CAS: 17455-13-9; 1,4,7,10,13,16-Hexaoxacyclooctadecane

上下游产品

CAS号2615-15-8 六乙二醇 | CAS号62796-84-3 1,4,7,10,13,16-... | CAS号86309-77-5 1,4,7,10,13,16-... | CAS号19249-03-7 三乙二醇二对甲苯磺酸酯 | CAS号112-27-6 三甘醇 | CAS号86309-78-6 1,4,7,10,13,16-... | CAS号4792-15-8 五甘醇 | CAS号54129-84-9 O,O-diethyl eth... | CAS号77544-68-4 对甲苯磺酸酯-三聚乙二醇 | CAS号112-60-7 三缩四乙二醇 | CAS号5331-73-7 Ethyl 3-ethoxy-... | CAS号57592-45-7 3-乙氧基-2-丁烯酸乙酯 | CAS号1619-57-4 2,2-二乙基乙酰乙酸乙酯 | CAS号607-97-6 2-乙基乙酰乙酸乙酯 | CAS号14099-01-5 五羰基氯铼(I) | CAS号64145-93-3 [(CO)3Re(μ-Cl)3... | CAS号70069-04-4 2-(羟甲基)-18-冠6-醚 | CAS号1157-84-2 苯甲醛 2,4-二硝基苯基腙 | CAS号14316-14-4 N-(2-羟乙基)-4-甲基苯磺酰胺 | CAS号1677-87-8 Ethanone, 1-phe...

三乙二醇置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃,甲苯 用作溶剂,化学反应 1.5H,反应生成18-冠醚-6
参考文献:将冠内酯还原为冠醚
标题:将冠内酯还原为冠醚
摘要:冠状内酯可以使用氢化铝锂还原为冠状醚.
Doi:10.1039/c39820000248

专利信息

专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:US-11912654-B2
优先权日:2021-09-03
标 题:Process for stereospecific synthesis of vitamin K2 and its novel intermediates
发明人：MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; SHAH ASHWIN; VORA PARIN; MAHALE UMAKANT
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7. The present disclosure further discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

专利号:WO-2023031841-A1
优先权日:2021-09-03
标题:A process for the stereospecific synthesis of vitamin k2 and its intermediates
发明人：MEHTA DILIP; SHASHTRI MAYANK; RAJU BNS; VORA PARIN; MAHALE UMAKANT
权利人:SYNERGIA LIFE SCIENCES PVT LTD
摘要:The present disclosure relates to a novel process for the synthesis of stereospecific compounds of Vitamin K2 group in general and Vitamin K2-7, in particular. It also discloses novel intermediates useful in the synthesis of stereospecific Vitamin K2-7. Compounds of the Vitamin K2 group obtained are crystalline and exhibit well defined melting points.

专利号:US-11434211-B2
优先权日:2020-06-16
标题:Synthesis of 5-nitrotetrazole
发明人：PIERCEY DAVIN GLENN; MANSHIP TIMOTHY D; SMITH DAWSON MICHAEL
权利人:PURDUE RESEARCH FOUNDATION
摘要:This disclosure shows the ability of a readily-available oxidizer to achieve oxidation of 5-amino-1H-tetrazole (5-AT) to 5-nitrotetrazole (5-NT) in high yields in a single pot synthesis. This strategy reduces the synthesis of this important energetic material down to a single step and eliminates highly sensitive diazonium and copper salt primary explosive intermediates. The overall yield of this process is 48-53% and the resultant aqueous solution of product effectively used for the preparation of nitrotetrazole-containing primary explosive DBX-1. Unlike current methods of nitrotetrazole preparation, the novel method is entirely solution-based and prepares a final solution of sodium nitrotetrazolate, never once needing to handle energetic intermediates or products, making it a much safer method of nitrotetrazole preparation.

专利号:US-4592874-A
优先权日:1980-05-14
标 题:Process for the synthesis of alpha-chlorinated chloroformates
发明人：CAGNON GUY C; PITEAU MARC D; SENET JEAN-PIERRE G; OLOFSON ROY A; MARTZ JONATHAN T
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:Process for the synthesis of alpha -chlorinated chloroformates, and new alpha -chlorinated chloroformates. The invention relates to a new process for the manufacture of alpha -chlorinated chloroformates and, to new alpha -chlorinated chloroformates as new industrial products. The process according to the invention consists of a synthesis, by catalytic phosgenation, of alpha -chlorinated chloroformates of the formula: in which: R represents a substituted or unsubstituted hydrocarbon radical and m represents an integer superior or equal to one, this synthesis consisting in reacting phosgene with the aldehyde R-CHO)m, in the presence of a catalyst which is an organic or inorganic substance which is capable in a medium containing an aldehyde of the formula R-CHO)m, phosgene and, possibly, a solvent, of generating a pair of ions one of which is an halogenide anion and the other is a cation which is sufficiently separated from said halogenide anion so as to give to the latter a nucleophilic power enabling it to react with the function(s) aldehyde of the molecule R-CHO)m.

专利号:US-2011245503-A1
优先权日:2008-11-28
标题 :Enantioselective synthesis of asymmetric beta-carboline intermediates
发明人：SANTOS LEONARDO; ESPINOZA MORAGA MARLENE; SHANKARAJAH NAGULA
权利人:UNIV TALCA
摘要:Described herein is a new asymmetric synthesis of imines to obtain β-carboline derivatives useful as key intermediate compounds for the synthesis of phosphodiesterase inhibitors using a new process with palladium or ruthenium hydride and/or nickel boride to reduce chiral intermediates. The use of chloroformate chiral auxiliaries is further described for the reduction and asymmetric hydrogenation of imines to obtain β-carboline derivatives and intermediate compounds used in the preparation thereof.