CAS: 23687-26-5; 6-Aminoisoquinoline

相似化合物

23707-37-1 23687-27-6 23687-25-4

上下游产品

isoquinolin-6-ol 6-nitroisoquinoline 1,2,3,4-tetrahydroisoquinoline ammonium hydroxide N-isoquinolin-6-yl-acetamideN-isoquinolin-6-yl-acetamide 5-bromo-isoquinolin-6-ylamine 5-chloro-6-aminoisoquinoline 6-(4-Toluenesulfonylamino) isoquinoline

6-溴异喹啉置于ammonium Hydroxide,Copper(Ll) Sulfate Pentahydrate体系中,用 水 用作溶剂,化学反应 6.0H,以85%的收率获得6-氨基异喹啉
参考文献:Substituted Isoquinoline Derivative
标题:Substituted Isoquinoline Derivative
摘要:本发明提供了一种作为新型药物剂的异喹啉-6-磺酰胺衍生物.本发明提供了由式(1)表示的异喹啉-6-磺酰胺衍生物,其盐或该衍生物或盐的溶剂:其中x和y分别独立表示直接键,Nh,Ch═ch,O或s;R1和r2分别独立表示氢原子,卤素原子,氰基,烷基或类似物;R3和r4分别独立表示氢原子,烷基或类似物,或r3和r4共同形成烷基或烯基,可以在两个碳原子之间被桥接到任意位置;L,M和n表示1到4的整数.

专利信息

专利号:US-9840468-B1
优先权日:2016-12-30
标 题:Methods for the preparation of 6-aminoisoquinoline
发明人：CHAMBOURNIER GILLES; DELONG MITCHELL A
权利人:AERIE PHARMACEUTICALS INC
摘要:Described are methods for the preparation of 6-aminoisoquinoline, a useful intermediate compound in the synthesis of kinase inhibitors.

专利号:US-10550087-B2
优先权日:2015-11-17
标 题:Process for the preparation of kinase inhibitors and intermediates thereof
发明人：STURDIVANT JILL MARIE; DELONG MITCHELL A; CHAMBOURNIER GILLES; PAMMENT MICHAEL G; FEDIJ VICTOR
权利人:AERIE PHARMACEUTICALS INC
摘要:Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.

专利号:US-9643927-B1
优先权日:2015-11-17
标题:Process for the preparation of kinase inhibitors and intermediates thereof
发明人：STURDIVANT JILL M; DELONG MITCHELL A; CHAMBOURNIER GILLES; PAMMENT MICHAEL G; FEDIJ VICTOR
权利人:AERIE PHARMACEUTICALS INC
摘要:Described are processes for the synthesis of certain compounds, useful for treating diseases, e.g. eye disease, such as glaucoma and ocular hypertension, in a subject.

专利号:US-6797820-B2
优先权日:1999-12-17
标 题:Succinate compounds, compositions and methods of use and preparation
发明人：PATEL DINESH; JACOBS JEFFREY W; JAIN RAKESH; NI ZHI-JIE; YUAN ZHENGYU
权利人:VICURON PHARM INC
摘要:Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

专利号:WO-0144179-A1
优先权日:1999-12-17
标题 :Novel succinate compounds, compositions and methods of use and preparation
发明人：JAIN RAKESH; NI ZHI-JIE; PATEL DINESH V; YUAN ZHENGYU
权利人:VERSICOR INC; JACOBS JEFFREY W; JAIN RAKESH; NI ZHI JIE; PATEL DINESH V; YUAN ZHENGYU
摘要:Novel hydroxamic acid compounds of Formula (I) are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes. The hydroxymates are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as matrix metalloproteinases (MMPs). Methods of synthesis and of use of the compounds are also disclosed.

专利号:IT-201800007398-A1
优先权日:2018-07-20
标题:PROCESS FOR THE SYNTHESIS OF DIMESILATED NETARSUDIL