1,10-癸二醇置于lithium Bromide体系中,用 四氢呋喃,六甲基磷酰三胺 作为反应溶剂,化学反应 4.25H,反应生成 1,10-二溴癸烷 参考文献:A New And Efficient One-Pot Preparation Of Alkyl Halides From Alcohols 标题:A New And Efficient One-Pot Preparation Of Alkyl Halides From Alcohols 摘要:初级醇和2-烯醇通过一步法两步反应转化为相应的卤化物,Yields 高,先转化为中间体三氟乙酸酯,然后与卤化锂进行亲核取代. DOI:10.1055/s-1987-27988
专利号:US-6770436-B1 优先权日:1996-11-14 标题:Chemical amplification for the synthesis of patterned arrays 发明人:BEECHER JODY E; GOLDBERG MARTIN J; MCGALL GLENN H 权利人:AFFYMETRIX INC 摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.
专利号:US-2004110133-A1 优先权日:2002-12-06 标 题 :Functionated photoacid generator for biological microarray synthesis 发明人:XU GUANGYU; GOLDBERG MARTIN 权利人:AFFYMETRIX INC 摘要:In some embodiment of the invention, methods are provided for the synthesis of polymer arrays. In one embodiment, a chemically amplified polymer matrix is used for the synthesis of polymer arrays.
专利号:US-7053198-B2 优先权日:2002-12-06 标题 :Functionated photoacid generator and functionated polymer system for biological microarray synthesis 发明人:GOLDBERG MARTIN; XU GUANGYU 权利人:AFFYMETRIX INC 摘要:In some embodiment of the invention, methods are provided for the synthesis of polymer arrays. In one embodiment, a reactive polymer and a photo acid generator is used for the photodirected polymer array synthesis.
专利号:US-4559213-A 优先权日:1983-04-29 标 题 :Synthesis of ZSM-12 zeolite 发明人:KUEHL GUENTER H 权利人:MOBIL OIL CORP 摘要:There is disclosed a process for preparing a ZSM-12 crystalline zeolite wherein the organic template used in the synthesis has the formula: ##STR1## wherein n=4-10. The template, designated herein DABCO-C n -diquat, is obtained from a dihalide salt of the template or from a hydroxide thereof.
专利号:US-4482531-A 优先权日:1983-04-29 标题:Synthesis of ZSM-12 zeolite 发明人:KUEHL GUENTER H 权利人:MOBIL OIL CORP 摘要:There is disclosed a process for preparing a ZSM-12 crystalline zeolite wherein the organic template used in the synthesis has the formula: ##STR1## wherein n=4,5,6 or 10. The template, designated herein DABCO-C n -diquat, is obtained from a dihalide salt of the template or from a hydroxide thereof.
专利号:US-4143050-A 优先权日:1977-01-05 标题 :Manufacture of 3-halosulfonylthiophene-carboxylic acid compounds 发明人:ROSSY PHILLIP A; HOFFMANN WERNER; MUELLER NORBERT 权利人:BASF AG 摘要:3-Halosulfonylthiophene-carboxylic acid compounds are manufactured by reacting 3-ketothiophane-carboxylic acid compounds with sulfonic acid compounds, reacting the end product from the 1st reaction stage with alkali metal polysulfides, reacting the end product from the 2nd stage with a dehydrogenating agent and finally reacting the end product from the 3rd stage with halogen and water. The products are starting compounds for the manufacture of drugs, dyes and crop protection agents and have an anti-inflammatory, analgesic and anti-rheumatic action. In particular, the end products I are starting materials for the manufacture of sweeteners which are non-toxic and free from an after-taste, flavor-improving agents, diabetic aids and feedstuffs, and provide the means of a simple and economical synthesis of thiophene-saccharins.
[参考文献]: Elbieta Luboch, Et Al. Synthesis Of Thiol Derivatives Of Azobenzocrown Ethers. The Preliminary Studies On Recognition Of Alkali Metal Ions By Gold Nanoparticles Functionalized With Azobenzocrown And Lipoic Acid. J Incl Phenom Macrocycl Chem. 2015;83(3-4):321-334.
合成参考文献
摘要:Shinmyozu, T.; Shibahara, M., Science of Synthesis, (2010) 45, 1302. 摘要:Shinmyozu, T.; Shibahara, M., Science of Synthesis, (2010) 45, 1272. 摘要:Shinmyozu, T.; Shibahara, M., Science of Synthesis, (2010) 45, 1282. 摘要:Margaretha, P., Science of Synthesis Knowledge Updates, (2014) 2, 453.