as is methodology for screening for and obtaining biologically active cyclic organic compounds.

专利号:US-8691979-B2
优先权日:2009-05-12
标题 :Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants
发明人：LARCH CHRISTOPHER PAUL; STOREY JOHN MERVYN DAVID; WILLIAMSON CRAIG; MARSHALL COLIN; KEMP STEVEN JOHN
权利人:LARCH CHRISTOPHER PAUL; STOREY JOHN MERVYN DAVID; WILLIAMSON CRAIG; MARSHALL COLIN; KEMP STEVEN JOHN; WISTA LAB LTD
摘要:Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compoundsâ€?) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

专利号:US-12071388-B2
优先权日:2020-12-24
标 题:Full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds
发明人：YUAN QILIANG; MIAO YONGYI; SHI YONGGEN; ZHANG YIQIANG; CHEN YINHAO; WANG CHAO
权利人:FUJIAN ZHONGXIN FLUORIDE MATERIAL GAOBAO TECH CO LTD; ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD
摘要:A full continuous flow synthesis process of fluorine-containing aromatic hydrocarbon compounds. Aromatic amine and hydrogen fluoride are respectively pumped into thermostats A and B, then flow into micro-channel reactor C for salt forming reaction whose temperature is kept constant; sulfuric acid solution of nitrosylsulfuric acid is pumped into thermostat D; after keeping the temperature constant, the sulfuric acid solution of nitrosylsulfuric acid and salt forming product flowing out from the micro-channel reactor C flow into micro-channel reactor E for diazotization reaction; the obtained product flows into micro-channel reactor F for thermal decomposition reaction, is cooled in cooler G, then enters three-phase separator H for continuous separation, fluorine-containing aromatic hydrocarbon crude product is subjected to continuous alkaline washing, drying and rectification to obtain fluorine-containing aromatic hydrocarbon finished product, and mixture of hydrofluoric acid and sulfuric acid is continuously distilled to obtain hydrogen fluoride and sulfuric acid.

专利号:US-7790881-B2
优先权日:2004-09-23
标 题:Methods of chemical synthesis and purification of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
发明人：STOREY JOHN MERVYN DAVID; SINCLAIR JAMES PETER; MARSHALL COLIN; TAN HAN WAN
权利人:WISTA LAB LTD
摘要:This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compoundsâ€?) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases. Wherein: each of R 1 and R 9 is independently selected from: —H; C 1-4 alkenyl; and halogenated C 1-4 alkyl; each of R 3NA and R 3NB is independently selected from: C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 4-1 alkyl; each of R 7NA and R 7NB is independently selected from: C 1-4 alkyl; C 2-4 alkenyl; and halogenated C 1-4 alkyl; and X is one or more anionic counter ions to achieve electrical neutrality.

专利号:US-6750335-B2
优先权日:1999-10-29
标 题 :Nucleoside derivatives with photolabile protective groups
发明人：PFLEIDERER WOLFGANG; BUEHLER SIGRID; GIEGRICH HEINER
权利人:NIGU CHEMIE GMBH
摘要:The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I) n wherein n R 1 is H, F, Cl, Br, I, or NO 2 ; R 2 is H or CN, provided that R 1 and R 2 are not simultaneously H; R 3 is H, 1-4 C alkyl, or phenyl; R 4 is H or a conventional functional group for the synthesis of oligonuleotides; R 5 is H, OH, halogen or XR 6 , where X=O or S, and R 6 is a conventional nucleotide protecting group; and B is adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl or 5-amino-4-imidazolcarboxamid-3-yl, where, if B is adenine, cytosine or guanine the primary amine functionality, optionally, carries a permanent protecting group. Furthermore, these derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.