CAS: 63897-12-1; 2,4-Dichloro-6-Methyl-3-Nitropyridine

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CAS号4966-90-9 4-羟基-6-甲基-3-硝基-2-吡啶醇 | CAS号675-10-5 6-甲基-4-羟基-2-吡喃酮 | CAS号3749-51-7 2,4-二羟基-6-甲基吡啶 | CAS号10025-87-3 三氯氧磷 | CAS号134991-79-0 6-甲基-2,4-二(甲硫基)... | CAS号134992-24-8 6-甲基-2,4-二(甲硫基)... | CAS号179056-94-1 2-氯-4-甲氧基-6-甲基-... | CAS号179056-98-5 2,4-二氯-6-甲基吡啶-3-胺 | CAS号754989-43-0 6-methyl-3-nitr... | CAS号870135-16-3 2-氯-N4,6-二甲基-3,... | CAS号870135-17-4 4-氯-1,6-二甲基-1H-... | CAS号870135-18-5 2-溴-4-氯-1,6-二甲基...

4-羟基-6-甲基-2-吡喃酮置于ammonium Hydroxide,硝酸,三乙胺,Sodium Nitrite,三氯氧磷体系中,用 溶剂黄146 作为反应溶剂,化学反应 7.5H,反应生成 2,4-二氯-6-甲基-3-硝基吡啶
参考文献:4-叠氮基-3-硝基吡啶热环化成呋喃烷†
标题:4-叠氮基-3-硝基吡啶热环化成呋喃烷†
摘要:在硝化和氯化后从4-羟基-2-吡啶酮1和8中获得的4-氯-3-硝基-2-吡啶3和10与叠氮化钠一起得到4-叠氮基3-硝基吡啶4和11,在热解为呋喃烷6和12.用三苯基膦将呋喃喃6脱氧,得到呋喃山7.通过差示扫描量热法(dsc)研究了叠氮化物4的热分解条件和6至7的脱氧反应.
DOI:10.1002/jhet.5570370537

专利信息

专利号:EP-0609960-B1
优先权日:1989-09-15
标 题 :New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase
发明人：MCCARTHY PETER A; HAMANAKA ERNEST S; WALKER FREDERICK J; CHANG GEORGE; TRUONG THIEN
权利人:PFIZER
摘要:Compounds of the formula the pharmaceutically acceptable salts thereof, wherein Q and R<1> are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-5656634-A
优先权日:1991-03-21
标题 :N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
发明人：CHANG GEORGE; HAMANAKA ERNEST S; MCCARTHY PETER A; TRUONG THIEN V; WALKER FREDERICK J
权利人:PFIZER
摘要:Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R 1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.

专利号:US-7459552-B2
优先权日:2003-05-28
标 题:Method for producing cyclic diamine derivative or salt thereof
发明人：SHIBUYA KIMIYUKI; OHGIYA TADAAKI; MIURA TORU
权利人:KOWA CO
摘要:The present invention is directed to a method for producing a cyclic diamine compound (3) or a salt thereof through the following scheme: n n(wherein Ar represents a phenyl group, a pyridyl group, or a pyrimidinyl group, any of which may have a substituent; X represents NH, S, or O; ring A represents a benzene ring or a pyridine ring, which may have a substituent; 1 represents an integer of 1 or 2; m represents an integer of 1 or 2; and n represents an integer of 1 to 6). The method enables synthesis of a cyclic diamine compound (3) or a salt thereof, which serves as an ACAT inhibitor, in an industrially useful manner.

专利号:US-5596001-A
优先权日:1993-10-25
标题 :4-aryl-3-(heteroarylureido)quinoline derivatves
发明人：HAMANAKA ERNEST S
权利人:PFIZER
摘要:Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and natiatherosclerosis agents.

专利号:NO-333799-B1
优先权日:2003-07-07
标 题:Intermediate for the synthesis of 2,4-bis (trifluoroethoxy) pyridine compounds