CAS: 4506-71-2; Ethyl 2-Amino-4,5,6,7-Tetrahydrobenzo[b]Thiophene-3-Carboxylate

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CAS号108-94-1 环己酮 | CAS号105-56-6 氰乙酸乙酯 | CAS号6802-76-2 Acetic acid,2-c... | CAS号670-80-4 1-吗啉基-1-环己烯 | CAS号109164-47-8 3-(4-氧代-3,4,5,6... | CAS号40493-18-3 4-氯-5,6,7,8-四氢-... | CAS号60442-41-3 2-[(氯乙酰基)氨基]-4,... | CAS号14559-12-7 4,5,6,7-四氢苯并[b]... | CAS号143361-89-1 3-(1H-苯并咪唑-2-基)... | CAS号40277-39-2 5,6,7,8-四氢苯并[4,... | CAS号20886-87-7 2-(2-氯乙酰基氨基)-4,... | CAS号85716-87-6 2-异硫氰基-4,5,6,7-... | CAS号81765-97-1 4-氯-2-甲基-5,6,7,... | CAS号5919-29-9 乙基 2-(乙酰基氨基)-4,...

氰基环己亚基乙酸乙酯置于1,2,3,4,5,6,7,8-八硫杂环辛烷,L-脯氨酸体系中,用 二甲基亚砜 作为反应溶剂,以63%的收率获得产物2-氨基-4,5,6,7-四氢苯并噻酚-3-羧酸乙酯
参考文献:L-脯氨酸催化三组分gewald反应高效一锅法合成取代的2-氨基噻吩
标题:L-脯氨酸催化三组分gewald反应高效一锅法合成取代的2-氨基噻吩
摘要:已开发出一种在温和反应条件下由 L-脯氨酸催化直接催化合成取代 2-氨基噻吩的有效一锅法.通过该催化方案以高产率组装了多种功能化的2-氨基噻吩支架.低催化剂负载,简单程序和高产率是该方法的重要属性.
DOI:10.1055/s-0029-1219917

专利信息

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-9061984-B2
优先权日:2008-08-15
标题 :Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases
发明人：HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM
权利人:HAMMOND GERALD B; APONTE JOSE C; GILMAN ROBERT H; SAUVAIN MICHEL HENRI AUGUSTE; VAISBERG ABRAHAM; UNIV LOUISVILLE RES FOUND; UNIV PERUMA CAYETANO HEREDIA; INST RECH POUR LE DÉVELOPPEMENT; UNIV JOHNS HOPKINS
摘要:Embodiments of the present invention provide compounds (such as Formula (I) compounds, Formula (II) compounds, and various embodiments thereof). Compositions comprising those compounds are also provided. Methods for their preparation are included. Also, uses of the compounds are included, such as administering and treating diseases (e.g., cancer and infections).