专利号:US-11306041-B2 优先权日:2017-03-30 标 题:Catalytic synthesis of super linear alkenyl arenes using rhodium catalysts 发明人:SCHINSKI WILLIAM; GOLDMAN ALAN; GUNNOE THOMAS B; WEBSTER-GARDINER MICHAEL S; SCHWARTZ NICHOLE 权利人:UNIV VIRGINIA PATENT FOUNDATION 摘要:Catalytic methods for synthesis of super linear alkenyl arenes and alkyl arenes are provided. The methods are capable of synthesizing super linear alkyl and alkenyl arenes from simple arene and olefin starting materials and with high selectivity for linear coupling. Methods are also provided for making a 2,6-dimethylnapthalene (DMN) or 2,6-methylethylnapthalene (MEN).
专利号:US-6861531-B2 优先权日:2002-03-27 标 题:Synthesis of 2,6-dicarbonylpyridines 发明人:GATELY DANIEL A 权利人:BOULDER SCIENT CO 摘要:Synthesis of 2,6-dicarbonylpyridines in solution in a hydrocarbon medium is described. The solutions of 2,6-dicarbonylpyridines may be used directly in further syntheses.
专利号:WO-2023151188-A1 优先权日:2022-02-08 标题 :Green synthesis method of antiviral drug intermediate 发明人:XIA BIN; WANG JIAMING; ZHANG XIANSHU; CAI LINGLI; WANG ZIKUN; CAO MING; YANG SHAOBO; GAO QIANG; ZHENG BAOFU 权利人:SHANGHAI HAOYUAN CHEMEXPRESS CO LTD 摘要:The present application provides a green synthesis method of an antiviral drug intermediate. The method comprises: in the presence of a catalyst, adding zinc powder into a compound as represented by a formula II and performing a cyclization reaction with dihaloalkane to generate a compound as represented by a formula I, zinc halide being not required to be added to the cyclization reaction, wherein R1 is selected from H or an amino-protecting group, and R2 is selected from substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C6-C14 aryl or substituted or unsubstituted C7-C14 aralkyl; R3 and R4 are each independently selected from hydrogen, substituted or unsubstituted C1-C10 alkyl, and R3 and R4 can be connected to form a fatty ring containing 3-10 carbon atoms. The synthesis method is short in steps, dangerous and expensive materials are not used, a reaction conversion rate is high, reaction time is short, and operation is easy and convenient. Production costs and post-treatment costs are reduced, and a cost advantage is obvious. The method can be widely used for preparing antiviral drugs of nirmatrelvir, boceprevir or narlaprevir, and has good market prospects.
专利号:US-2003187271-A1 优先权日:2002-03-27 标题 :Synthesis of 2, 6-dicarbonylpyridines
专利号:US-6482949-B1 优先权日:1999-05-28 标题 :Colormetric sensor compositions and methods 发明人:SESSLER JONATHAN; ANDRIOLETTI BRUNO; TRY ANDREW CARL; BLACK CHRISTOPHER 摘要:The present invention provides novel compounds exemplified by pyrrolic nitrogens used as anion and neutral species recognition elements with an aromatic core as a signal group. Described are methods for the synthesis of various pyrrole aryl compounds as well as various applications for these compounds. Methods of use include the binding and detection of specific analytes in a mixture and, in some examples, the separation of the analyte from the mixture. Additional methods of use include the transport of therapeutic agents and the sensing of components, degradants, and impurities in foodstuffs.
专利号:WO-03082824-A1 优先权日:2002-03-27 标 题 :Synthesis of 2,6-dicarbonylpyridines
摘要:Schafer, E. W., Jr., and W. A. Bowles Jr. 1985. Acute oral toxicity and repellency of 933 chemicals to house and deer mice. Archives of Environmental Contamination and Toxicology 14:111-129. 参考文献:10.1107/s1600536810026851 摘要:Shi G, Ma L, Deng H. 2-[1-(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)-1H-benzimidazol-2-yl]benzoic acid methanol solvate. Acta Crystallogr Sect E Struct Rep Online. 2010 Jul 17;66(Pt 8):o2034. 参考文献:10.1021/ic2006869 摘要:Vicente J, Arcas A, Juliá-Hernández F, Bautista D. Synthesis, isolation, and characterization of an organometallic triiodopalladium(IV) complex. Quantitative and regioselective synthesis of two C-I reductive elimination products. Inorg Chem. 2011 Jun 20;50(12):5339–41. doi: 10.1021/ic2006869.