CAS: 99548-55-7; Methyl 4-Bromo-2-Methylbenzoate

上下游产品

CAS号68837-59-2 4-溴-2-甲基苯甲酸 | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号74-88-4 碘甲烷 | CAS号67-56-1 甲醇 | CAS号67832-11-5 4-溴-2-甲基苯甲腈 | CAS号21900-45-8 4-溴-2-甲基苯甲酰氯 | CAS号77-78-1 硫酸二甲酯 | CAS号35598-05-1 4-甲氧基-2-甲基苯甲酸甲酯 | CAS号1975-53-7 4-氰基-2-甲基苯甲酸 | CAS号215800-05-8 2-(4-溴-2-甲氧基苯基)乙腈 | CAS号24078-12-4 4-溴-2-甲基苯甲醛 | CAS号868066-91-5 5-溴-2-甲基异二氢吲哚-1-酮 | CAS号552330-86-6 5-溴-1-异吲哚酮 | CAS号103261-67-2 4-氰基-2-甲基苯甲酸甲酯 | CAS号17100-58-2 (4-溴-2-甲基苯基)甲醇 | CAS号156001-49-9 4-溴-1-(溴甲基)-2-甲基苯 | CAS号165111-46-6 2-溴甲基-4-氰基苯甲酸甲酯

4-溴-2-甲基苯腈置于硫酸,溶剂黄146,N,N-二异丙基乙胺体系中,用 水,乙腈 作为反应溶剂,化学反应 24.5H,反应生成 4-溴-2-甲基苯甲酸甲酯
参考文献:Benzohydroxamic Acids As Potent And Selective Anti-Hcv Agents
标题:Benzohydroxamic Acids As Potent And Selective Anti-Hcv Agents
摘要:A Diverse Collection Of 40 Derivatives Of Benzohydroxamic Acid (Bhas) Of Various Structural Groups Were Synthesized And Tested Against Hepatitis C Virus (Hcv) In Full-Genome Replicon Assay. Some Of These Compounds Demonstrated An Exceptional Activity,Suppressing Viral Replication At Sub-Micromolar Concentrations. The Compounds Were Inactive Against Key Viral Enzymes Ns3,And Ns5B In Vitro Assays,Suggesting Host Cell Inhibition Target(S). The Testing Results Were Consistent With Metal Coordination By The Bhas Hydroxamic Group In Complex With A Target(S). Remarkably,This Class Of Compounds Did Not Suppress Poliomyelitis Virus (Pv) Propagation In Rd Cells Indicating A Specific Antiviral Activity Of Bhas Against Hcv. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2013.08.081

专利信息

专利号:US-2024400552-A1
优先权日:2016-11-11
标题 :Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-11622968-B2
优先权日:2011-03-08
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-10226449-B2
优先权日:2013-12-20
标 题:Heterocyclic modulators of lipid synthesis and combinations thereof
发明人：HEUER TIMOTHY SEAN; OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by dysregulation of a fatty acid synthase pathway by the administration of such compounds and combinations of such compounds and other therapeutic agents.

专利号:US-11034690-B2
优先权日:2016-11-11
标 题:Heterocyclic modulators of lipid synthesis
发明人：BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
权利人:SAGIMET BIOSCIENCES INC; SAGINIET BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

专利号:US-9428502-B2
优先权日:2012-07-03
标题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; WAGMAN ALLAN S
权利人:3-V BIOSCIENCES INC
摘要:Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.

专利号:US-9809591-B2
优先权日:2011-03-08
标题 :Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W
权利人:3-V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.