CAS: 66-97-7; 7H-Furo[3,2-G]Chromen-7-One

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2009-24-7 484-20-8 298-81-7

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CAS号849144-95-2 xanthoarnol | CAS号6544-89-4 3,4-dihydropsoralen | CAS号7535-48-0 4',5'-dihydrops... | CAS号16851-02-8 2-(2-ox°Chromen... | CAS号52656-95-8 7-oxo-2,3-dihyd... | CAS号15085-71-9 小芸木素 | CAS号287171-02-2 (+)-(2'S,3'R)-3... | CAS号13196-11-7 6-苯并呋喃酚 | CAS号623-47-2 丙炔酸乙酯 | CAS号20073-22-7 5-Benzofurancar... | CAS号6544-89-4 3,4-dihydropsoralen | CAS号7535-48-0 4',5'-dihydrops... | CAS号19881-52-8 tetrahydropsoralen

(2'S,3'R)-3'-Hydroxymarmesin置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 1.33H,以100%的收率获得产物补骨脂素
参考文献:Synthesis Of 2,3-Dihydro-3-Hydroxy-2-Hydroxylalkylbenzofurans From Epoxy Aldehydes. One-Step Syntheses Of Brosimacutin G,Vaginidiol,Vaginol,Smyrindiol,Xanthoarnol,And Avicenol A. Biomimetic Syntheses Of Angelicin And Psoralen
标题:Synthesis Of 2,3-Dihydro-3-Hydroxy-2-Hydroxylalkylbenzofurans From Epoxy Aldehydes. One-Step Syntheses Of Brosimacutin G,Vaginidiol,Vaginol,Smyrindiol,Xanthoarnol,And Avicenol A. Biomimetic Syntheses Of Angelicin And Psoralen
摘要:[graphics]We Have Developed Two Practical One-Step Syntheses Of 2,3-Dihydro-3-Hydroxy-2-Hydroxyalkylbenzofurans From Readily Available Optically Pure Alpha,Beta-Epoxy Aldehydes. Electron-Deficient Resorcinols React With Epoxy Aldehydes Using Either Cs2Co3 In Dmf Or Koh/cacl2 In Meoh To Give Adducts 13,16,18,20,21,And Brosimacutin G (6T). Grignard Reagents Prepared By Low-Temperature Halogen-Metal Exchange Of Acetoxy Iodocoumarins 35D And 40 And Acetoxy Bromonaphthalene 41 Add To Epoxy Aldehyde (S)-26 To Complete The First Syntheses Of Vaginidiol (7C),Vaginol (7T),Smyrindiol (8C),Xanthoarnol (8T),And Avicenol A (9T). Acid-Catalyzed Fragmentation Of Vaginidiol Or Vaginol Provides Angelicin,While That Of Smyrindiol Or Xanthoarnol Affords Psoralen. In Both Cases,The Trans Isomers Fragment Only Twice As Fast As The Cis Isomers,Possibly Through The Intermediacy Of A Common Benzylic Cation. This May Have Implications For The Biosynthesis Of Angelicin And Psoralen.
DOI:10.1021/jo047974K

专利信息

专利号:US-5139940-A
优先权日:1989-10-26
标题 :Activation compounds and methods of synthesis of activation compounds
发明人：ISAACS STEPHEN T; CIMINO GEORGE D; METCHETTE KENNETH C; TESSMAN JOHN W
权利人:ISAACS STEPHEN T; CIMINO GOERGE D; METCHETTE KENNETH C; TESSMAN JOHN W
摘要:The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.

专利号:WO-2024153642-A1
优先权日:2023-01-16
标题 :Scarless template-free enzymatic synthesis of polynucleotides
发明人：HORGAN ADRIAN; VERARDO DAMIANO; ADELIZZI BEATRICE; RODRIGUEZ-PINZON DANIEL; THOMEE EMMA
权利人:DNA SCRIPT
摘要:Methods are provided for template-free enzymatic synthesis of polynucleotides on a solid support using double cleavage to produce scarless polynucleotides. In particular, methods are disclosed that use an initiator that comprises a cleavable group, which can be cleaved by a small molecule chemical agent, adjusting pH, heat, or photocleaved by illumination with light to release polynucleotides from a solid support after enzymatic synthesis is completed, and an enzymatic cleavage site, which can be cleaved by a cleavage enzyme to remove polynucleotide scars.

专利号:US-12146136-B2
优先权日:2020-03-26
标题:Synthesis of modified oligonucleotides with increased stability
发明人：KHVOROVA ANASTASIA; ROUX LOÃ?C MAURICE RENÉ JEAN; YAMADA KEN
权利人:UNIV MASSACHUSETTS
摘要:This disclosure relates to the synthesis of novel modified oligonucleotides. The synthesis of novel phosphoramidites are also provided.

专利号:US-7183095-B2
优先权日:2001-03-09
标题:Cell culture system for synthesis of infectious hepatitis C virus
发明人：DASGUPTA ASIM; KOKA PRASAD S
权利人:UNIV CALIFORNIA
摘要:The invention rates to a hepatitis C virus (HCV) cDNA-based culture system capable of synthesis of infectious HCV in cell culture and cell-to-cell spread of the virus. The invention also relates to a method of measuring the level of HCV infection in a hepatocyte cell. A method for identifying a modulator of HCV activity is also presented, and a method for modulating HCV activity. The invention provides a reliable system for both genetic analysis of the viral genome and for the development of novel antiviral strategies.

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:US-9440940-B2
优先权日:2014-03-18
标 题:Methods for synthesis of psoralen derivatives
发明人：REFOUVELET BERNARD
权利人:MACOPHARMA S A S
摘要:Methods for the synthesis of psoralen derivatives are provided. In one embodiment, the method may include acetylating a compound of formula (II) to form a compound of formula (III), subjecting the compound of formula (III) to a Fries rearrangement to form a compound of formula (IV), and subjecting the compound of formula (IV) to cyclization, reduction and aromatization, to form a compound having the following formula (I):