CAS: 6670-13-9; 4,5-Diphenyloxazole-2(3H)-Thione

该化合物是一种环环的杂循环化合物,其特点是存在一种含有氮和氧原子的五人环;该化合物的特点是与氧气结构相连的两个联苯组,其性能有其芳香特性,并有可能影响其活性和溶解性;硫磷功能组,即一个氯酮的硫磺类比,具有独特的化学特性,包括能够参与各种化学反应,如核分裂术攻击和与金属离子的协调;该化合物通常用于有机合成,由于其形成稳定的复合体的能力,可用作协调化学的离子体;其物理特性,如熔点和溶性,可因使用的具体条件和溶剂而不同.

英文名称4,5-Diphenyloxazole-2(3H)-Thione
中文名称4,5-二苯基噁唑-2(3H)-硫酮
IUPAC名称4,5-diphenyloxazole-2(3H)-thione
其它别名4,5-二苯基-2-巯基-4-噁唑啉; 4,5-Diphenyl-4-Oxazoline-2-Thione
CAS编号6670-13-9
MFCD编号:MFCD00022414
EINECS号:229-707-4
分子式:C15H11NOS
分子量:253.32
产品CID: 1648380
产品分类有机原料→分子砌块→芳杂环类化合物→噁唑类化合物

相似结构搜索
产品信息参考
InChIKey: NYQSTRUSYDZNHC-UHFFFAOYSA-N
InChI=1S/C15H11NOS/c18-15-16-13(11-7-3-1-4-8-11)14(17-15)12-9-5-2-6-10-12/h1-10H,(H,16,18)…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数2.0

相似化合物

4675-18-7 14224-99-8 5014-83-5

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(吸入)
急性毒性类别4(经皮)
急性毒性类别4(经口)
皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H332 |吸入有害.
H312 |皮肤接触有害.
H302 |吞咽有害.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501
危险等级IRRITANT
UN编号UN 3335
危险品标志Xn
安全声明36
危险类别码20/21/22
WGK Germany3

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

4,5-Diphenyloxazol-2-One置于tetraphosphorus Decasulfide,Xylene体系中,化学反应生成 4,5-二苯基-4噁唑啉
参考文献:Gompper,Chemische Berichte,1956,Vol. 89,P. 1762,1767
标题:Gompper,Chemische Berichte,1956,Vol. 89,P. 1762,1767

海关参考信息

2902200000-苯
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详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2003187027-A1
优先权日:2001-05-09
标题:Dioxanes and uses thereof
发明人：SCHREIBER STUART L; STERNSON SCOTT M; WONG JASON C; GROZINGER CHRISTINA M
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): n n n and pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 , R 3 , n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (1) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p.

专利号:US-8178579-B2
优先权日:2001-05-09
标题:Dioxanes and uses thereof
发明人：SCHREIBER STUART L; STERNSON SCOTT M; WONG JASON C; GROZINGER CHRISTINA M; HAGGARTY STEPHEN J; KOELLER KATHRYN M
权利人:SCHREIBER STUART L; STERNSON SCOTT M; WONG JASON C; GROZINGER CHRISTINA M; HAGGARTY STEPHEN J; KOELLER KATHRYN M; HARVARD COLLEGE
摘要:In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): n nand pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 , R 3 , n, X and Y are as defined herein. The present invention also provides pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier. The present invention further provides compounds capable of inhibiting histone deacetylatase activity and methods for treating disorders regulated by histone deacetylase activity (e.g., cancer and protozoal infections) comprising administering a therapeutically effective amount of a compound of formula (I) to a subject in need thereof. The present invention additionally provides methods for modulating the glucose-sensitive subset of genes downstream of Ure2p. The present invention also provides methods for preparing compounds of the invention.