CAS: 153502-27-3; O-(2-(Trimethylsilyl)Ethyl)Hydroxylamine Hydrochloride
该化合物是一种化学化合物,其特点是其独特的结构,包括三甲基硅基化合物,乙基链和氢氧基胺功能组;该化合物通常以盐酸盐形式出现,在极溶剂中溶解性增强;该化合物经常用于有机合成,特别是在有机硅化学领域,该化合物是各种转化的试剂,包括保护氨和将硅功能引入有机分子;氢氧胺组的存在允许在形成氧化物和减少碳基化合物中潜在应用;此外,三甲基硅基化合物组可以提供稳定性,增强化合物的挥发性,使其在气色学中有用;安全数据表明,与许多有机硅化合物一样,应谨慎处理该化合物,因为它可能构成风险,如接触时的刺激或毒性.在与该物质打交道时,适当的实验室做法和安全议定书至关重要.
- 英文名称O-(2-(Trimethylsilyl)Ethyl)Hydroxylamine Hydrochloride
- 中文名称O-(2-三甲基硅基乙基)羟胺盐酸盐
- IUPAC名称O-(2-(trimethylsilyl)ethyl)hydroxylamine hydrochloride
- 其它别名Hydroxylamine,O-[2-(Trimethylsilyl)Ethyl]-, Hydrochloride (1:1); [2-(Aminooxy)Ethyl]Trimethylsilane Hydrochloride; O-(2-Trimethylsilylethyl)Hydroxylamine Hydrochloride; Trimethylsilylethylhydroxylaminehydrochloride; O-(2-Trimethylsilylethyl)Hydroxylaminehcl90+%; O-(2-Trimethylsilylethyl)Hydroxylaminehydrochloride90+%; 0-(2-Trimethylsilylethyl)Hydroxylamine-Hydrochloride; O-(2-(Trimethylsilyl)Ethyl)Hydroxylamine Hcl
- CAS编号153502-27-3
- MFCD编号:MFCD01321199
- 分子式:C5H16ClNOSi
- 分子量:169.73
- 产品CID: 753958
- 产品分类化学试剂 → 有机试剂 → 羟胺
合成工艺路线路线简述
专利信息
专利号:US-6458822-B2
优先权日:2000-03-13
标题 :2-oxo-imidazolidine-4-carboxylic acid hydroxamide compounds that inhibit matrix metalloproteinases
发明人：ROBINSON RALPH P; LAIRD ELLEN R
权利人:PFIZER
摘要:The present invention relates to a compound of the formula n wherein R 1 , R 2 , R 3 and R 4 are as defined above, and pharmaceutically acceptable salts and solvates thereof, that are useful, for example, as matrix metalloproteinase inhibitors. The present invention is also directed to pharmaceutical compositions comprising such compounds and methods of treatment for diseases such as osteoarthritis, rheumatoid arthritis, cancer, osteoporosis, tissue ulceration, restinosis, periodontal disease, inflammation, epidermolysis bullosa, scleritis, stroke, Alzheimer's disease, and the like, characterized by inappropriate matrix metalloproteinase activity. Processes for the synthesis of compounds of formula (I) are also disclosed.
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主要参考文献
参考标题:2-Oxo-Imidazolidine-4-Carboxylic Acid Hydroxamide Compounds That Inhibit Matrix Metalloproteinases摘要:The Present Invention Relates To A Compound Of The Formula 1 Wherein R 1 , R 2 , R 3 And R 4 Are As Defined Above, And Pharmaceutically Acceptable Salts And Solvates Thereof, That Are Useful, For Example, As Matrix Metalloproteinase Inhibitors. The Present Invention Is Also Directed To Pharmaceutical Compositions Comprising Such Compounds And Methods Of Treatment For Diseases Such As Osteoarthritis, Rheumatoid Arthritis, Cancer, Osteoporosis, Tissue Ulceration, Restinosis, Periodontal Disease, Inflammation, Epidermolysis Bullosa, Scleritis, Stroke, Alzheimer'S Disease, And The Like, Characterized By Inappropriate Matrix Metalloproteinase Activity. Processes For The Synthesis Of Compounds Of Formula (I) Are Also Disclosed.
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