4-丙基甲苯置于溴,碘,硝酸体系中,化学反应生成 3-溴-4-甲基苯甲酸 参考文献:Hydrogen Transfer. Iii.1 Reaction Of P-Ethyltoluene And P-Propyltoluene With Methylcyclohexene. Synthesis Of Diarylalkanes 标题:Hydrogen Transfer. Iii.1 Reaction Of P-Ethyltoluene And P-Propyltoluene With Methylcyclohexene. Synthesis Of Diarylalkanes 摘要: DOI:10.1021/ja01178A080
专利号:WO-2013117440-A1 优先权日:2012-02-09 标 题 :Synthesis of water-soluble phosphine oxides by pd/c-catalyzed p-c coupling in water 发明人:RANOCCHIARI MARCO; RUMMELT STEPHAN; VAN BOKHOVEN JEROEN A 权利人:SCHERRER INST PAUL 摘要:Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times, microwave irradiation, and high substrate scope make this method general and excellent for lab- and large-scale synthesis without the need to use organic solvents for neither reaction nor workup.
专利号:US-6664282-B2 优先权日:1999-09-17 标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds 发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TORREY PINES INST 摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.
专利号:US-9994550-B2 优先权日:2014-01-07 标题 :Heterocyclic modulators of lipid synthesis for use against cancer and viral infections 发明人:WAGMAN ALLAN S; JOHNSON RUSSELL J; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREG; OHOL-GUPTA YAMINI; HEUER TIMOTHY; O'FARRELL MARIE 权利人:3 V BIOSCIENCES INC 摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds.
专利号:US-2024400552-A1 优先权日:2016-11-11 标题 :Heterocyclic modulators of lipid synthesis 发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S 权利人:SAGIMET BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
专利号:US-11622968-B2 优先权日:2011-03-08 标 题:Heterocyclic modulators of lipid synthesis 发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S 权利人:SAGIMET BIOSCIENCES INC 摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).
专利号:US-5856107-A 优先权日:1997-02-04 标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein 发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A 权利人:TREGA BIOSCIENCES INC 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.
[参考文献]: Baihua Xu, Et Al. O-Spiro C-Aryl Glucosides As Novel Sodium-Dependent Glucose Co-Transporter 2 (Sglt2) Inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5632-5. [参考文献]: Richard M Angell, Et Al. Biphenyl Amide P38 Kinase Inhibitors 2: Optimisation And Sar. Bioorg Med Chem Lett. 2008 Jan 1;18(1):324-8.
合成参考文献
摘要:D. Peltier, Bull. Soc. Chim. Fr. 1958, 994. Values also quoted from D. Peltier, Thesis, Rennes, (1956); C. R. Acad. Sci., Ser. C 243, 2086 (1956); 244, 2811 (1957); 245, 436 (1957).