CAS: 130336-16-2; 1-(3,5-Dichlorophenyl)-2,2,2-Trifluoroethanone

相似化合物

1187989-89-4 321-31-3 158401-00-4

上下游产品

1-bromo-3,5-dichlorobenzene trifluoroacetic anhydride 1-(3,5-dichlorophenyl)-2,2,2-trifluoro-1-trimethylsilyloxy-1-methoxyethane N-methoxy-N-methyltrifluoroacetamide 1-(3-chloro-4-methoxy-phenyl)-1-(3,5-dichloro-phenyl)-2,2,2-trifluoro-ethanol 1-(3-chloro-4-methylsulfanyl-phenyl)-1-(3,5-dichloro-phenyl)-2,2,2-trifluoro-ethanol 1-(3,5-dichloro-phenyl)-2,2,2-trifluoro-1-(4-methoxy-phenyl)-ethanol 1-[1-Bromo-2,2,2-trifluoro-1-(4-methoxy-phenyl)-ethyl]-3,5-dichloro-benzene

在 盐酸,水体系中,用85.3%的收率获得3',5'-二氯-2,2,2-三氟苯乙酮
参考文献:一种三氟苯乙酮衍生物的制备方法
标题:一种三氟苯乙酮衍生物的制备方法
摘要:本申请涉及有机合成领域,更具体地说,它涉及一种三氟苯乙酮衍生物的制备方法,以取代苯胺为原料,经重氮化反应,偶联反应和水解反应三步,完成三氟苯乙酮衍生物的制备.该制备方法工艺简单,收率较高,反应整体产生的三废较少,适用于工业大规模生产.

专利信息

专利号:US-2014371464-A1
优先权日:2012-02-03
标 题:Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents
发明人：BILLEN DENIS; GREENWOOD SEAN DAVID WILLIAM; STUK TIMOTHY LEE
权利人:ZOETIS LLC
摘要:The invention recites a chiral process for the synthesis of isoxazoline azetidine phenyl substituted derivatives of Formula (1) stereoisomers thereof, veterinarily acceptable salts thereof, processes for making, and their use as a parasiticide in an animal. The variables *, R 1a , R 1b , R 1c , R 2 , and R 3 are as described herein

专利号:WO-2024175691-A1
优先权日:2023-02-24
标题 :Process for the preparation of substituted chalcones
发明人：BOBNAR JERNEJ
权利人:KRKA D D NOVO MESTO
摘要:The invention relates to an improved process for the preparation of substituted chalcones using a base that plays double role in the process, as it removes free water and catalyzes aldol condensation. Consequently, the process is cost efficient and is easily scalable to industrial level. The substituted chalcones are useful intermediates in the synthesis of isoxazolines such as Fluralaner, Afoxolaner and Sarolaner, which are known systemic insecticides and acaricides.

专利号:WO-2022061917-A1
优先权日:2020-09-28
标题:Synthesis method for 3',5'-dichloro-2,2,2-trifluoroacetophenone
发明人：ZHANG LINGXIAO; CAI GANGHUA; TANG HONGYUAN; CHENG JINTAO
权利人:TAIZHOU ABSOBIOTEC CO LTD; ZHEJIANG JIANGBEI NANHAI PHARMACEUTICAL CO LTD
摘要:The present application relates to the technical field of chemical pharmaceutics, and in particular, to a synthesis method for 3',5'-dichloro-2,2,2-trifluoroacetophenone. The method comprises: first reacting 1,3,5-trichlorobenzene or 3,5-dichloro-1-bromobenzene with magnesium to form a Grignard reagent; and then subjecting the Grignard reagent and a trifluoroacetyl reagent to a nucleophilic addition reaction to obtain 3',5'-dichloro-2,2,2-trifluoroacetophenone after acid treatment. The synthesis method has mild reaction conditions, low raw material cost, favorable economic effect, and broad prospects for industrial production.

专利号:US-8853410-B2
优先权日:2009-04-30
标 题:Process for preparing substituted isoxazoline compounds and their precursors
发明人：RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN
权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE
摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.

专利号:JP-WO2009063910-A1
优先权日:2007-11-12
标 题 :Catalytic asymmetric synthesis of optically active isoxazoline compounds

专利号:CN-113512007-A
优先权日:2021-08-20
标题 :Synthesis of Florana