CAS: 6384-08-3; 1-Methyl L-Glutamate

相似化合物

5672-83-3 72086-72-7 145038-49-9

上下游产品

CAS号4124-76-9 benzyl N-(2,6-d... | CAS号5672-83-3 |N|-苄氧羰基-L-谷氨酸甲酯 | CAS号5493-38-9 methyl 1-benzoy... | CAS号67-56-1 甲醇 | CAS号56-86-0 L-谷氨酸 | CAS号145038-49-9 Fm°C-Glu-OMe | CAS号56-86-0 L-谷氨酸

Z-L-Gluome置于乙二胺四乙酸,苯甲基磺酰氟,水体系中,用 Aq. Phosphate Buffer 作为反应溶剂,化学反应生成 L-谷氨酸 1-甲酯
参考文献:微生物对映选择性去除n-苄氧羰基氨基保护基.
标题:微生物对映选择性去除n-苄氧羰基氨基保护基.
摘要:为了使n-碳苯甲氧基-1-氨基酸(cbz-Aa)和相关化合物脱保护,通过以cbz-1-Glu作为唯一氮源的富集培养从土壤中选择了一系列微生物.两种节杆菌属的冻干全细胞制剂.在cbz-Glu或cbz-Gly上生长的菌株显示出高裂解活性.已经优化了水解条件,并且获得了几种cbz-Dl-氨基酸的定量对映选择性脱保护,以及几种合成氨基化合物的n-氨基甲酸酯衍生物的脱保护.该方法的应用描述了以高收率和高光学纯度制备cbz-D-烯丙基甘氨酸和1-烯丙基甘氨酸的方法.
DOI:10.1016/j.Molcatb.2012.03.005

专利信息

专利号:US-4504415-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1 and desacetyl thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; STUDER ROLF; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin alpha 1 and desacetyl thymosin alpha 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

专利号:US-4517119-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; LERGIER WILLIAM; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.

专利号:WO-9600391-A1
优先权日:1994-06-23
标题:Methods for the synthesis of diketopiperazines
发明人：CAMPBELL DAVID; GALLOP MARK A; GORDON ERIC M; LOOK GARY C; PATEL DINESH; SZARDENINGS ANNA KATRIN
权利人:AFFYMAX TECH NV; CAMPBELL DAVID; GALLOP MARK A; GORDON ERIC M; LOOK GARY C; PATEL DINESH; SZARDENINGS ANNA KATRIN
摘要:Libraries of diverse diketopiperazines bound to a support and methods for synthesizing diketopiperazines on a solid support are described. These libraries have utility in the area of drug design as they can be screened against biological substances to identify compounds which have desirable biological activity.

专利号:US-5780579-A
优先权日:1993-08-10
标题:Method for the preparation of polyamino acids
发明人：SOULA GERARD; GROSSELIN JEAN-MICHEL; JORDA RAFAEEL; CASTAN CATHERINE
权利人:FLAMEL TECH SA
摘要:PCT No. PCT/FR94/00992 Sec. 371 Date Mar. 28, 1996 Sec. 102(e) Date Mar. 28, 1996 PCT Filed Aug. 9, 1994 PCT Pub. No. WO95/04772 PCT Pub. Date Feb. 16, 1995The present invention relates to a method for the preparation of polyamino acids, with controlled molecular weights, by polymerization of N-carboxyanhydrides (NCAs) of at least one amino acid, using at least one initiator of the strong base type and in liquid medium, characterized in that it consists in including, in the liquid reaction medium, given amounts of water and/or of alcohol. Application: synthesis of polyamino acids with mechanical and rheological characteristics adapted to applications as biomaterials.

专利号:US-6291673-B1
优先权日:1997-10-17
标题:Folic acid derivatives
发明人：FUCHS PHILIP L; LUO JIN; LANTRIP DOUGLAS A
权利人:PURDUE RESEARCH FOUNDATION
摘要:Novel folic acid derivatives and their use in preparation of γ-esters of folic acid via a pteroyl azide intermediate are described. Folic acid γ-esters are useful intermediates in the synthesis of folic acid conjugates capable of binding folate receptors in vitro and in vivo.

专利号:NO-176520-B
优先权日:1988-01-06
标 题:Method of synthesis of a copolymer of two is as well as agent for covering of skin ulcers