CAS: 7697-26-9; 3-Bromo-4-Methylbenzoic Acid

该化合物是一种卤化芳烃式的碳盒酸,其分子式为C8H7BRO2,该化合物是有机合成的多用途中间体,特别是在制药和农用化学应用方面.三处的溴替代物和四处的甲基组增强了其反应性,使其对进一步功能化(如交叉反应或核循环生物替代物)具有价值.其晶体固体形式确保了在标准条件下的稳定性和方便处理.该化合物的清晰结构和纯度使其适合精确的合成路线,有助于其在研究和工业过程中的效用.

结构式图片

欧盟法规

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上下游产品

CAS号64-17-5 乙醇 | CAS号2458-12-0 3-氨基-4-甲基苯甲酸 | CAS号99-94-5 对甲基苯甲酸 | CAS号553-94-6 2,5-二甲基溴苯 | CAS号1074-55-1 4-丙基甲苯 | CAS号5337-93-9 对甲基苯丙酮 | CAS号106-42-3 对二甲苯 | CAS号94-08-6 对甲基苯甲酸乙酯 | CAS号112449-73-7 1-(3-bromo-4-me... | CAS号3556-83-0 3-甲氧基-4-甲基苯甲酸甲 | CAS号42872-74-2 3-溴-4-甲基苯甲腈 | CAS号36276-24-1 3-溴-4-甲基苯甲醛 | CAS号147962-81-0 3-溴-4-甲基苯甲酸乙酯 | CAS号21900-33-4 3-溴-4-甲基 苯甲酰氯 | CAS号321879-67-8 3-bromo-4-methy... | CAS号18484-04-3 2-[(4-methylphe... | CAS号589-18-4 4-甲基苄醇 | CAS号79669-49-1 2-甲基-5-溴苯甲酸 | CAS号66417-30-9 3-溴-4-甲基三氟甲苯

合成工艺路线路线简述

    4-丙基甲苯置于溴,碘,硝酸体系中,化学反应生成 3-溴-4-甲基苯甲酸
    参考文献:Hydrogen Transfer. Iii.1 Reaction Of P-Ethyltoluene And P-Propyltoluene With Methylcyclohexene. Synthesis Of Diarylalkanes
    标题:Hydrogen Transfer. Iii.1 Reaction Of P-Ethyltoluene And P-Propyltoluene With Methylcyclohexene. Synthesis Of Diarylalkanes
    摘要:
    DOI:10.1021/ja01178A080

    海关参考信息

    专利信息


    专利号:WO-2013117440-A1
    优先权日:2012-02-09
    标 题 :Synthesis of water-soluble phosphine oxides by pd/c-catalyzed p-c coupling in water
    发明人:RANOCCHIARI MARCO; RUMMELT STEPHAN; VAN BOKHOVEN JEROEN A
    权利人:SCHERRER INST PAUL
    摘要:Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times, microwave irradiation, and high substrate scope make this method general and excellent for lab- and large-scale synthesis without the need to use organic solvents for neither reaction nor workup.

    专利号:US-6664282-B2
    优先权日:1999-09-17
    标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
    发明人:ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
    权利人:TORREY PINES INST
    摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

    专利号:US-9994550-B2
    优先权日:2014-01-07
    标题 :Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
    发明人:WAGMAN ALLAN S; JOHNSON RUSSELL J; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREG; OHOL-GUPTA YAMINI; HEUER TIMOTHY; O'FARRELL MARIE
    权利人:3 V BIOSCIENCES INC
    摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds.

    专利号:US-2024400552-A1
    优先权日:2016-11-11
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11622968-B2
    优先权日:2011-03-08
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-5856107-A
    优先权日:1997-02-04
    标 题 :Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
    发明人:OSTRESH JOHN M; HOUGHTEN RICHARD A
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene compounds. The present invention further provides methods of preparing the libraries and the individual compounds made by the combinatorial synthesis.
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    主要参考文献

    [参考文献]: Baihua Xu, Et Al. O-Spiro C-Aryl Glucosides As Novel Sodium-Dependent Glucose Co-Transporter 2 (Sglt2) Inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5632-5.
    [参考文献]: Richard M Angell, Et Al. Biphenyl Amide P38 Kinase Inhibitors 2: Optimisation And Sar. Bioorg Med Chem Lett. 2008 Jan 1;18(1):324-8.

    合成参考文献


    摘要:D. Peltier, Bull. Soc. Chim. Fr. 1958, 994. Values also quoted from D. Peltier, Thesis, Rennes, (1956); C. R. Acad. Sci., Ser. C 243, 2086 (1956); 244, 2811 (1957); 245, 436 (1957).
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