CAS: 86060-81-3; Fmoc-Cys(Acm)-Oh

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9-芴甲基-N-琥珀酰亚胺基碳酸酯置于盐酸,Sodium Carbonate,三氟乙酸,锌体系中,用 二氯甲烷,水,乙酸乙酯,丙酮 作为反应溶剂,化学反应 1.0H,反应生成 芴甲氧羰基-S-乙酰氨甲基-L-半胱氨酸
参考文献:Flemer,Stevenson,Protein And Peptide Letters,2014,Vol. 21,# 12,P. 1257-1264
标题:Flemer,Stevenson,Protein And Peptide Letters,2014,Vol. 21,# 12,P. 1257-1264

专利信息

专利号:US-2023242581-A1
优先权日:2020-06-17
标题:Synthesis of a guanylate cyclase agonist by fragments based approach
发明人：SAMBASIVAM GANESH; KASTURCHAND GODHA ATUL; VENKATA BHAGYARAJ ARETI; ANNADURAI SATHYA; VEERANJANEYULU AVULA; VASANTRAO GADAKH AMOL; S JADHAV DIPAK
权利人:ANTHEM BIOSCIENCES PRIVATE LTD
摘要:The present invention provides a process for the synthesis of Plecanatide, a guanylate cyclase agonist. The process involves convergent synthesis with compounds, i.e., fragment of peptides followed by cyclization. The method provides high yield of Plecanatide with less impurities.

专利号:US-9475837-B2
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides
发明人：HURLEY FIONN; WEGNER KATARZYNA; FOLEY PATRICK
权利人:IPSEN MFG IRELAND LTD
摘要:The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.

专利号:US-2004054161-A1
优先权日:2002-09-13
标题 :Stepwise solid-phase synthesis of peptide-oligonucleotide conjugates and supports therefor
发明人：ANTOPOLSKII MAXIM; AZHAYEVA ELENA; AZHAYEV ALEX
权利人:GLEN RES CORP
摘要:A support for peptide-oligonucleotide conjugate synthesis includes an article of manufacture according to the formula: n n n wherein: (a) substitutent A includes a polymeric base material and/or a silica base material; (b) one of substituents B and C includes an NHFmoc-containing group and/or a peptide-containing group; (c) one of substituents B and C includes an NHBoc-containing group, an O-DMTr-containing group, and/or an oligonucleotide-containing group; and (d) each X independently represents â•?O, S, and/or NH. Suitable supports include those according to the formula: n n n wherein substituents A, B, and C have the meanings described above. When used to synthesize a peptide-oligonucleotide conjugate, the resulting conjugate may have the formula: n n n wherein substituent B includes a peptide and substituent C includes an oligonucleotide.

专利号:US-12162957-B2
优先权日:2018-12-08
标 题:Process for the preparation of plecanatide
发明人：ADAK SANDIP; BONTE MANOJ; KULKARNI CHANDRAKANT; SWAMY VEERANARAYANA; JOGDAND NIVRUTTI; GADGIL HIMANSHU
权利人:ENZENE BIOSCIENCES LTD
摘要:A process for the preparation of plecanatide. Specifically, an improved process for preparation of plecanatide using a non-linear solid phase peptide synthesis. In particular, the process for preparation of plecanatide involves solid phase synthesis of peptide fragments of five amino acid units using 2-chlorotrityl chloride (2-ClTrt) resin and eleven amino acid unit using Wang resin.

专利号:US-12441760-B2
优先权日:2013-08-29
标 题 :Amino diacids containing peptide modifiers
发明人：BARLOS KLEOMENIS; GATOS DIMITRIOS; BARLOS KOSTAS K; VASILEIOU ZOI
权利人:CHEMICAL & BIOPHARMACEUTICAL LABORATORIES OF PATRAS S A
摘要:The present invention relates to peptide modifier compounds of Formula (1), or a salt thereof, wherein: a is an integer from 1 to 10, more preferably from 1 to 3; b is an integer from 0 to 7; Z is a terminal group and Y is a bivalent group. Further aspects of the invention relate to intermediates in the preparation of compounds of Formula (1), and the use of compounds of Formula (1) in the synthesis of peptide derivatives.

专利号:WO-2024143052-A1
优先权日:2022-12-26
标题 :Peptide synthesis method
发明人：HOJO KEIKO; TSUDA YUKO
权利人:KOBE GAKUIN EDUCATIONAL FOUND
摘要:To provide a peptide synthesis method that is simpler, more efficient, and/or more environmentally friendly.　Provided is a peptide synthesis method that includes bringing a mixed dispersion of a protected amino acid for peptide synthesis, a base, a water-soluble condensing agent, and an aqueous solvent into contact with an amino acid and/or a peptide and inducing a condensation reaction of the protected amino acid for peptide synthesis and the amino acid and/or peptide.