CAS: 762-49-2; 1-Bromo-2-Fluoroethane

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CAS号540-51-2 2-溴乙醇 | CAS号19263-21-9 2-溴乙基4-甲基苯磺酸盐 | CAS号54509-73-8 ethene | CAS号371-62-0 2-氟乙醇 | CAS号106-93-4 1,2-二溴乙烷 | CAS号103935-47-3 三氟甲磺酸(2-溴乙基)酯 | CAS号4239-10-5 Bromoethyl meth... | CAS号34714-03-9 (2-Bromoethoxy)... | CAS号107-21-1 乙二醇 | CAS号7789-60-8 三溴化磷 | CAS号461-56-3 3-氟丙酸 | CAS号184042-58-8 1-(2'-FLUORO)ET... | CAS号358-58-7 (2-fluoro-ethyl... | CAS号995-32-4 亚乙基二磷酸四乙酯 | CAS号762-51-6 1-氟-2-碘乙烷 | CAS号624-72-6 1,2-二氟乙烷 | CAS号155798-01-9 8-AZABICYCLO[3.... | CAS号318-87-6 N-ethyl-2-fluor... | CAS号318-88-7 2-fluoro-N-meth... | CAS号332-23-0 1-(2-fluoroethy...

2-氟乙醇置于三溴化磷体系中,化学反应生成 1-溴-2-氟乙烷
参考文献:构象稳定性,远红外光谱,内旋障碍,振动分配和 Rhf/sto-1-溴-2-氟乙烷的 3G* 计算
标题:构象稳定性,远红外光谱,内旋障碍,振动分配和 Rhf/sto-1-溴-2-氟乙烷的 3G* 计算
摘要:摘要 气态 1-溴-2-氟乙烷 Brch 2 Ch 2 F 的远红外光谱 (350-35 Cm-1) 的记录分辨率为 0.10 Cm-1.分别在 125.3 Cm-1 和 111.3 Cm-1 处观测到了稳定的反式(两个卤原子定向为反式)和高能伽马构象异构体,并且已经确定了控制 Cc 键内部旋转的不对称扭转势函数.该势函数给出了 V 1 =584+/-6,V 2 =-147+/-4,V 3 =1217+/-11,V 4 =138+/-2 和 V 4 =-21+4 Cm-的扭转势系数值1,以及 Gauche 构象异构体的二面角 (∠fccbr) 为 67°0.trans To Gauche,Gauche To Gauche 和 Gauche To Trans 障碍分别被确定为 1356 Cm-1,1418 Cm-1 和 973 Cm-1,构象之间的能量差为 383+/-21 Cm
DOI:10.1016/0022-2860(91)85002-K

专利信息

专利号:US-2007293706-A1
优先权日:2004-11-01
标 题:Synthesis Of 1,5-Disubstituted-2-Hydroxy-Gibbatetraen-6-Ones
发明人：WILKENING ROBERT R; FRIED AMY; PARKER DANN L JR
权利人:WILKENING ROBERT R; FRIED AMY; PARKER DANN L JR
摘要:1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones are useful as estrogen receptor modulators and as precursors to estrogen receptor modulators. The current invention provides a method for the synthesis of 1,5-disubstituted-2-hydroxy-gibbatetraen-6-ones from simple indanone starting materials via a Robinson-type annulation followed by an internal alkylation reaction. This invention further describes the novel use of a fluoroethyl substituent as a latent alkylating group for an internal cyclization reaction.

专利号:WO-9516653-A1
优先权日:1993-12-17
标 题 :Process for the synthesis of 1-bromo-2-fluoroethane
发明人：IIKUBO YUICHI; ZUBERI SHARIQUE S; BRANDSTADTER STEPHAN M; HEDRICK VICTORIA E; BORDEN DENNIS M
权利人:GREAT LAKES CHEMICAL CORP
摘要:A process for the bulk synthesis of 1-bromo-2-fluoroethane by reacting HBr and vinyl fluoride in the presence of an O2 catalyst in the liquid phase. More particularly, vinyl fluoride, hydrogen bromide and an O2 catalyst are dissovled in methylene chloride and mixed to form 1-bromo-2-fluoroethane.

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

专利号:US-6455680-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
发明人：LUKIN KIRILL A
权利人:ABBOTT LAB
摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

专利号:US-8193360-B2
优先权日:2003-07-31
标 题:Radiolabelled fluorobenzamide analogues, their synthesis and use in diagnostic imaging
发明人：MACH ROBERT H; TU ZHUDE
权利人:MACH ROBERT H; TU ZHUDE; UNIV WASHINGTON
摘要:Fluoroalkoxybenzamide compounds which selectively bind Sigma-2 receptors are disclosed. These compounds, when labelled with 18 F, can be used as radiotracers for imaging of tumors by positron emission tomography (PET). In addition, these compounds, when labelled with 123 I, can be used as radiotracers for imaging of tumors by single photon emission computed tomography (SPECT). Methods for synthesis of these compounds are also disclosed.

专利号:US-9428482-B2
优先权日:2011-01-27
标 题 :Process for synthesis of polyphenols
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE; SPHAERA PHARMA PTE LTD
摘要:The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.